Synthesis and evaluation of Asperlicin analogues as non-peptidal cholecystokinin-antagonists

Drug Design and Discovery

Volumn 17, Issue 3, 2000, Pages 219-230

  Lattmann, E ^a   Billington, D C ^a   Poyner, D R ^a   Howitt, S B ^a   Offel, M ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

1,4 Benzodiazepines; Asperlicin; Indole; Lead structure; Natural product; Non peptide CCK antagonists; Substructure

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 3 INDOL 3' YLMETHYL 1,4 BENZODIAZEPINE 2 ONE DERIVATIVE; 4 [[2 [2 [[(2 ADAMANTYLOXY)CARBONYL]AMINO] 3 (1H INDOL 3 YL) 2 METHYLPROPIONAMIDO] 1 PHENYLETHYL]AMINO] 4 OXOBUTYRIC ACID MEGLUMINE; ACETOPHENONE DERIVATIVE; ASPERLICIN; BENZODIAZEPIN 2 ONE DERIVATIVE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; GUINEA PIG; MALE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BENZODIAZEPINONES; CHOLECYSTOKININ; GUINEA PIGS; MALE; RECEPTORS, CHOLECYSTOKININ; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034435822     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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