Cholesterol-lowering effect of plant sterols

European Journal of Lipid Science and Technology

Volumn 102, Issue 1, 2000, Pages 37-44

  Wester, Ingmar ^a  

^a Raisio Oyj   (Finland)

Author keywords

Cholesterol absorption; Plant stanol ester; Plant sterols; Serum cholesterol

Indexed keywords

EID: 0034341575     PISSN: 14387697     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1438-9312(200001)102:1<37::aid-ejlt37>3.0.co;2-1     Document Type: Article

References (29)

1. th Nordic Lipid Symposium, Imatra, Finland. Ed. Y. Mälkki and G. Lambertsen. Lipid-forum, Bergen (Norway), pp. 14-19.
2. D. W. Peterson: Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc. Soc. Exp. Biol. Med. 78 (1951) 143-147.
3. O. J Pollak: Prevention of hypercholesterolemia in rabbit. Successful prevention of cholesterol atherosclerosis. Reduction of blood cholesterol in man. Circulation 6 (1952) 459-460.
4. O. J. Pollak, D. Kritchevsky: Sitosterol. In: Mono.gr. Atheroscler. 10, 1-219. Eds T. B. Clarkson, D. Kritchevsky, O. J. Pollak. Karger, Basel (Switzerland), 1981.
5. O. J. Pollak. Effect of plant sterols on serum lipids and atherosclerosis. Pharm. Ther. 31 (1985) 177-208.
6. W. H. Ling, P. J. H. Jones: Dietary phytosterols: A review of metabolism, benefits and side effects. Life Sci. 57 (1995) 195-207.
7. P.J.H. Jones, D.E. Macdougall, F. Ntatnios, C.A. Vanstone: Dietary phytosterols as cholesterol-lowering agents in humans. Can. J. Physiol. Pharmacol. 75 (1997) 217-227.
8. S. M. Grundy, H. Y. I. Mok: Optimizing the effect on cholesterol absorption in man. J. Lipid Res. 18 (1997) 263-271.
9. A. M. Lees, H.Y.I. Mok, P.S. Lees, M.A. McCluskey, S.M. Grundy: Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28 (1977) 325-338
10. M. F. Sugano, I. Kamo, I. Ikeda, H. Morioko: Lipid-lowering activity of phylostanols in rats. Atherosclerosis 24 (1976) 301-309.
11. I. Ikeda, A. Kawasaki, K. Samezima, M. Sugano: Antihypercholesterolemic activity of β-sitostanol in rabbits. J. Nutr. Sci. Vitaminol. 27 (1981) 243-251.
12. T. Heinemann, G. Axtmann, K. von Bergmann: Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest. 23 (1993) 827-831.
13. M. Becker, D. Staab, K. von Bergmann: Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J. Pediatrics 122 (1993) 292-296. 44 Wester
14. F. H. Mattson, S. M. Grundy, J. R. Crouse: Optimizing the effect of plant sterols on cholesterol absorption in man. Am. J. Clin. Nutr. 35 (1982) 697-700.
15. I. Ikeda, Y. Tanabe, M. Sugano: Effects of sitosterol and sitostanol on micellar solubility of cholesterol. J. Nutr. Sci. Vitaminol. 35 (1989) 361-369.
16. T. A. Miettinen, H. Gylling: Sitostanol-ester margarine. In: New Technologies for Heatlhy Foods and Nutraceuticals. Ed: M. Yalpani. ATL Press, 1997, pp. 71-83.
17. R.P. Mensink, J. Plat: Efficacy of dietary plant stanols. Post-gr. Med. A Special Report 1998; November 27-31.
18. T. A. Miettinen, H. Gylling: Regulation of cholesterol metabolism by dietary plant sterols. Curr. Opin. Lipidol. 10 (1999) 9-14.
19. T. A. Miettinen, P. Puska, H. Gylling, H. Vanhanen, E. Vartiainen: Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N. Engl. J. Med. 333 (1995) 1308-1312.
20. M.A. Hallikainen, M.I.J. Uusitupa: Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolmic subjects. Am. J. Clin. Nutr. 69 (1999) 411-418.
21. H. Gylling, R. Radhakrishnan, T.A. Miettinen: Reduction of serum cholesterol in postmenopausal women with revious myocardial infarction and cholesterol malabsorbtion induced by dietary sitstanol ester margarine, Circulation 96 (1997) 4226-4231.
22. H.T. Vanhanen, J. Kajander, H. Lehtovirta, T.A. Miettinen: Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol ester in hypercholesterolaemic subjects. Clin. Sci. 87 (1994) 61-47.
23. D. Lütjohann, I. Björkhem, U. F. Beil, K. von Bergmann: Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. J. Lipid Res. 36 (1995) 1763-1773.
24. W. H. Ling, P. J. H. Jones: Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats, Atherosclerosis 118 (1995) 319-331.
25. F. Y. Ntanios, P. J. H. Jones, J. J. Frohlich: Dietary sitostanol reduces plaque formation but not lecithine cholesterol acyl transferase activity in rabbits. Atherosclerosis 138 (1998) 101-110.
26. F.Y. Ntanios, P.J.H. Jones: Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterols metabolism in hamsters. Biochim. Biophys. Acta 1390 (1998) 237-244.
27. J. A. Weststrate, G. W. Meijer. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolemic and mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr 52 (1998) 334-343.
28. N. Rong, L. M. Ausman, R. J. Nicolosi: Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 32 (1997) 303-309.
29. W. H. Yokoyama, T. E. Fitch: Rice bran oil, but not rice bran, reduces bioavailability of dietary cholesterol and reduces plasma cholesterol in hamsters, 1998 AACC Annual Meeting September 13-17, Minneapolis, Minnesota, Abstract 333.