Design and synthesis of novel nonpeptide CCK-B receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 7, 1997, Pages 805-810

  Padia, J K ^a   Chilvers, H ^b   Daum, P ^b   Pinnock, R ^b   Suman Chauhan, N ^b   Webdale, L ^b   Trivedi, B K ^a  

^a PFIZER INC   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERLICIN; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; QUINAZOLINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; MOUSE; NONHUMAN; PANCREAS; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0030936874     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00108-X     Document Type: Article

References (17)

1. Crawley, J. N. Trends Pharmacol Sci. 1991, 12, 232.
2. Woodruff, G. N.; Hughes, J. Annu. Rev. Pharmacol. Toxicol. 1991, 31, 469.
3. For reviews, see: (a) Trivedi, B. K. Current Med. Chem. 1994, 1, 313,
4. (b) Trivedi, B. K. Curr. Opin. Ther. Patents. 1994, 4, 31
5. Horwell, D. C.; Hughes, J.; Hunter, J. C.; Pritchard, M. C.; Richardson, R. S.; Roberts, E.; Woodruff, G. N. J. Med. Chem. 1991, 34, 404.
6. Trivedi, B. K.; Padia, J. K.; Holmes, A.; Rose, S.; Wright, S. D.; Hinton, J. P.; Prichard, M. C.; Eden, J. M.; Kneen, C.; Webdale, L.; Suman-Chuhan, N.; Boden, P.; Singh, L.; Field. M. J.; Hill, D. R. J. Med. Chem. (Submitted).
7. Chang, R. S. L.; Lotti, V. J.; Monaghan, R. L.; Birnbaum, J.; Stapley, E. O.; Goetz, M. A.; Albers-Schonberg, G.; Patchett, A. A.; Liesch, J. M.; Hensens, O. D.; Springer, J. P. Science 1985, 230, 177.
8. Bock, M. G.; DiPardo, R. M.; Evans, B. E.; Rittle, K. E.; Whitter, W. L.; Veber, D. F.; Anderson, P. S.; Freidinger, R. M. J. Med. Chem. 1989, 32, 13.
9. Yu, M. J.; Thrasher, K. J.; McCowan, J. R.; Mason, N. R.; Mendelsohn, L. G. J. Med. Chem. 1991, 34, 1508.
10. Yu, M. J.; McCowan, J. R.; Mason, N. R.; Deeter, J. B.; Mendelsohn, L. G. J. Med. Chem. 1992, 35, 2534.
11. Abdel-Megeid, F. M. E.; Elkaschef, M. A. F.; Mokhatar, K. E. M.; Zaki, K. E. M. J. Chem. Soc. (C). 1971, 1055.
12. British Patent No. 1,038,729. 1966. CAN 65: 15399g
13. U. S.Patent No. 3,867,384,1975. CAN 82: 171037
14. Kottke, K.; Kuehmstedt, H. Pharmazie, 1980, 35, 800.
15. All new compounds gave satisfactory spectral and elemental analyses. We acknowledge staff of the analytical department for spectral and analytical services.
16. Howbert, J. J.; Lobb, K. L.; Britton, T. C.; Mason, N. R.; Burns, R. F. J. Med. Chem., 1993, 3, 875.
17. Pinnock, R.; Suman-Chauhan, N.; Daum, P.; Hill, D. R.; Woodruff, G. N. Neuropeptide, 1994, 27, 175.