Growth of Legionella pneumophila in Dictyostelium discoideum: A novel system for genetic analysis of host-pathogen interactions

Trends in Microbiology

Volumn 8, Issue 10, 2000, Pages 478-480

  Solomon, Jonathan M ^a   Isberg, Ralph R ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; VIRULENCE FACTOR;

ANIMAL MODEL; BACTERIAL GROWTH; BACTERIAL INFECTION; CYTOSKELETON; DICTYOSTELIUM DISCOIDEUM; ELECTRON MICROSCOPY; GENETIC ANALYSIS; HOST PARASITE INTERACTION; IMMUNOFLUORESCENCE; LEGIONELLA PNEUMOPHILA; MODEL; MUTANT; NONHUMAN; PATHOGENESIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; TEMPERATURE;

ANIMAL; BACTERIOLOGICAL TECHNIQUES; DICTYOSTELIUM; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MUTATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

BACTERIA (MICROORGANISMS); DICTYOSTELIUM DISCOIDEUM; LEGIONELLA PNEUMOPHILA; NEGIBACTERIA;

EID: 0034307165     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(00)01852-7     Document Type: Review

References (21)

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4. Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions
5. Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells
6. A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii
7. Association of Legionella pneumophila with the macrophage endoplasmic reticulum
8. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
9. The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum
10. Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion
11. Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella
12. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
13. Conjugative transfer by the virulence system of Legionella pneumophila
14. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome
15. Evidence for pore-forming ability by Legionella pneumophila
16. Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells
17. Cell biological, molecular genetic and biochemical methods used to examine Dictyostelium
18. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development
19. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development
20. G protein beta subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton
21. Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila