Papel de la vía aérea superior en la patogenia del síndrome de apneas obstructivas del sueño

Archivos de Bronconeumologia

Volumn 36, Issue 10, 2000, Pages 574-579

  Carrera, M ^a   Barbe F ^a   Agusti A G N ^a  

^a HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; BREATHING MECHANICS; DIAPHRAGM; HISTOLOGY; HUMAN; MANDIBLE; MUSCLE RELAXATION; OBESITY; PHARYNX; PHYSIOLOGY; REVIEW; SKELETAL MUSCLE; SLEEP APNEA SYNDROME;

AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; DIAPHRAGM; HUMANS; MANDIBLE; MUSCLE RELAXATION; OBESITY; PHARYNGEAL MUSCLES; PHARYNX; RESPIRATORY MECHANICS; SLEEP APNEA SYNDROMES;

EID: 0034327333     PISSN: 03002896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-2896(15)30100-9     Document Type: Review

References (70)

1. Hudgel DW. Mechanisms of obstructive sleep apnea. Chest 1992; 101: 541-549.
2. Hudgel DW, Martin RJ, Johnson B, Hill P. Mechanics of the respiratory system and breathing pattern during sleep in normal humans. J Appl Physiol 1984; 56: 133-137.
3. Wiegand L, Zwillich C, White DP. Collapsibility of the human upper airway during normal sleep. J Appl Physiol 1989; 66: 1800-1809.
4. Sforza E, Petiau C, Weiss T, Thibault A, Krieger J. Pharyngeal critical pressure in patients with obstructive sleep apnea syndrome. Clinical implications. Am J Respir Crit Care Med 1999; 159: 149-157.
5. Pendlebury ST, Pepin JL, Veale D, Levy P. Natural evolution of moderate sleep apnoea syndrome: significant progression over a mean of 17 months. Thorax 1997; 52: 872-878.
6. Friberg D, Ansved T, Borg K, Carlson-Nordlander B, Larsson H, Svanborg E. Histological indications of a progresive snorers disease in an upper airway muscle. Am J Respir Crit Care Med 1998; 157: 586-593.
7. Shelton KE, Gay SB, Hollowell DE, Woodson H, Suratt PM. Mandible enclosure of upper airway and weight in obstructive sleep apnea. Am Rev Respir Dis 1993; 148: 195-200.
8. Horner RL, Mohiaddin RH, Lowell DG, Shea SA, Burman ED, Longmore DB et al. Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls. Eur Respir J 1989; 2: 613-622.
9. Bradley TD, Brown IG, Gossman RF, Zamel N, Martinez D, PhiIlipson EA et al. Pharyngeal size in snorers, nonsnorers, and patients with obstructive sleep apnea. N Engl J Med 1986; 315: 1327-1331.
10. Shelton KE, Woodson H, Gay S, Suratt PM. Pharyngeal fat in obstructive sleep apnea. Am Rev Respir Dis 1993; 148: 462-466.
11. Katz I, Stradling J, Slutsky AS, Zamel N, Hoffstein V. Do patients with obstructive sleep apnea have thick necks? Am Rev Respir Dis 1990; 141: 1228-1231.
12. Davies RJ, Stradling JR. The relationship between neck circumference, radiographic pharyngeal anatomy, and the obstructive sleep apnoea syndrome. Eur Respir J 1990; 3: 509-514.
13. Stauffer JL, Buick MK, Bixler EO, Sharkey FE, Abt AB, Manders EK et al. Morphology of the uvula in obstructive sleep apnea. Am Rev Respir Dis 1989; 140: 724-728.
14. Mortimore IL, Marshall I, Wraith PK, Sellar RJ, Douglas NJ. Neck and total body fat deposition in nonobese and obese patients with sleep apnea compared with that in control subjects. Am J Respir Crit Care Med 1998; 157: 280-283.
15. Grunstein RR, Wilcox I. Sleep-disordered breathing and obesity. Bailliere's Clinical Endocrinology 1994; 8: 601-628.
16. Whittle IT, Marshall I, Mortimore IL, Wraith PK, Sellar RJ, Douglas NJ. Neck soft tissue and fat distribution: comparison between normal men and women by magnetic resonance imaging. Thorax 1999; 54: 323-328.
17. Koenig JS, Thach B. Effects of mass loading on the upper airway. J Appl Physiol 1998; 64: 2294-2299.
18. Rodenstein DO, Dooms G, Thomas Y, Liistro G, Stanescu DC, Culée C et al. Pharyngeal shape and dimensions in healthy subjects, snorers and patients with obstructive sleep apnoea. Thorax 1990; 45: 722-727.
19. Leiter JC. Upper airway shape. Is it important in the pahogenesis of obstructive sleep apnea? Am J Respir Crit Care Med 1996; 153: 894-898.
20. Jokic R, Klimaszewski A, Mink J, Fitzpatrick F. Surface tension forces in sleep apnea: the role of a soft tissue lubricant. Am J Respir Crit Care Med 1998; 157: 1522-1525.
21. Wheatley JR, White DP. The influence of sleep on pharyngeal reflexes. Sleep 1993; 16: S87-S89.
22. Deegan PC, Mulloy E, McNicholas WT. Topical oropharyngeal anesthesia in patients with obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151: 1108-1112.
23. Friberg D, Gazelius B, Hokfelt T, Nordlander B. Abnormal afferent nerve endings in the soft palatal mucosa of sleep apneics and habitual snorers. Regul Pept 1997; 71: 29-36.
24. Rowley JA, Zahn BR, Babcock MA, Badr M. The effect of rapid eye movement (REM) sleep on upper airway mechanics in normal human subjects. J Physiol (London) 1998; 510: 963-976.
25. a ed.). Londres: Saunders Co, 1994; 212-223.
26. Dempsey JA, Smith CA, Harms CA, Chow C, Saupe KW. Sleep-induced breathing instability. Sleep 1996; 19: 236-247.
27. a ed.). Londres: WB Saunders Co., 1994; 163-175.
28. Lopes JM, Tabachnik E, Muller NL. Total airway resistance and respiratory muscle activity during sleep. J Appl Physiol 1983; 54: 773-777.
29. Berry RB, Gleeson K. Respiratory arousal from sleep: mechanisms and significance. Sleep 1997; 20: 654-675.
30. Henke KG, Badr MS, Skatrud JB, Dempsey JA. Load compensation and respiratory muscle function during sleep. J Appl Physiol 1992; 72: 1221-1234.
31. Block JA, Faulkner JA, Hughes RL, Remmers JE, Thach B. Factors influencing upper airway closure. Chest 1984; 86: 114-122.
32. Kimura H, Niijima M, Edo H, Tatsumi K, Honda Y, Kuriyama T. The effect of hypoxic depression on genioglossal muscle activity in healthy subjects and obstructive sleep apnea patients. Sleep 1993; 16: S135-S136.
33. Somers VK, Abboud FM. Chemoreflexes-responses, interactions and implications for sleep apnea. Sleep 1990; 16: S30-S34.
34. a ed.). Londres: WB Saunders Company, 1994; 642-656.
35. Mortimore IL, Douglas NJ. Palatal muscle EMG response to negative pressure in awake sleep apneic and control subjects. Am J Respir Crit Care Med 1997; 156: 867-873.
36. Horner RL, Innes A, Guz A. Reflex pharyngeal dilator muscle activation by stimuli of negative airway pressure in awake man. Sleep 1993; 16: S85-S86.
37. Mathew OP. Upper airway negative-presure effects on respiratory activity of upper airway muscles. J Appl Physiol 1984; 56: 500-505.
38. Van Lunteren E, Strohl KP. The muscles of the upper airway. Clin Chest Med 1986; 7: 171-181.
39. Van Lunteren E. Upper-airway effects on breathing. En: Crystal RG, West JB, Barnes PJ, Cherniak NS, Weibel ER, editores. The lung: scientific foundations. Nueva York: Raven Press, 1991; 1631-1643.
40. Hudgel DW. The role of upper airway anatomy and physiology in obstructive sleep apnea. Clin Chest Med 1992; 13: 383-398.
41. Tangel DJ, Mezzanotte WS, White DP. The influence of sleep on tensor palatini EMG and upper airway resistance in normal subjects. J Appl Physiol 1991; 70: 2574-2581.
42. Skatrud JB, Dempsey JA. Airway resistance and respiratory muscle function in snorers during NREM sleep. J Appl Physiol 1985; 59: 328-335.
43. Wheatley JR, Mezzanotte WS, Tangel DJ, White DP. Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis 1993; 148: 597-605.
44. Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest 1992; 89: 1571-1579.
