Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: Chemosensitivity is regulated by cellular p53

British Journal of Cancer

Volumn 75, Issue 11, 1997, Pages 1559-1566

  Rauth, S ^a,b   Kichina, J ^a   Green, A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Department of Surgical Oncology ^*  (United States)

Author keywords

Differentiation; Genistein; Growth; Metastatic melanoma; P53

Indexed keywords

CELL PROTEIN; GENISTEIN; ISOFLAVONE; MELANIN; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; PROTEIN P53;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE PHASE; CELL DIFFERENTIATION; CELL GROWTH; CHEMOSENSITIVITY; CONTROLLED STUDY; DENDRITE; DNA TRANSFECTION; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031011596     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.268     Document Type: Article

References (41)

1. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M and Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262: 5592-5595
2. Baker SJ, Markowitz S, Fearon ER, Wilson JKV and Vogelstein B (1990) Suppression of human colorectal carcinoma cell growth by wild type p53. Science 249: 912-915
3. Bowen R, Barnes S and Wei H (1993) Antipromotional effect of the soybean isoflavone genistein. Proc Am Assoc Cancer Res 34: 555
4. Brozena S, Frenske NA, Perez IR (1993) Epidemiology of malignant melanoma, world wide incidence and etiologic factors. Semin Surg Oncol 9: 165-167
5. Buckley AR, Buckley DJ, Gout PW, Liang H, Rao Y and Blake M (1993) Inhibition by genistein of prolactin induced Nb2 lymphoma cell mitogenesis. Mol Cell Endocrinol 98: 17-25
6. Cai Q and Wei H (1996) Effect of dietary genistein on antioxidant enzyme activities in Sencar mice. Nutr Cancer 25 (1): 1-7
7. Constantinou A, Kiguchi K and Huberman E (1990) Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res 50: 2618-2624
8. El-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer EW, Kinzler KW and Vogelstein B (1993) WAF1, a potential mediator of p53 suppression. Cell 75: 817-825
9. El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrel PM, Hill DE, Wang Y, Winman KG, Mercer WE, Kastan M, Kohn B, Elledge SJ, Kinzler KW and Vogelstein B (1994) WAF1/C1p1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174
10. Elledge RM, Gray R, Mansour E, Yu Y, Clark GM, Raydin P, Osborne CK, Gilchrist K, Davidson NE, Robert N, Tormey DC and Allred DC (1995) Accumulation of p53 protein as a possible predictor of response to adjuvent chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer. J Natl Cancer Inst 87: 1254-1256
11. Faber KA and Hughes CL Jr (1991) The effect of neonatal exposure to diethylstillbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. Biol Reprod 45: 649-653
12. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311
13. Kastan MB, Zhan Q, El-Deiry WS, Carrier WS, Jacks F, Walsch WV, Plunkett BS, Vogelstein B and Fornace A (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597
14. Kichina J, Green A and Rauth S (1996) Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines. Pigment Cell Res 9: 85-91
15. Kiguchi K, Constantinou AI and Huberman E (1990) Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells. Cancer Commun 2: 271-278
16. Kondo K, Tsuneizumi K, Watanabe T and Oishi M (1991) Induction of in vitro differentiation of mouse embryonal carcinoma (F9) cells by inhibitors of topoisomerases. Cancer Res 51: 5398-5404
17. Lamartiniere CA, Moore JB, Holland MB and Barnes S (1994) Chemoprevention of mammary cancer from neonatal genistein treatment. Proc Am Assoc Cancer Res 35: 3689
18. Limtrakul P, Suttajit M, Semura R, Shimada K and Yamamoto S (1993) Suppressive effect of soybean milk protein on experimentally induced skin tumors in mice. Life Sci 53 (21): 1591-1596
19. Lowe SW, Schmit EM, Smith SW, Osborne BA and Jacks T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849
20. Markovits J, Linassier C, Fosse P, Couprie J, Pierre J, Jacquemin-Sablon A, Saucier J, Le Pecq J and Larsen AK (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 49: 5111-5117
21. Messina M and Barnes S (1991) The role of soy products in reducing risk of cancer. J Natl Cancer Inst 83: 541-545
22. Messina MJ, Persky V, Kenneth KDR, Setchell DR and Barnes S (1994) Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Canter 21: 113-131
23. Nagasawa H (1980) Nutrition and breast cancer: a survey of experimental and epidemiological evidence. IRCS J Med Sci 8: 317-325
24. Noonan KE, Beck TA, Holzmayer JE, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, William CL, Griffith B, Von Hoff D and Roninson IB (1990) Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA 87: 7160-7164
25. Pagliacci MC, Spinozzi F, Migliorati G, Fumi G, Smacchia M, Grignani F, Riccardi C and Nicoletti I (1993) Genistein inhibits tumor cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur J Cancer 29A: 1573-1577
26. Peterson G and Barnes S (1991) Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptor and the multidrug resistance gene. Biochem Biophys Res Commun 179: 661-667
27. Peterson G and Barnes S (1993) Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine phosphorylation. Prostate 22: 335-345
28. Pisha E, Chai H, Lee I, Chagwedra TE, Fransworth NR, Cordell GA, Beecher CWW, Fong HHS, Kinghorn AD, Brown DM, Wani MC, Wall ME, Heiken TJ, Das Gupta TK and Pezzulo JM (1995) Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature Med 1 (10): 1046-1051
29. Powers TP, Shows TB and Davidson RL (1994) Pigment-cell specific genes from fibroblasts are transactivated after chromosomal transfer in to melanoma cells. Mol Cell Biol 14: 1179-1190
30. Rauth S and Davidson RL (1993) Suppression of tyrosinase gene expression by bromodeoxyuridine in Syrian hamster melanoma cells is not due to its incorporation into upstream or coding sequences of the tyrosinase gene. Somat Cell Mol Genet 19: 285-293
31. Rauth S, Hoganson GE and Davidson RL (1990) Bromodeoxyuridine and cyclic-AMP mediated regulation of tyrosinase in Syrian hamster melanoma cells. Somat Cell Mol Genet 16: 285-293
32. Rauth S, Kichina J, Green A, Bratescu L and Das Gupta TK (1994a) Establishment of a human melanoma cell line lacking p53 expression and spontaneously metastasizing in nude mice. Anticancer Res 14: 2457-2464
33. Rauth SJ, Green A, Bratescu L and Das Gupta TK (1994b) Chromosome abnormalities in metastatic melanoma. In Vitro Cell Dev Biol 30A: 79-84
34. Schweigerer L, Christeleit K, Fleischmann G, Adlercreutz H, Wahala K, Hase T, Schwal M, Ludwig R and Fotsis T (1992) Identification in human urine of a natural growth inhibitor for cells derived from solid pediatric tumors. Eur J Clin Invest 22: 260-264
35. Spinozzi F, Pagliacci C, Graziella M, Rasalba M, Grignani F, Riccardi C and Nicoletti I (1994) The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in jurkat T-leukemia cells. Leuk Res 18: 431-439
36. Steele VE, Pereira MA, Sigman CC and Kelloff GJ (1995) Cancer chemoprevention agent development strategies for genistein. J Nutr 125: 713S-716S
37. Traganos F, Ardelt B, Halko N, Bruno S and Darzynkiewicz Z (1992) Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 52: 6200-6208
38. Troll W, Belman S, Wiesner RS and Shellabarger CJ (1979) Protease action in carcinogenesis. In Biological Functions of Proteases, Holzer H and Teshesche H (eds), pp. 165-170. Springer-Verlag: New York
39. Watanabe T, Kondo K and Oishi M (1991) Induction of in vitro differentiation of mouse erythroleukemia cells by genistein, an inhibitor of tyrosine protein kinases. Cancer Res 51: 764-768
40. Wei H, Wei L, Frenkel K, Bowen R and Barnes S (1993) Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutr Cancer 20: 1-12
41. Wei H, Bowen R, Cai Q, Barnes S and Wang Y (1995) Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exp Biol Med 208 (1): 124-130