Roles of mitochondrial dysfunctions in Alzheimer's disease: Contribution of deficiency of ALDH 2

Clinical Neurology

Volumn 40, Issue 12, 2000, Pages 1231-1233

  Ohta, S ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Aldehyde dehydrogenase; Alzheimer's disease; Apolipoprotein E; Mitochondria; Oxidative stress

Indexed keywords

ALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HOMOZYGOSITY; HUMAN; JAPAN; MAJOR CLINICAL STUDY; METABOLISM; MITOCHONDRION; ONSET AGE; REGRESSION ANALYSIS; RISK FACTOR;

AGE OF ONSET; ALDEHYDE DEHYDROGENASE; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; GENOTYPE; HUMANS; JAPAN; MITOCHONDRIA; MUTATION; OXIDATIVE STRESS; RISK;

EID: 0034436476     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Human aldehyde dehydrogenase family
2. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues
3. Molecular abnormality of an inactive aldehyde dehydrogenase variant com-monly found in Orientals
4. The mutation in the mitochondrial aldehyde dehydrogenase (ALDH 2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion
5. Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2
6. A full genome scan for late onset Alzheimer's disease
7. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population
8. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in alte onset families
9. Association of apolipoprotein-E allele ε 4 with late-onset familial and sporadic Alzheimer's disease