Palatal muscle EMG response to negative pressure in awake sleep apneic and control subjects

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 3 I, 1997, Pages 867-873

  Mortimore, Ian L ^a   Douglas, Neil J ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY PRESSURE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAM; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PALATE; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; STIMULUS RESPONSE; UPPER RESPIRATORY TRACT OBSTRUCTION;

EID: 0030870112     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.3.9608008     Document Type: Article

References (35)

1. Jennum, P., and A. Sjol. 1992. Epidemiology of snoring and obstructive sleep apnoea in a Danish population age 30-60. J. Sleep Res. 1:240-244.
2. Stradling, J. R., and J. H. Crosby. 1991. Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. Thorax 46:85-90.
3. Young, T., M. Palta, J. Dempsey, J. Skatrud, S. Webber, and S. Bader. 1993. The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med. 328:1230-1235.
4. Haraldsson, P.-O., C. Carenfelt, F. Diderichsen, A. Nygren, and C. Tingvall. 1990. Clinical symptoms of sleep apnea syndrome and automobile accidents. O.R.L. 52:57-62.
5. Phillipson, E. A. 1993. Sleep apnea - a major public health problem. N. Engl. J. Med. 328:1271-1273.
6. Remmers, J. E., W. J. De Groot, E. K. Sauerland, and A. M. Anch. 1978. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 44:931-938.
7. Douglas, N. J., and O. Polo. 1995. Pathogenesis of obstructive sleep apnoea/hypopnoea. Lancet 344:653-655.
8. Brown, I. G., T. D. Bradley, E. A. Phillipson, N. Zamel, and V. Hoffstein. 1985. Pharyngeal compliance in snoring subjects with and without obstructive sleep apnea. Am. Rev. Respir. Dis. 132:211-215.
9. Bradley, T. D., I. G. Brown, R. F. Grossman, N. Zamel, D. Martinez, and E. A. Phillipson. 1986. Pharyngeal size in snorers, nonsnorers and patients with obstructive sleep apnea. N. Engl. J. Med. 315:1327-1331.
10. Hoffstein, V., S. Wright, N. Zamel, and T. D. Bradley. 1991. Pharyngeal function and snoring characteristics in apneic and non-apneic snorers. Am. Rev. Respir. Dis. 143:1294-1299.
11. Rodenstein, D. O., G. Dooms, Y. Thomas, G. Liistro, D. C. Stanescu, C. Culec, and G. Aubert-Tulkens. 1990. Pharyngeal shape and dimension in healthy subjects, snorers, and patients with obstructive sleep apnoea. Thorax 45:722-727.
12. Suratt, P. M., R. F. McTier, and S. C. Wilhoit. 1988. Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects. Am. Rev. Respir. Dis. 137: 889-894.
13. Issa, F. Q., and C. E. Sullivan. 1984. Upper airway closing pressures in obstructive sleep apnea. J. Appl. Physiol. 57:520-527.
14. Morrison, D. L., S. H. Launois, S. Isono, T. R. Feronh, W. A. Whitelaw, and J. E. Remmers. 1993. Pharyngeal narrowing and closing pressures in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 148: 606-611.
15. Mortimore, I. L., R. Mathur, and N. J. Douglas. 1995. Effect of posture, route of respiration and negative pressure on palatal muscle activity in humans. J. Appl. Physiol. 79:448-454.
16. Johns, M. W. 1991. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14:540-545.
17. Douglas, N. J., M. A. Jan, N. Yildirim, P. M. Warren, and G. B. Drummond. 1993. The effect of posture and breathing route on genioglossal electromyogram activity in normal subjects and in patients with the sleep apnea/hypopnea syndrome. Am. Rev. Respir. Dis. 148:1341-1345.
18. Hairston, L. E., and E. K. Sauerland. 1981. Electromyography of the human palate: discharge patterns of the levator and tensor veli palatini. Electromyogr. Clin. Neurophysiol. 21:287-297.
19. Horner, R. L., J. A. Innes, and A. Guz. 1991. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressures in man. J. Physiol. (London) 436:15-29.
20. Fritzell, B. 1979. Electromyography in the study of velopharyngeal function - a review. Folia. Phoniat. 31:93-102.
21. Mezzanotte, W. S., D. J. Tangel, and D. P. White. 1992. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J. Clin. Invest. 89:1571-1579.
22. Carlson, D. M., E. Onal, D. W. Carley, M. Lopata, and R. C. Basner. 1995. Palatal muscle electromyogram activity in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 152:1022-1027.
23. Martin, S. E., I. Marshall, and N. J. Douglas. 1995. The effect of posture on airway caliber with the sleep apnea/hypopnea syndrome. Am. J. Respir. Crit. Care Med. 152:721-724.
24. Mathur, R., and N. J. Douglas. 1995. Family studies in patients with the sleep apnea-hypopnea syndrome. Ann. Intern. Med. 122:174-178.
25. Ferguson, K. A., T. Ono, A. A. Lowe, C. F. Ryan, and J. A. Fleetham. 1995. The relationship between obesity and craniofacial structure in obstructive sleep apnea. Chest 108:375-381.
26. Vanoye, C. R., S. T. Kuna, and K. G. Henke. 1995. Can genioglossus EMG be normalised? Am. J. Respir. Crit. Care Med. 151:A558.
27. Mortimore, I. L., and N. J. Douglas. 1996. Genioglossus strength and fatiguability: relationship to apnea/hypopnea index. Am. J. Respir. Crit. Care Med. 153:A532.
28. Mortimore, I. L., and N. J. Douglas. 1996. Relationship of genioglossus muscle electromyographic activity to force. Am. J. Respir. Crit. Care Med. 153:A690.
29. Suratt, P. M., S. C. Wilhoit, and K. Cooper. 1984. Induction of airway collapse with subatmospheric pressure in awake patients with sleep apnea. J. Appl. Physiol. 57:140-146.
30. Mortimore, I. L., P. Kochhar, and N. J. Douglas. 1996. Effect of chronic positive airway pressure (CPAP) therapy on upper airway size in patients with sleep apnoea/hypopnoea syndrome. Thorax 51:190-192.
31. Stauffer, J. L., M. K. Buick, E. O. Bixler, F. E. Sharkey, A. B. Abt, E. K. Manders, A. Kales, R. J. Cadieux, J. D. Barry, and C. W. Zwillich. 1989. Morphology of the uvula in obstructive sleep apnea. Am. Rev. Respir. Dis. 140:724-728.
32. Series, F., N. Roy, and I. Marc. 1994. Effects of sleep deprivation and sleep fragmentation on upper airway collapsibility in normal subjects. Am. J. Respir. Crit. Care Med. 150:481-485.
33. Series, F., C. Cote, J.-A. Simoneau, Y. Gelinas, S. St. Pierre, J. Leclere, R. Ferland, and I. Marc. 1995. Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers. J. Clin. Invest. 95:20-25.
34. Engleman, H. M., S. E. Martin, and N. J. Douglas. 1994. Compliance with CPAP therapy in patients with the sleep apnoea/hypopnoea syndrome. Thorax 49:263-266.
35. Kribbs, N. B., A. I. Pack, L. R. Kline, J. E. Getsy, J. S. Schuett, J. N. Henry, G. Maislin, and D. F. Dinges. 1993. Effects of one night without nasal CPAP treatment on sleep and sleepiness in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 147:1162-1168.