45. Douglas NJ, Polo O. Pathogenesis of obstructive sleep apnoea/hypopnoea syndrome. Lancet 1994; 344: 653-655.
46. Remmers JE, DeGroot WJ, Sauerland EK, Anch AM. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 1978; 44: 931-938.
47. Hendricks JC, Petrof BJ, Panckeri K, Pack AI. Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs. Am Rev Respir Dis 1993; 148: 185-194.
48. Petrof BJ, Hendricks JC, Pack AI. Does Upper airway muscle injury trigger a vicious cycle in obstructive sleep apnea? A hypothesis. Sleep 1996; 19: 465-471.
49. Ferini-Strambi L, Smirne S, Moz H, Sferrazza B, Iannaccone S. Muscle fibre type and obstructive sleep apnea. Sleep Online 1998; 1: 24-27.
50. Sériès F, Simoneau JA, St Pierre S, Marc I. Characteristics of the genioglossus and musculus uvulae in sleep apnea hypopnea syndrome and in snorers. Am J Respir Crit Care Med 1996; 153: 1870-1874.
51. Sériès F, Côté C, Simoneau J-A, Gélinas Y, St. Pierre S, Leclerc J et al. Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers. J Clin Invest 1995; 95: 20-25.
52. Guilleminault C, Stoohs R, Duncan S. Snoring (I). Daytime sleepiness in regular heavy snorers. Chest 1991; 99: 40-48.
53. Carrera M, Barbé F, Sauleda J, Tomás M, Gómez C, Agustí AGN. Patients with obstructive sleep apnea exhibit genioglossus dysfunction that is normalized after treatment with continuous positive airway pressure. Am J Respir Crit Care Med 1999; 159: 1960-1966.
54. Suratt PM, Metier RF, Wilhoit SC. Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared to that in normal subjects. Am Rev Respir Dis 1988; 137: 889-894.
55. Mathur R, Douglas NJ. Family studies in patients with the sleep apnea-hypopnea syndrome. Ann Intern Med 1995; 122: 174-178.
56. a ed.). Nueva York: Marcel Dekker Inc., 1994; 71: 363-378.
57. Redline S, Tishier PV, Tosteson TD, Williamson J, Kump K, Browner I et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151: 682-687.
58. Schwab RJ. Sex differences and sleep apnoea. Thorax 1999; 54: 284-285.
59. Bouchard C, Després JP, Mauriège P. Genetic and nongenetic determinants of regional fat distribution. Endocrine Rev 1999; 14: 72-93.
60. Strohl KP. Tumor necrosis factor and sleep apnea. Am J Respir Crit Care Med 1996; 153: 893.
61. Agustí AGN, Barbé F, Togores B. Exhaled nitric oxide in patients with sleep apnea. Sleep 1999; 22: 231-235.
62. Dzoljic MR, De Vries R, Van Leeuwen R. Sleep and nitric oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase. Brain Res 1996; 718: 145-150.
63. O'Donnell CP, Schaub CD, Haines AS, Berkowitz DE, Tankersley CG, Schwartz AR et al. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999; 159: 1477-1484.
64. Entzian P, Linnemann K, Schlaak M, Zabel P. Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 1996; 153: 1080-1086.
65. Hudgel DW, Thanakitcharu S. Pharmacologic treatment of sleep-disordered breathing. Am Rev Respir Dis 1998; 158: 691-699.
66. Behan M, Brownfield MS. Age-related changes in serotonin in the hypoglossal nucleus of rat: implications for sleep-disordered breathing. Neurosci Lett 1999; 267: 133-136.
67. Veasey SC, Panckeri KA, Hoffman EA, Pack AI, Hendricks JC. The effects of serotonin antagonists in an animal model of sleep-disordered breathing. Am J Respir Crit Care Med 1996; 153: 776-786.
68. Hudgel DW, Gordon EA. Serotonin-induced cortisol release in CPAP-treated obstructive sleep apnea patients. Chest 1997; 111: 632-638.
69. Kraiczi H, Hedner J, Dahlöf P, Ejnell H, Carlson J. Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep 1999; 22: 62-67.
70. Radulovacki M, Trbovic S, Carley DW. Serotonin 5-HT3-receptor antagonist GR 38032F Supresses sleep apneas in rats. Sleep 1998; 21: 131-136.