Stability and peptide binding specificity of Btk SH2 domain: Molecular basis for X-linked agammaglobulinemia

Protein Science

Volumn 9, Issue 12, 2000, Pages 2377-2385

  Tzeng, Shiou Ru ^a   Pai, Ming Tao ^a   Lung, Feng Di T ^b   Wu, Chih Wei ^a   Roller, Peter P ^c   Lei, Benfang ^d,g   Wei, Chih Jen ^d   Tu, Shiao Chun ^d   Chen, Shi Han ^e   Soong, Wen Jue ^f   Cheng, Jya Wei ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d University of Houston   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Btk; CD; Phosphopeptide binding; SH2 domain; SPR; XLA

Indexed keywords

PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BACTERIAL INFECTION; BINDING AFFINITY; CELL MATURATION; CIRCULAR DICHROISM; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; X LINKED AGAMMAGLOBULINEMIA;

BACTERIA (MICROORGANISMS);

EID: 0034495158     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.12.2377     Document Type: Article

References (59)

1. Structure of the PH domain from Bruton's tyrosine kinases in complex with inositol 1,3,4,5-tetrakiphosphate
2. Mutation detection in the X-linked agammaglobulinemia gene. BTK, using single strand conformation polymorphism analysis
3. Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: A thermodynamic study
4. Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase
5. Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: Dissection of the phosphopeptide sequence specificity and coupling energetics
6. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
7. Stability and folding of the SH3 domain of Bruton's tyrosine kinase
8. Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction
9. Solution conformation of a peptide corresponding to residues 151-172 of HIV-1 integrase using NMR and CD spectroscopy
10. Modular binding domains in signal transduction proteins
11. Mutations in BTK patients with presumed X-linked agammaglobulinemia
12. The protein product of the c-cb1 protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase
13. Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: Identification of a mutation which affects the same codon as is altered in immunodeficient xid mice
14. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation
15. Characterization and binding specificity of the monomerie STAT3-SH2 domain
16. Genomic organization of the Btk gene and exon scanning for mutations in the patients with X-linked agammaglobulinemia
17. Molecular basis for human immunodeficiencies
18. Solution structure of the SH3 domain from Bruton's tyrosine kinase
19. Identification of the SH2 domain binding protein of Braton's tyrosine kinase as BLNK-functional significance of Btk SH2 domain in B-cell antigen receptor-coupled calcium signaling
20. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agammaglobulinaemia
21. Physiological requirement for both SH2 domains for phospholipase C-gammal function and interaction with platelet derived growth factor receptors
22. Fusion PCR, a one-step variant of the megaprimer method of mutagenesis
23. Structures of SH2 and SH3 domains
24. Searching for specificity in SH domains
25. Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: A reappraisal
26. Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits
27. The SH3 domain Of Bruton's tyrosine kinase displays altered ligand binding properties When auto-phosphorylated in vitro
28. Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases
29. Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: Structural features and analysis of conformational changes
30. SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cb1
31. Protein modules and signalling networks
32. SH2 and SH3 domains
33. A point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia
34. Src homology-2 domains: Structure, mechanisms, and drug discovery
35. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
36. Detection of a novel mutation in the Src homology domain 2 (SH2) of Bruton's tyrosine kinase and direct female carrier evaluation in a family with X-linked agammaglobulinemia
37. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
38. Tyrosine kinases: Modular signaling enzymes with tunable specificities
39. Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells
40. X-linked agammaglobulinemia and other immunoglobulin deficiencies
41. Recognition and specificity in protein tyrosine kinase-mediated signaling
42. A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains
43. SH2 domains recognize specefic phosphopeptide sequences
44. Interaction of SLP adaptors with the SH2 domain of Tec family kinases
45. From Src Homology domains to other signaling modules: Proposal of the "protein recognition code"
46. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma2
47. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
48. Binding of βγ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase
49. Solution structure of the BTK SH3 domain complexed with a proline-rich peptide from p120cb1
50. The gene involved in X-linked agammaglobulinaemia is a member of the src family of proteintyrosine kinases
51. BTKbase, mutation database for X-linked agammaglobulinemia (XLA)
52. Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia
53. DNA-based mutation analysis of Bruton's tyrosine gene in patients with X-linked agammaglobulinemia
54. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
55. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms
56. Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding
57. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
58. Signaling an interest
59. Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA)