Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae

Infection and Immunity

Volumn 65, Issue 8, 1997, Pages 3352-3360

  Cadavid, Diego ^a,d   Pennington, Pamela M ^a   Kerentseva, Tatiana A ^a,b   Bergström, Sven ^c   Barbour, Alan G ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UMEÅ UNIVERSITY   (Sweden)

^d GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ARTICLE; BORRELIA; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; SEROTYPE;

EID: 0030841966     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.8.3352-3360.1997     Document Type: Article

References (44)

1. Altschul, S., W. Gish, W. Miller, E. Myers, and D. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Barbour, A. 1990. Antigenic variation of a relapsing fever Borrelia species. Annu. Rev. Microbiol. 44:155-171.
3. Barbour, A. 1985. Clonal polymorphisms of surface antigens in a relapsing fever Borrelia spp., p. 235-245. In G. Jackson (ed.), Pathogenesis of bacterial infection. Springer-Verlag KG, Heidelberg, Germany.
4. Barbour, A., C. Carter, V. Bundoc, and J. Hinnebusch. 1996. The nucleotide sequence of a linear plasmid of Borrelia burgdorferi reveals similarities to those of circular plasmids of other prokaryotes. J. Bacteriol. 178:6635-6639.
5. Barbour, A. G. 1984. Isolation and cultivalion of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
6. Barbour, A. G., O. Barrera, and R. C. Judd. 1983. Structural analysis of the variable major proteins of Borrelia hermsii. J. Exp. Med. 158:2127-2140.
7. Barbour, A. G., N. Burman, C. J. Carter, T. Kitten, and S. Bergstrom. 1991. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5:489-193.
8. Barbour, A. G., and S. F. Hayes. 1986. Biology of Borrelia species. Microbiol. Rev. 50:381-400.
9. Barbour, A. G., S. L. Tessier, and S. F. Hayes. 1984. Variation in a major surface protein of Lyme disease spirochetes. Infect. Immun. 45:94-100.
10. Barbour, A. G., S. L. Tessier, and H. G. Stoenner. 1982. Variable major proteins of Borrelia hermsii. J. Exp. Med. 156:1312-1324.
11. Barstad, P. A., J. E. Coligan, M. G. Raum, and A. G. Barbour. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161:1302-1314.
12. Burman, N., S. Bergström, B. I. Restrepo, and A. G. Barbour. 1990. The variable antigens Vmp7 and Vmp21 of the relapsing fever Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Mol. Microbiol. 4:1715-1726.
13. Cadavid, D., and A. G. Barbour. Neurologic manifestations of relapsing fever: comparative, clinical, and pathologic aspects. Clin. Infect. Dis., in press.
14. Cadavid, D., V. Bundoc, and A. Barbour. 1993. Experimental infection of the mouse brain by a relapsing fever Borrelia species: a molecular analysis. J. Infect. Dis. 168:143-151.
15. Cadavid, D., D. D. Thomas, R. Crawley, and A. G. Barbour. 1994. Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J. Exp. Med. 179:631-642.
16. Carter, C. J., S. Bergstrom, S. J. Norris, and A. G. Barbour. 1994. A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect. Immun. 62:2792-2799.
17. Dunn, J. J., B. N. Lade, and A. G. Barbour. 1990. Outer surface protein (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level of expression and purification of a soluble recombinant form of OspA. Protein Expression Purif. 1:159-168.
18. Fukunaga, M., Y. Takahashi, Y. Tsurata, O. Matsushita, D. Ralph, M. McClelland, and M. Nakao. 1995. Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector of Lyme disease in Japan. Int. J. Syst. Bacteriol. 45:804-810.
19. Hanahan, D. 1983. Studies of transformation of Eseherichia coli with plasmids. J. Mol. Biol. 166:557-580.
20. Higgins, D., and P. Sharp. 1988. CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. Gene 73:237-244.
