Effects of hepatocellular mitogens on cytokine-induced nitric oxide synthesis in human hepatocytes

Journal of Leukocyte Biology

Volumn 60, Issue 3, 1996, Pages 382-388

  Liu, Zhi Ze ^a   Cui, Shijun ^d   Billiar, Timothy R ^a   Dorko, Kenneth ^a   Halfter, Willi ^b   Geller, David A ^a   Michalopoulos, George ^c   Beger, Hans G ^e   Albina, Jorge ^d   Nussler, Andreas K ^a,e  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

^e UNIVERSITY OF ULM   (Germany)

Author keywords

Growth factors; Hepatc regeneration; Inflammation; Sepsis

Indexed keywords

EPIDERMAL GROWTH FACTOR; MESSENGER RNA; MITOGENIC AGENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER REGENERATION; PRIORITY JOURNAL; SEPSIS;

EID: 10144243314     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.60.3.382     Document Type: Article

References (46)

1. Nussler, A. K., Billiar, T. R. (1993) Inflammation, immunoregulation and inducible nitric oxide synthase. J. Leukoc. Biol. 54, 171-178.
2. Nussler, A. K., Di Silvio, M., Liu, Z. Z., Geller, D. A., Freeswick, P., Dorko, K., Bartoli, F., Billiar, T. R. (1995) Further characterization and comparison of inducible nitric oxide synthase in mouse, rat and human hepatocytes. Hepatology 21, 1552-1560.
3. Geller, D. A., De Vera, M. A., Russell, D. A., Shapiro, R. A., Nussler, A. K., Simmons, R. L., Billiar, T. R. (1995) A central role for interleukin-1 in the in vivo and in vitro regulation of hepatic nitric oxide synthase. J. Immunol. 155, 4890-4896.
4. Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, J., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., Keefer, L. K. (1991) DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 254, 1001-1003.
5. Lepoivre, M., Chenais, B., Yapo, A., Lemaire, G., Thelander, L., Tenu, J. P. (1990) Alteration of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. J. Biol. Chem. 265, 14143-14149.
6. Billiar, T. R., Curran, R. D., Stuehr, D. J., West, M. A., Bentz, B. G., Simmons, R. L. (1989) An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J. Exp. Med. 169, 1467-1472.
7. Luss, H., Di Silvio, M., Litton, A. L., Molina y Vedia, L, Nussler, A. K., Billiar, T. R. (1994) Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation. Biochem. Biophys. Res. Commun. 204, 635-640.
8. Stadler, J., Billiar, T. R., Curran, R. D., Stuehr, D. J., Ochoa, J. B., Simmons, R. L. (1991) Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am. J. Physiol. 260, C910-C916.
9. Molina y Vedia, L., McDonald, B., Reep, B., Bruene, B., Di Silvio, M., Billiar, T. R., Lapetina, E. G. (1992) Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J. Biol. Chem. 267, 24929-24932.
10. Stadler, J., Trockfeld, J., Schmalix, W. A., Brill, T., Siewert, R., Greim, H., Doehmer, J. (1994) Inhibition of cytochrome P4501A by nitric oxide. Proc. Natl. Acad. Sci. USA 91, 3559-3563.
11. Albina, J. E., Cui, S., Mateo, R. B., Reichner, J. S. (1993) Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150, 5080-5085.
12. Heck, D. E., Laskin, D. L., Gardner, C. R., Laskin, J. D. (1992) Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes: Potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. 267, 21277-21282.
13. Goureau, O., Lepoivre, M., Becquet, F., Courtois, Y. (1993) Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor β in bovine retinal epithelial cells: Inverse correlation with cellular proliferation. Proc. Natl. Acad. Sci. USA 90, 4276-4282.
14. Vodovotz, Y., Bogdan, C., Paik, J., Xie, Q., Nathan, C. (1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor b. J. Exp. Med. 178, 605-613.
15. Asano, K., Chee, C. B. E., Gaston, B., Lilly, C. M., Gerad, C., Drazen, J. M., Stamler, J. S. (1994) Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91, 10089-10093.
16. Michalopoulos, G. K. (1990) Liver regeneration: Molecular mechanisms of growth control. FASEB J. 4, 176-187.
17. G-methylarginine. Anal. Biochem. 57, 310-315.
18. Nussler, A., Di Silvio, M., Billiar, T., Hoffman, R., Geller, D., Selby, R., Madariaga, J., Simmons, R. L. (1992) Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176, 261-264.
19. Dorko, K., Freeswick, P. D., Bartoli, F., Cicalese, L., Bardsley, B. A., Nussler, A. K. (1994) A new technique for isolating and culturing human hepatocytes from whole or split livers unsuitable for transplantation. Cell. Transplant. 3, 387-392.
20. Nussler, A. K., Liu, Z.-Z., Di Silvio, M., Sweetland, M. A., Geller, D. A., Lancaster, J. R., Jr., Billiar, T. R., Freeswick, P. D., Lowenstein, C. L., Simmons, R. L. (1994) Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density. Am. J. Physiol. 266, 394-403.
