Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension

Digestive Diseases and Sciences

Volumn 45, Issue 12, 2000, Pages 2405-2410

  Schroeder, R A ^a,b   Ewing, C A ^a,b   Sitzmann, J V ^a,b   Kuo, P C ^a,b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Heme oxygenase; Nitric oxide synthase; Portal hypertension

Indexed keywords

HEME OXYGENASE; NITRIC OXIDE SYNTHASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; LIVER FUNCTION; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PATHOGENESIS; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CYCLIC GMP; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HYPERTENSION, PORTAL; IMMUNOHISTOCHEMISTRY; LUNG; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; UP-REGULATION;

EID: 0034465937     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005651327654     Document Type: Article

References (19)

1. Washington MK: Pulmonary vascular morphological changes in cirrhotic patients undergoing liver transplantation
2. Distinctive clinical features of portopulmonary hypertension
3. Endothelin-1 in the rat bile duct ligation model of hepatopulmonary syndrome: Correlation with pulmonary dysfunction
4. Pulmonary function abnormality in patients with portal hypertension with or without chronic liver disease
5. Increased expression of endothelin receptors in the vaculature of portal hypertensive rats: Role in splanchnic hemodynamics
6. Enhanced nitric oxide synthase activity in portal hypertensive rabbits
7. Nitric oxide decreases oxidant mediated hepatocyte injury
8. Interleukin-1 induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes
9. Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
10. NO over production by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
11. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats
12. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus portal hypertension in rats
13. Vascular nitric oxide production during the development of two experimental models of portal hypertension
14. Upregulation of endothelial constitutive NOS: A major role in the increased NO production in cirrhotic rats
15. Endothelin-1 stimulation of endothelial nitric oxide synthase in the pathogenesis of hepatopulmonary syndrome
16. Increased heme-oxygenase- 1 gene expression in liver cells and splanchnic organs from portal hypertensive rats
17. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation
18. Induction of ferritin and heme oxygenase-1 by endotoxin in the the lung
19. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury