Unsaturated fatty acids inhibit sterol regulatory element-dependent gene expression: A potential mechanism contributing to hypertriglyceridemia in fat-restricted diets

Proceedings of the Society for Experimental Biology and Medicine

Volumn 225, Issue 3, 2000, Pages 184-186

  Deckelbaum, Richard J ^a   Johnson, Rebecca A ^a   Worgall, Tilla S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CHOLESTEROL; FATTY ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; UNSATURATED FATTY ACID;

CARBOHYDRATE METABOLISM; CHOLESTEROL METABOLISM; CONFERENCE PAPER; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; GENE FUNCTION; HYPERTRIGLYCERIDEMIA; LIPID METABOLISM; LOW FAT DIET; PROMOTER REGION; REGULATOR GENE;

CCAAT-ENHANCER-BINDING PROTEINS; DIET, FAT-RESTRICTED; DNA-BINDING PROTEINS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION; HUMANS; HYPERTRIGLYCERIDEMIA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 0034518814     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22522.x     Document Type: Conference Paper

References (15)

1. Dietary fatty acids regulate hepatic low-density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels
2. 42-bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter
3. Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
4. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
5. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein- 2
6. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
7. A crucial role of sterol regulatory element-binding protein- 1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
8. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids: A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
9. Free fatty acids enhance cholesterol movement between model membranes
10. Polyunsaturated fatty acids decrease sterol regulatory element-dependent gene transcription by three interdependent processes
11. Sterol-independent, sterol response element-dependent regulation of low-density lipoprotein receptor gene expression
12. Multiple mechanisms, independent of sterol regulatory element binding proteins, regulate low-density lipoprotein gene transcription
13. Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
14. Human fatty acid synthesis is stimulated by a eucaloric low-fat, high-carbohydrate diet
15. Primary prevention of coronary heart disease in women through diet and lifestyle