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Volumn 31, Issue 3, 1997, Pages 413-423

Pharmacokinetics of antisense analogues in the central nervous system

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ENDONUCLEASE; EXONUCLEASE; PHOSPHODIESTER; PHOSPHOROTHIOIC ACID; UNCLASSIFIED DRUG;

EID: 0030792460     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00111-8     Document Type: Article
Times cited : (18)

References (43)
  • 1
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice
    • Agrawal, S., Temsamani, J. and Tang, J. Y. (1991) Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. U.S.A. 88, 7595-7599.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 7595-7599
    • Agrawal, S.1    Temsamani, J.2    Tang, J.Y.3
  • 2
    • 0026550810 scopus 로고
    • Cellular uptake and intracellular fate of antisense oligonucleotides
    • Akhtar, S. and Juliano, R. L. (1992) Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell. Biol. 2, 139-144.
    • (1992) Trends Cell. Biol. , vol.2 , pp. 139-144
    • Akhtar, S.1    Juliano, R.L.2
  • 4
    • 0025346998 scopus 로고
    • Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid
    • Campbell, J, M., Bacon, T. A. and Wickstrom, E. (1990) Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid. J. Biochem. Biophys. Meth. 20, 259-267.
    • (1990) J. Biochem. Biophys. Meth. , vol.20 , pp. 259-267
    • Campbell, J.M.1    Bacon, T.A.2    Wickstrom, E.3
  • 6
    • 0003098462 scopus 로고
    • Medicinal chemistry strategies for antisense research
    • (Crooke S. T. and Lebleu B., Eds), CRC Press, Ann Arbor
    • Cook P. D. (1993) Medicinal chemistry strategies for antisense research. In Antisense Research and Applications (Crooke S. T. and Lebleu B., Eds), pp. 149-189. CRC Press, Ann Arbor.
    • (1993) Antisense Research and Applications , pp. 149-189
    • Cook, P.D.1
  • 7
    • 0026356572 scopus 로고
    • In vitro toxicology and pharmacokinetics of antisense oligonucleotides
    • Crook, R. M. (1991) In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anti-Cancer Drug Design 6, 609-646.
    • (1991) Anti-cancer Drug Design , vol.6 , pp. 609-646
    • Crook, R.M.1
  • 8
    • 0028609906 scopus 로고
    • c-fos antisense reduces expression of Krox 24 in rat caudate and neocortex
    • Dragunow, M., Tse, C., Glass, M. and Lawlor, P. (1994) c-fos antisense reduces expression of Krox 24 in rat caudate and neocortex. Cell. Mol. Neurobiol. 14, 395-405.
    • (1994) Cell. Mol. Neurobiol. , vol.14 , pp. 395-405
    • Dragunow, M.1    Tse, C.2    Glass, M.3    Lawlor, P.4
  • 9
    • 0021891882 scopus 로고
    • Nucleoside phosphorothioates
    • Eckstein, F. (1985) Nucleoside phosphorothioates. Annu. Rev. Biochem. 54, 367-402.
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 367-402
    • Eckstein, F.1
  • 10
    • 0028587325 scopus 로고
    • Use of phosphorothioated antisense oligonucleotides for sequence-dependent modulation of hematopoesis in culture
    • Ehrlich, G., Patinkin, D., Ginzberg, D., Zakut, H., Eckstein, F. and Soreq, H. (1994) Use of phosphorothioated antisense oligonucleotides for sequence-dependent modulation of hematopoesis in culture. Antisense Res. Devl. 4, 173-183.
    • (1994) Antisense Res. Devl. , vol.4 , pp. 173-183
    • Ehrlich, G.1    Patinkin, D.2    Ginzberg, D.3    Zakut, H.4    Eckstein, F.5    Soreq, H.6
  • 11
    • 0026573769 scopus 로고
    • Phosphorothioate oligonucleotides are inhibitors of human DNA polimerases and RNAse H: Implications for antisense technology
    • Gao, W. I., Han, F. S., Storm, C., Egan, W. and Cheng, Y. C. (1992) Phosphorothioate oligonucleotides are inhibitors of human DNA polimerases and RNAse H: implications for antisense technology. Mol. Pharmacol. 41, 223-229.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 223-229
    • Gao, W.I.1    Han, F.S.2    Storm, C.3    Egan, W.4    Cheng, Y.C.5
  • 12
    • 0027418989 scopus 로고
    • Phosphorothioate-phosphodiester oligonucleotide copolimers: Assessment for antisense application
    • Ghosh, M. K., Gllosh, K. and Cohen, J. S. (1993) Phosphorothioate-phosphodiester oligonucleotide copolimers: assessment for antisense application. Anti-Cancer Drug Design 8, 15-39.
    • (1993) Anti-cancer Drug Design , vol.8 , pp. 15-39
    • Ghosh, M.K.1    Gllosh, K.2    Cohen, J.S.3
  • 14
  • 15
    • 0016591230 scopus 로고
    • RNA polymerase activity in various classes of nuclei from different regions of rat brain during postnatal development
    • Giuffrida, A., Cox, D. and Mathias, A. P. (1975) RNA polymerase activity in various classes of nuclei from different regions of rat brain during postnatal development. J. Neurochem. 24, 749-755.
    • (1975) J. Neurochem. , vol.24 , pp. 749-755
    • Giuffrida, A.1    Cox, D.2    Mathias, A.P.3
  • 17
    • 0027310376 scopus 로고
    • c-Fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine
    • Heilig, M., Engel, J. A. and Soderpalm, B. (1993) c-Fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. Eur. J. Pharmacol. 236, 339-340.
    • (1993) Eur. J. Pharmacol. , vol.236 , pp. 339-340
    • Heilig, M.1    Engel, J.A.2    Soderpalm, B.3
  • 18
    • 0025339373 scopus 로고
    • Specific regulation of gene expression by antisense, sense and antigene nucleic acids
    • Hélène, C. and Toulmé, J. J. (1990) Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim. Biophys. Acta 1049, 99-125.
    • (1990) Biochim. Biophys. Acta , vol.1049 , pp. 99-125
    • Hélène, C.1    Toulmé, J.J.2
  • 19
    • 0026048056 scopus 로고
    • Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection
    • Hoke, G. D., Draper, K., Freier, S. M., Gonzalez, C., Driver, V. B., Zounes, M. C. and Ecker, D. J. (1991) Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection, Nucl. Acids Res. 19, 5743-5748.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 5743-5748
    • Hoke, G.D.1    Draper, K.2    Freier, S.M.3    Gonzalez, C.4    Driver, V.B.5    Zounes, M.C.6    Ecker, D.J.7
  • 20
    • 0027268608 scopus 로고
    • Cellular uptake of phosphorothioate oligodeoxynucleotides is negatively affected by cell density in a transformed rat tracheal epithelial cell line: Implication for antisense approaches
    • Iwanaga, T. and Ferriola, P. C. (1993) Cellular uptake of phosphorothioate oligodeoxynucleotides is negatively affected by cell density in a transformed rat tracheal epithelial cell line: implication for antisense approaches. Biochem. Biophys. Res. Commun. 191, 1152-1157.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 1152-1157
    • Iwanaga, T.1    Ferriola, P.C.2
  • 21
    • 0026522713 scopus 로고
    • Reversal of diabetes insipidus in Brattleboro rats: Intrahypothalamic injection of vasopressin mRNA
    • Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D. and Bloom, F. (1993) Reversal of diabetes insipidus in Brattleboro rats: intrahypothalamic injection of vasopressin mRNA. Science 255, 996-998.
    • (1993) Science , vol.255 , pp. 996-998
    • Jirikowski, G.F.1    Sanna, P.P.2    Maciejewski-Lenoir, D.3    Bloom, F.4
  • 22
    • 0022491546 scopus 로고
    • Extensive post-mortem stability of RNA from rat and human brain
    • Johnson, S. A., Morgan, D. G. and Finch, C. E. (1986) Extensive post-mortem stability of RNA from rat and human brain. J. Neurosci. Res. 16, 267-280.
    • (1986) J. Neurosci. Res. , vol.16 , pp. 267-280
    • Johnson, S.A.1    Morgan, D.G.2    Finch, C.E.3
  • 24
    • 0019887828 scopus 로고
    • Deoxyribonuclease I in mammalian tissues
    • Lacks, S. A. (1981) Deoxyribonuclease I in mammalian tissues. J. Biol. Chem. 256, 2644-2648.
    • (1981) J. Biol. Chem. , vol.256 , pp. 2644-2648
    • Lacks, S.A.1
  • 25
    • 0028170006 scopus 로고
    • Suppression of ischemia-induced c-fos expression and AP-1 activity by an antisense oligonucleotide to c-fos mRNA
    • Liu, P. K., Salminen, A., He, Y. Y., Jiang, M. H., Xue, J. J., Liu, J. S., Hsu, C. Y. and Hsu, C. Y. (1994) Suppression of ischemia-induced c-fos expression and AP-1 activity by an antisense oligonucleotide to c-fos mRNA. Ann. Neurol. 36, 566-576.
    • (1994) Ann. Neurol. , vol.36 , pp. 566-576
    • Liu, P.K.1    Salminen, A.2    He, Y.Y.3    Jiang, M.H.4    Xue, J.J.5    Liu, J.S.6    Hsu, C.Y.7    Hsu, C.Y.8
  • 27
    • 0001014648 scopus 로고
    • Cellular internalization of oligodeoxynucleotides
    • (Crooke S. T. and Lebleu B., Eds.), CRC Press, Ann Arbor
    • Neckers L. M. (1993) Cellular internalization of oligodeoxynucleotides. In Antisense Research and Applications (Crooke S. T. and Lebleu B., Eds.), pp. 452-459. CRC Press, Ann Arbor..
    • (1993) Antisense Research and Applications , pp. 452-459
    • Neckers, L.M.1
  • 28
    • 0028348647 scopus 로고
    • Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat
    • Ogawa, S., Olazabal, U. E., Parhar, I. S. and Pfaff, D. W. (1994) Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat. J. Neurosci. 14, 1766-1774.
    • (1994) J. Neurosci. , vol.14 , pp. 1766-1774
    • Ogawa, S.1    Olazabal, U.E.2    Parhar, I.S.3    Pfaff, D.W.4
  • 30
    • 0027213081 scopus 로고
    • Antisense oligonucleotide blocks progesterone-induced lordosis behaviour in ovarectomised rats
    • Pollio, G., Xue, P., Zanisi, M., Nicolin, A. and Maggi, A. (1993) Antisense oligonucleotide blocks progesterone-induced lordosis behaviour in ovarectomised rats. Mol. Brain. Res. 19, 135-139.
    • (1993) Mol. Brain. Res. , vol.19 , pp. 135-139
    • Pollio, G.1    Xue, P.2    Zanisi, M.3    Nicolin, A.4    Maggi, A.5
  • 31
    • 0029003784 scopus 로고
    • c-Fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum
    • Robertson, G. S., Tetzlaff, W., Bedard, A., St-Jean, M. and Wigle, N. (1995) c-Fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum. Neuroscience 67, 325-344.
    • (1995) Neuroscience , vol.67 , pp. 325-344
    • Robertson, G.S.1    Tetzlaff, W.2    Bedard, A.3    St-Jean, M.4    Wigle, N.5
  • 33
    • 0025738773 scopus 로고
    • Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution
    • Smidt, P. C., Doan, T., Falco, S. and Berkel, T. J. C. (1991) Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution. Nucl. Acids Res. 19, 4695-4700.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 4695-4700
    • Smidt, P.C.1    Doan, T.2    Falco, S.3    Berkel, T.J.C.4
  • 34
    • 0027724885 scopus 로고
    • Antisense oligonucleotide to c-fos induces ipsilateral rotational behavior to d-amphetamine
    • Sommer, W., Bjelke, B., Ganten, D. and Fuxe, K. (1993) Antisense oligonucleotide to c-fos induces ipsilateral rotational behavior to d-amphetamine. Neuroreport 5, 277-280.
    • (1993) Neuroreport , vol.5 , pp. 277-280
    • Sommer, W.1    Bjelke, B.2    Ganten, D.3    Fuxe, K.4
  • 35
    • 0028805465 scopus 로고
    • Antisense oligodeoxynucleotides to the cloned d receptor DOR-1: Uptake, stability, and regulation of gene expression
    • Standifer, K. M., Jenab, S., Su, W., Chien, C. C., Pan, Y. X., Inturrisi, C. E. and Pasternak, W. (1995) Antisense oligodeoxynucleotides to the cloned d receptor DOR-1: uptake, stability, and regulation of gene expression. J. Neurochem. 65, 1981-1987.
    • (1995) J. Neurochem. , vol.65 , pp. 1981-1987
    • Standifer, K.M.1    Jenab, S.2    Su, W.3    Chien, C.C.4    Pan, Y.X.5    Inturrisi, C.E.6    Pasternak, W.7
  • 36
    • 0021148470 scopus 로고
    • Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides
    • Stec, W. J., Zon, G., Egan, W. and Stec, B. (1984) Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides. J. Am. Chem. Soc. 106, 6077-6079.
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 6077-6079
    • Stec, W.J.1    Zon, G.2    Egan, W.3    Stec, B.4
  • 37
    • 0024296609 scopus 로고
    • Physicochemical properties of phosphorothioate oligodeoxynucleotides
    • Stein, C. A., Subasinghe, C., Shinozuka, K. and Cohen, J. S. (1988) Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucl. Acids Res. 16, 3209-3291.
    • (1988) Nucl. Acids Res. , vol.16 , pp. 3209-3291
    • Stein, C.A.1    Subasinghe, C.2    Shinozuka, K.3    Cohen, J.S.4
  • 39
    • 0029146043 scopus 로고
    • Antisense oligodeoxyribonucleotides: Stability and distribution after intracerebral infusion into rat brain
    • Szklarczyk, A. and Kaczmarek, L. (1995) Antisense oligodeoxyribonucleotides: stability and distribution after intracerebral infusion into rat brain. J. Neurosci. Meth. 60, 181-187.
    • (1995) J. Neurosci. Meth. , vol.60 , pp. 181-187
    • Szklarczyk, A.1    Kaczmarek, L.2
  • 40
  • 41
    • 0028180462 scopus 로고
    • Antisense oligonucleotide strategies in neuropharmacology
    • Wahlestedt, C. (1994) Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15, 42-46.
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 42-46
    • Wahlestedt, C.1
  • 42
    • 0027298897 scopus 로고
    • Stability, clearance and disposition of intraventriculary administered oligodeoxynucleotides: Implications for therapeutic application within the central nervous system
    • Whitesell, L., Geselowitz, D., Chavany, C., Fahmy, B., Walbridge, S., Alger, J. R. and Neckers, L. M. (1993) Stability, clearance and disposition of intraventriculary administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 90, 4665-4669.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 4665-4669
    • Whitesell, L.1    Geselowitz, D.2    Chavany, C.3    Fahmy, B.4    Walbridge, S.5    Alger, J.R.6    Neckers, L.M.7
  • 43
    • 0028618864 scopus 로고
    • Cellular uptake of intracerebroventricularly administered biotin-or digoxigenin labeled antisense oligodeoxynucleotides in the rat
    • Yee, F., Ericson, H., Reis, D. J. and Wahlstedt, C. (1994) Cellular uptake of intracerebroventricularly administered biotin-or digoxigenin labeled antisense oligodeoxynucleotides in the rat. Cell. Mol. Neurobiol. 14, 475-487.
    • (1994) Cell. Mol. Neurobiol. , vol.14 , pp. 475-487
    • Yee, F.1    Ericson, H.2    Reis, D.J.3    Wahlstedt, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.