21. Kennedy, P. 1992. Molecular studies of viral pathogenesis in the central nervous system. J. R. Coll. Physicians London 26:204-214.
22. Kitten, T., and A. G. Barbour. 1990. Juxtaposition of expressed variable antigen genes with a conserved telomere in ihe bacterium Borrelia hermsii. Proc. Natl. Acad. Sci. USA 87:6077-6081.
23. Kitten, T., A. V. Barrera, and A. G. Barbour. 1993. Intragenic recombination and a chimeric outer membrane protein in the relapsing fever agent Borrelia hermsii. Bacteriol. 175:2516-2522.
24. Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
25. Margolis, N., D. Hogan, W. Cieplak, T. Schwan, and P. Rosa. 1994. Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. Gene 143:105-110.
26. Meier, J., M. Simon, and A. G. Barbour. 1985. Antigenic variation is associated with DNA rearrangement in a relapsing fever borrelia. Cell 41:403-407.
27. Norris, S. J., C. J. Carter, J. K. Howell, and A. G. Barbour. 1992. Low-passage-associated proteins of Borrelia burgdorferi: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein. Infect Immun. 60:4662-4672.
28. Oi, V. T., and L. A. Herzenberg. 1980. Immunoglobulin-producing hybrid cell lines, p. 351-372. In S. M. Shiigis (ed.), Selected methods in cellular immunology. W. H. Freeman & Co., San Francisco, Calif.
29. Pachner, A. 1986. Spirochetal diseases of the CNS. Neurol. Clin. North Am. 4:207-222.
30. Pennington, P., C. D. Allred, D. Cadavid, S. Norris, and A. G. Barbour. 1997. Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease. Infect Immun. 65:285-292.
31. Plasterk, R. H., M. I. Simon, and A. G. Barbour. 1985. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature 318:257-263.
32. Restrepo, B. I., and A. G. Barbour. 1994. Antigen diversity in the bacterium Borrelia hermsii through "somatic" mutations in rearranged vmp genes. Cell 78:867-876.
33. Restrepo, B. I., C. J. Carter, and A. G. Barbour. 1994. Activation of a vmp pseudogene in Borrelia hermsii: an alternate mechanism of antigenic variation during relapsing fever. Mol. Microbiol. 13:287-299.
34. Restrepo, B. I., C. J. Carter, T. Kitten, and A. G. Barbour. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6:3299-3311.
35. Sadziene, A., P. A. Rosa, P. A. Thompson, D. M. Hogan, and A. G. Barbour. 1992. Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization. J. Exp. Med. 176:799-809.
36. Sadziene, A., D. D. Thomas, V. G. Bundoc, S. H. Holt, and A. G. Barbour. 1991. A flagella-less mutant of Borrelia burgdorferi. J. Clin. Invest. 88:82-92.
37. Sadziene, A., B. Wilske, M. S. Ferdows, and A. G. Barbour. 1993. The cryptic OspC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect. Immun. 61:2192-2195.
38. Seelig, A., R. Gottschlich, and R. M. Devant. 1994. A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc. Natl. Acad. Sci. USA 91:68-72.
39. Stoenner, H. G., T. Dodd, and C. Larsen. 1982. Antigenic variation of Borrelia hermsii. J. Exp. Med. 156:1297-1311.
40. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties, and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
41. Tyler, K. L., R. T. Bronson, K. B. Byers, and B. Fields. 1985. Molecular basis of viral neurotropism: experimental reovirus infection. Neurology 35:88-92.
42. van Dam, A., H. Kuiper, K. Vos, A. Widjojokusumo, B. de Jongh, L. Spanjaard, A. Ramselaar, M. Kramer, and J. Dankert. 1993. Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis. Clin. Infect. Dis. 17:708-717.
43. von Heijne, G. 1983. Patterns of amino acids near signal sequence cleavage sites. Eur. J. Biochem. 133:17-21.
44. Wilske, B., V. Preac-Mursic, S. Jauris, I. Pradel, E. Soutschek, E. Schwab, and G. Wanner. 1993. Immunological and molecular polymorphism of OspC: an immunodominant major outer surface protein of Borrelia burgdorferi. Infect. Immun. 61:2182-2191.