Multifunctional role of proteases in rheumatic diseases

Advances in Experimental Medicine and Biology

Volumn 477, Issue , 2000, Pages 467-476

  Kekow, J ^a   Pap, T ^a   Zielinski, S ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEINASE;

BONE DESTRUCTION; CARTILAGE DEGENERATION; CONFERENCE PAPER; ENZYME REGULATION; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CATHEPSINS; CYTOKINES; ENDOPEPTIDASES; EXTRACELLULAR MATRIX PROTEINS; HUMANS; METALLOENDOPEPTIDASES; PROTEIN PRECURSORS; RHEUMATIC DISEASES; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 0034473092     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (47)

1. Nitric oxide synthase and cyclooxygenases: Distribution, regulation, and intervention in arthritis
2. In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium
3. Selective proteolytical cleavage of the ligand-binding chains of the IL-2-receptor and Il-6-receptor by neutrophil-derived proteases
4. The AP-1 site and MMP gene regulation: What is all the fuss about?
5. Collagen induced arthritis: Reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action
6. Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy
7. Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model
8. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1 beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
9. Inflammation and joint destruction during rheumatoid polyarthritis: What relation?
10. Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
11. Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis
12. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases
13. Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis
14. Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium
15. Regulation of neutrophil activation by proteolytic processing of platelet-derived alpha-chemocines
16. Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades
17. Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1
18. Cathepsin K mRNA expression in normal synovial cells and cells from patients with rheumatoid arthritis (RA) and osteoarthritis (OA)
19. Degradation of decorin by matrix metalloproteinases: Identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release
20. Egr family member proteins are involved in the activation of the cathepsin L gene in v-src-transformed cells
21. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146
22. Degradation of humoral host defense by Candida albicans proteinase
23. Inactivation of interleukin-8 by aminopeptidase N (CD13)
24. Interaction of transforming growth factor beta (TGF beta) with proteinase 3
25. Intravenous immunoglobulins and transforming growth factor beta
26. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme
27. The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression
28. Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells
29. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo
30. Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium
31. Transforming growth factor-beta and cellular immune responses in synovial fluids
32. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
33. Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction
34. Cysteine proteinases in arthritis and inflammation
35. Proteinases and matrix degradation
36. In-situ expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) and MT3-MMP mRNA in rheumatoid arthritis (RA)
37. Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes
38. IL4 and TGFβ regulate the expression of membrane peptidase CD10 on human fibroblast like synoviocytes
39. A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens
40. Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor
41. Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage
42. Determination of transforming growth factor beta 2 in human blood samples by ELISA
43. Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV
44. Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells
45. Increased serum proMMP-3 in inflammatory arthritides: A potential indicator of synovial inflammatory monokine activity
46. Expression of the collagenolytic and ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis