Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia

Molecular and Cellular Biology

Volumn 20, Issue 23, 2000, Pages 8655-8666

  Reuther, G W ^a   Lambert, Q T ^a   Caligiuri, M A ^a   Der, C J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE A; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; DELETION MUTANT; DNA LIBRARY; DNA TRANSFER; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION; GENE ISOLATION; GENE MUTATION; GENETIC CODE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; WESTERN BLOTTING;

3T3 CELLS; ACUTE DISEASE; ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INTERLEUKIN-3; LEUKEMIA, MYELOID; MICE; MUTATION; PROTO-ONCOGENES; RATS; RECEPTOR, TRKA; SEQUENCE DELETION;

EID: 0034462588     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.23.8655-8666.2000     Document Type: Article

References (76)

1. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
2. Neurotrophic factors and their receptors
3. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors
4. High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma
5. The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins
6. Ras oncogenes in human cancer: A review
7. Mutations in N-ras predominate in acute myeloid leukemia
8. Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product
9. Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins
10. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning
11. Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: Conditional regulation of c-myc transcription by temperature-sensitive v-abl
12. V-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells
13. Quantitation of rare cDNAs by PCR
14. Molecular cloning of a new transforming gene from a chemically transformed human cell line
15. Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis
16. The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway
17. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain
18. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
19. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses
20. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
21. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain
22. IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line
23. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)
24. Transforming genes of human hematopoietic tumors: Frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype
25. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
26. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
27. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas
28. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines
29. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1
30. Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase
31. Expression of the nerve growth factor receptor c-TRK in human myeloid leukaemia cells
32. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
33. The trk proto-oncogene product: A signal transducing receptor for nerve growth factor
34. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
35. Signal transduction by the neurotrophin receptors
36. Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
37. The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells
38. The trk proto-oncogene encodes a receptor for nerve growth factor
39. Trks: Signal transduction and intracellular pathways
40. Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non-neuronal carcinomas
41. Distribution of NGF receptors in normal and pathologic human lymphoid tissues
42. Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line
43. Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line
44. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia
45. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
46. Molecular and biochemical characterization of the human trk proto-oncogene
47. Alteration of growth and differentiation factors response by Kirsten and Harvey sarcoma viruses in the IL-3-dependent murine hematopoietic cell line 32D C13(G)
48. Oncogene ect2 is related to regulators of small GTP-binding proteins
49. Clinical manifestations of acute myeloid leukemia
50. Identification and biochemical characterization of p70TRK, product of the human TRK oncogene
51. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
52. High frequency of N-ras activation in acute myelogenous leukemia
53. Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex
54. Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences
55. Neurotrophin receptors, tumor progression and tumor maturation
56. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
57. Production of high-titer helper-free retroviruses by transient transfection
58. Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line
59. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
60. The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor
61. Differential utilization of Trk autophosphorylation sites
62. Three human transforming genes are related to the viral ras oncogenes
63. -/- mice: A direct role for Stat5 in Bcl-X(L) induction
64. Interleukin 3-dependent survival by the Akt protein kinase
65. Activation of a novel human transforming gene, ret, by DNA rearrangement
66. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
67. Cell cycle-dependent activation of Ras
68. Regulation of RasGRP via a phorbol ester-responsive C1 domain
69. Isolation of oncogenes from rat mammary tumors by a highly efficient retrovirus expression cloning system
70. Jun: Oncogene and transcription factor
71. TrkA glycosylation regulates receptor localization and activity
72. Expression cloning of oncogenes by retroviral transfer of cDNA libraries
73. Expression cloning of lsc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C
74. Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors
75. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
76. G2A is an oncogenic G protein-coupled receptor