Chromosome structure and sequence organization between pathogenic and non-pathogenic Leishmania spp

Molecular and Biochemical Parasitology

Volumn 111, Issue 2, 2000, Pages 401-414

  Tamar, Samira ^a   Dumas, Carole ^a   Papadopoulou, Barbara ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Chromosome fragmentation; Chromosome structure; I SceI endonuclease; Leishmania spp; Sequence organization

Indexed keywords

ENDONUCLEASE; HYGROMYCIN; HYGROMYCIN PHOSPHOTRANSFERASE; KANAMYCIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHROMOSOME ANALYSIS; CHROMOSOME STRUCTURE; CONTROLLED STUDY; COSMID VECTOR; DNA HYBRIDIZATION; DNA SEQUENCE; GENE ACTIVITY; GENE LOCATION; GENE MAPPING; GENE TARGETING; GENETIC TRANSFECTION; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA TARENTOLAE; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANIMALS; CELLS, CULTURED; CHROMOSOMES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA FRAGMENTATION; ELECTROPHORESIS, GEL, PULSED-FIELD; GENETIC MARKERS; GENETIC TECHNIQUES; GENOME, PROTOZOAN; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; NUCLEIC ACID HYBRIDIZATION; OXIDOREDUCTASES; PHYSICAL CHROMOSOME MAPPING; SPECIES SPECIFICITY; TRANSFECTION;

LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA TARENTOLAE;

EID: 0034491951     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00337-6     Document Type: Article

References (75)

1. Molecular karyotype analysis in Leishmania
2. Assignment of genes to Leishmania infantum chromosomes: Karyotype and ploidy
3. The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species
4. The complete chromosomal organization of the reference strain of the Leishmania genome project, L. major 'Friedlin'
5. Conservation among Old World Leishmania species of six physical linkage groups defined in Leishmania infantum small chromosomes
6. Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes
7. High conservation of the fine-scale organisation of chromosome 5 between two pathogenic Leishmania species
8. Chromosome specific markers reveal conserved linkage groups in spite of extensive chromosomal size variation in Trypanosoma cruzi
9. The molecular karyotype of the megabase chromosomes of Trypanosoma brucei and the assignment of chromosome markers
10. Chromosome organization of the protozoan Trypanosoma brucei
11. Multiple causes of size variation in the diploid megabase chromosomes of African tyrpanosomes
12. Long-range restriction maps of size-variable homologous chromosomes in Leishmania infantum
13. Medium-range restriction maps of five chromosomes of Leishmania infantum and localization of size-variable regions
14. The size difference between Leishmania major friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end
15. Transcriptional differences in polymorphic and conserved domains of a complete cloned P. falciparum chromosome
16. Parasitism and chromosome dynamics in protozoan parasites: Is there a connection?
17. A polymorphic minisatellite sequence in the subtelomeric regions of chromosomes I and V in Leishmania infantum
18. Analysis of the genomic organization of a small chromosome of Leishmania braziliensis M2903 reveals two genes encoding GTP-binding proteins, one of which belongs to a new G-protein family and is an antigen
19. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes
20. A physical map of the Leishmania major Friedlin genome
21. Recognition and cleavage site of the intron-encoded omega transposase
22. Purification and characterization of the in vitro activity of I-Sce I, a novel and highly specific endonuclease encoded by a group I intron
23. Asymmetrical recognition and activity of the I-SceI endonuclease on its site and on intron-exon junctions
24. Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: A new method for physical mapping of eukaryotic genomes
25. Construction of a complete genomic library of Saccharomyces cerevisiae and physical mapping of chromosome XI at 3.7 kb resolution
26. Rapid physical mapping of YAC inserts by random integration of I-Sce I sites
27. Physical distance between the site of type II DNA binding to the membrane and oriC on the Bacillus subtilis 168 chromosome
28. Study of the organization of the genomes of Escherichia coli, Brucella melitensis and Agrobacterium tumefaciens by insertion of a unique restriction site
29. Genomic fluidity of Bordetella pertussis assessed by a new method for chromosomal mapping
30. Genome structure and phylogeny in the genus Brucella
31. Genomic organization of the yeast Yarrowia lipolytica
32. Integrated physical and genetic mapping of Bacillus cereus and other gram-positive bacteria based on IS231A transposition vectors
33. Type-specific contributions to chromosome size differences in Escherichia coli
34. The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance
35. Developmental regulation of spliced leader RNA gene in Leishmania donovani amastigotes is mediated by specific polyadenylation
36. A novel antifolate resistance gene on the amplified H circle of Leishmania
37. Autonomous replication of bacterial DNA plasmid oligomers in Leishmania
38. Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani
39. Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania
40. Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end
41. Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania
42. Structure of the growing telomeres of Trypanosomes
43. Shuttle cosmid vectors for the trypanosomatid parasite Leishmania
44. Identification of genes by functional complementation in protozoan parasite Leishmania
45. Genetic manipulation of kinetoplastida
46. Trans-splicing of nuclear pre-mRNAs
47. Coupling of poly(A) site selection and trans-splicing in Leishmania
48. Cleavage of yeast and bacteriophage T7 genomes at a single site using the rare cutter endonuclease I-SceI
49. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
50. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus
51. Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene
52. PTR1: A reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
53. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene
54. Parameters controlling the rate of gene targeting frequency in the protozoan parasite Leishmania
55. Conservation of genetic linkage between heat shock protein 100 and glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei and Trypanosoma cruzi
56. Conserved organization of genes in trypanosomatids
57. Gene synteny in species of Plasmodium
58. Evolution of the genus Leishmania as revealed by comparisons of nuclear DNA restriction fragment patterns
59. Leishmania tarentolae taxonomic relatedness inferred from phylogenetic analysis of the small subunit ribosomal RNA gene
60. Phylogenetic relationships between Leishmania, Viannia and Sauro Leishmania inferred from comparison of a variable domain within the RNA polymerase II largest subunit gene
61. Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae
62. Is sex better? Parasites say 'no'
63. Identification of intra- and interspecific Leishmania genetic polymorphisms by arbitrary primed polymerase chain reactions and use of polymorphic DNA to identify differentially regulated genes
64. Conservation of low-copy gene loci in Old World Leishmanias identifies mechanisms of parasite evolution and diagnostic markers
65. Molecular karyotype of five species of Leishmania and analysis of gene locations and chromosomal rearrangements
66. Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex
67. Leishmania: Immunochemical comparison of the secretory (extracellular) acid phosphatases from various species
68. Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral Leishmaniasis
69. Developmental gene expression in Leishmania donovani: Differential cloning and analysis of an amastigote-stage-specific gene
70. Genomic DNA repeat from Leishmania (Viannia) braziliensis (Venezuelan strain) containing simple repeats and microsatellites
71. Generation of species-specific DNA probes for Leishmania aethiopica
72. Leishmania virulence and genetic heterogeneity
73. Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major