Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4279-4284

  Uefuji, K ^a   Ichikura, T ^a   Shinomiya, N ^a   Mochizuki, H ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Apoptosis; Bcl 2; C myc; Cell cycle; Cyclooxygenase 2; Gastric cancer

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DNA FRAGMENT; MESSENGER RNA; MYC PROTEIN; PROSTAGLANDIN E2; PROTEIN BCL 2; TILMACOXIB;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BENZENESULFONATES; CELL DIVISION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; NEOPLASM PROTEINS; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; S PHASE; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0034477132     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Prostaglandin endoperoxide synthase: Regulation of enzyme expression
2. Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells
3. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
4. Towards a better aspirin
5. Expression of prostaglandin G/H synthase-1 and -2 protein inhumancolon cancer
6. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: Evidence for a transcriptional effect
7. Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas
8. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
9. Increased expression of cyclooxygenase-2 occurs frequently in human lung cancers, Specifically in adenocarcinomas
10. Cyclooxygenase-2 expression in human esophageal carcinoma
11. Expression of cyclooxygenase-2 protein in gastric adenocarcinoma
12. Expression of cyclooxygenase-2 in human gastric carcinoma
13. Altered eicosanoid levels in human colon cancer
14. Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer
15. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
16. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2
17. Modulation ofapoptosis and Bcl- 2 expression byprostaglandin E2 in human colon cancer cells
18. Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines
19. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
20. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
21. δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
22. Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats
23. Inhibitory effects of JTE-522, a novel prostaglandin H synthase-2 inhibitor, on adjuvant-induced arthritis and bone changes in rats
24. Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes
25. Different cell cycle mechanisms between UV-induced and X-ray-induced apoptosis in WiDr colorectal carcinoma cells
26. Aspirinuseandreduced risk of fatal colon cancer
27. Differential growth inhibition by aspirin metabolite salicylate in human colorectal tumor cell lines: Enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma cell lines
28. Nonsteroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis
29. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc
30. Yes, but do they still get headaches?
31. Biologic effects of nonsteroidal anti-inflammatory drugs
32. Profile of JTE-522 as a human cyclooxygenase-2 inhibitor
33. Increased cyclooxygenase-2 expression in human pancreatic carcinoma and cell lines: Growth inhibition by Nonsteroidal anti-inflammatory drugs
34. Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells
35. Induction of apoptosis in fibroblasts by c-myc protein
36. G1 events and regulation of cell proliferation
37. Bcl-2 initiates a new category of oncogenes: Regulators of cell death
38. Cyclooxygenase-2 overexpression enhanced lymphatic invasion and metastasis in human gastric carcinoma