Metallothionein expression prevents apoptosis. II: Evaluation of the role of metallothionein expression on the chemotherapy-induced apoptosis during the treatment of acute leukemia

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4407-4412

  Tsangaris, G Th ^a   Vamvoukakis, J ^a   Politis, I ^a   Kattamis, A C ^a   Tzortzatou Stathopoulou, F ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Acute leukemia; Apoptosis; Chemotherapy; Metallothionein; Peripheral blood; Resistance

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYSTEINE; METALLOTHIONEIN; METHOTREXATE; PROTEIN; VINCRISTINE;

ACUTE LEUKEMIA; APOPTOSIS; ARTICLE; BLAST CELL; BLOOD SAMPLING; BLOOD SMEAR; BONE MARROW; CANCER CHEMOTHERAPY; CENTRIFUGATION; CHILD; CLINICAL ARTICLE; EUKARYOTE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ACUTE DISEASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE MARROW; CHILD; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA; METALLOTHIONEIN; NEOPLASM PROTEINS; TIME FACTORS;

EID: 0034479840     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Regulation of human and yeast metallothionein gene trancription by heavy metal ions
2. Functional analysis of the human metallothionein-1G gene
3. Activation of metallothionein gene expression by hypoxia involves metal responce elements and metal transcription factor-1
4. 2+ in a human T cell line
5. Metallothioneins and cell death by anticancer drugs
6. Metallothionein expression prevents apoptosis: A study with antisense phosphorothioate oligodeoxynucleotides in a human T cell line
7. Study of apoptosis in peripheral blood of patients with acute lymphoblastic leukemia during induction therapy
8. Gene regulation of chemotherapy-induced apoptosis in the treatment of acute leukemia
9. Development of a quantitative plethod for the study of apoptosis in peripheral blood
10. A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs
11. Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis
12. Mechanisms of resistance to alkylating agents
13. Metallothionein content correlates with the sensitivity of human small cell lung cancer cells lines to cisplatin
14. Multidrug resistance and its reversal
15. Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells
16. Expression of metallothionein in initial and relapsed childhood acute lymphoblastic leukemia
17. Metallothionein in human disease