21. Michalopoulos, G. K., Bowen, W., Nussler, A. K., Becich, M. J., Howard, T. A. (1993) Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen get. J. Cell. Physiol. 156, 443-452.
22. Oberhammer, F., Pavelka, M., Sharrna, S., Tiefenbacher, R., Purchio, T. A., Bursch, W., Schuhe-Hermann, R. (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-bl. Proc. Natl. Acad. Sci. USA 89, 5408-5412.
23. Chomczynski, P., Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
24. Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Di Silvio, M., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H., Billiar, T. R. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA 90, 3491-3495.
25. 15N]nitrate in biological fluids. Anal. Biochem. 126, 131-137.
26. Nussler, A. K., Geller, D. A., Sweetland, M. A., Di Silvio, M., Billiar, T. R., Madariaga, J. B., Simmons, R. L., Lancaster, J. R. (1993) Induction of nitric oxide synthase and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS1. Biochem. Biophys. Res. Commun. 194, 826-835.
27. Luetteke, N. C., Michalopoulos, G. K. (1987) Control of hepatocyte proliferation in vitro. In The Isolated Hepatocyte, New York, Academic Press, 93-117.
28. Tilly, J. L., Billig, H., Kowalski, K. I., Hsueh, A. J. W. (1992) Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol. Endocrinol. 6, 1942-1950.
29. Webber, E. M., FitzGerald, M. J., Brown, P. I., Bartlett, M. H., Fausto, N. (1993) Transforming growth factor-α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-a and hepatocyte growth factor. Hepatology 18, 1422-1431.
30. Shinagawa, T., Yoshioka, K., Kakumu, S., Wakita, T., Ishikawa, T., Itoh, Y., Takayanagi, M. (1991) Apoptosis in cultured rat hepatocytes: The effects of tumour necrosis factor a and interferon γ. J. Pathol. 165, 247-253.
31. Oberhammer, F., Bursch, W., Tiefenbacher, R., Froeschl, G., Pavelka, M., Purchio, T., Schuhe-Hermann, R. (1993) Apoptosis is induced by transforming growth factor-bl within 5 h in regression liver without significant fragmentation of the DNA. Hepatology 18, 1238-1246.
32. Gerschenson, L. E., Rotello, R. J. (1992) Apoptosis: A different type of cell death. FASEB J. 6, 2450-2459.
33. Arends, M. J., Wyllie, A. H. (1991) Apoptosis: Mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32, 223-235.
34. Nathan, C., Xie, Q. W. (1994) Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269, 13725-13728.
35. 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ. J. Immunol. 145, 940-944.
36. BB in vascular smooth muscle cells. Eur. J. Pharmacol. 216, 379-383.
37. 2 inhibits interleukin-1b and tumour necrosis factor-a induction of nitric oxide synthase in rat renal mesangial cells. Biochem. Biophys. Res. Commun. 175, 372-379.
38. Nelson, B. J., Ralph, P., Green, S. J., Nacy, C. A. (1991) Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-bl. J. Immunol. 146, 1849-1857.
39. Junquero, D. C., Scott-Burden, T., Schini, V. B., Vanhoutte, P. M. (1992) Inhibition of cytokine-induced nitric oxide production by transforming growth factor-bl in human smooth muscle cells. J. Physiol. 454, 451-465.
40. Gilbert, R. S., Herechman, H. R. (1993) Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types. Biochem. Biophys. Res. Commun. 195, 380-384.
41. Curran, R. D., Billiar, T. R., Stuehr, D. J., Hofmann, K., Simmons, R. L. (1989) Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. Exp. Med. 170, 1769-1774.
42. Nussler, A., Drapier, J.-C., Renia, L., Pied, S., Miltgen, F., Gentilini, M., Mazier, D. (1991) L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Eur. J. Immunol 21, 227-230.
43. Mellouk, S., Hoffman, S. L., Liu, Z.-Z., de la Vega, P., Billiar, T. R., Nussler, A. K. (1994) Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by interferon-γ and the parasite itself: Enhancement by exogenous tetrahydrobiopterin. Infect. Immun. 62, 4043-4047.
44. Stadler, J., Bergonia, H. A., Di Silvio, M., Sweetland, M. A., Billiar, T. R., Simmons, R. L., Lancaster, J. R., Jr. (1993) Nonheme iron-nitrosyl complex formation in rat hepatocytes: Detection by electron paramagnetic resonance spectroscopy. Arch. Biochem. Biophys. 302, 4-11.
45. Bennett, N. T., Schultz, G. S. (1993) Growth factors and wound healing: Biochemical properties of growth factors and their receptors. Am. J. Surg. 165, 728-737.
46. Circolo, A., Pierce, G. F., Katz, Y., Strunk, R. C. (1990) Anti-inflammatory effects of polypeptide growth factors. J. Biol. Chem. 25, 5066-5071.