Immune responses to DNA in normal and aberrant immunity

Immunologic Research

Volumn 22, Issue 2-3, 2000, Pages 119-126

  Pisetsky, David S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anti DNA; Autoimmunity; Cytokines; DNA; Immune Activation; Immune Suppression; Mitogenesis

Indexed keywords

AUTOANTIBODY; CYTOKINE; DNA; DNA ANTIBODY;

ANTIGENICITY; AUTOIMMUNE DISEASE; BACTERIUM; CONFERENCE PAPER; GENETIC HETEROGENEITY; IMMUNE RESPONSE; IMMUNITY; IMMUNOMODULATION; IMMUNOREGULATION; INFECTION; MAMMAL; MITOGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPECIES DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, BACTERIAL; DNA; DNA, BACTERIAL; HUMANS; IMMUNE SYSTEM; INTERLEUKIN-12; LUPUS ERYTHEMATOSUS, SYSTEMIC;

EID: 0034448276     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:22:2-3:119     Document Type: Article

References (28)

1. Immunological properties of DNA
2. Immune activation by bacterial DNA: A new genetic code
3. Anti-DNA antibodies in systemic lupus erythematosus
4. Antibodies to DNA
5. Responsiveness of autoimmune and normal mice to nucleic acid antigens
6. Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus
7. Specificity analysis of antibodies to single-stranded micrococcal DNA in the sera of normal human subjects and patients with systemic lupus erythematosus
8. Patterns of heavy and light chain utilization in the antibody response to singestranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus
9. Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE)
10. Induction of antidouble stranded DNA antibodies in normal mice by immunization with bacterial DNA
11. The antibody response of normal mice to immunization with single-stranded DNA of various species origin
12. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
13. Unique palindromic sequences in synthetic oligonucleotides are required to induce INF and augment INF-mediated natural killer activity
14. CpG motifs in bacterial DNA trigger direct B-cell activation
15. Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
16. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon γ
17. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
18. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
19. Influence of backbone chemistry on immune activation by synthetic oligonucleotides
20. The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens
21. The influence of base sequence on the immunological properties of defined oligonucleotides
22. Mitogenicity of DNA from different organisms for murine B cells
23. The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors
24. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
25. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA
26. Genetic and structural evidence for antigen selection of anti-DNA antibodies
27. Induction of cross-reaction anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA
28. Deficient expression of antibodies specific for bacterial DNA by patients with systemic lupus erythematousus