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85037507930
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The booklet is provided free of charge from Chiron Technologies
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An excellent literature review can be found in Solid-Phase Chemistry Publications. The booklet is provided free of charge from Chiron Technologies, www.chirontechnologies.com.
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Solid-phase Chemistry Publications
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8
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85037494741
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Electronic reviews and links to solid-phase organic reactions can be found at
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Electronic reviews and links to solid-phase organic reactions can be found at www.5z.com/moldiv/.
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0030062528
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Adapted from general methods described by von Geldern, T. W.; Hutchins, C.; Kester, J. A.; Wu-Wong, J. R.; Chiou, W.; Dixon, D. B.; Opgenorth, T. J. J. Med. Chem, 1996, 39, 957-967.
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13
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85037517910
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note
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Alternatively, we have prepared many of the corresponding thiazoles by ring closure with 1.1 equiv Lawesson's reagent, reflux in THF, 4 h.
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14
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0029126779
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Multipins are surface functionalized graft polymers, machine shaped into gears and pins that may be mounted onto a holder. The loading details the total number of active surface sites available for reaction, e.g., a 1.6 μmole gear will theoretically produce 1.6 μmoles of product. Comprehensive details may be found at www.chirontechnologies.com. For an excellent example of parallel synthesis on multipins, see, Bastos, M.; Maeji, N. J.; Abeles, R. H. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6738-6742.
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Maeji, N.J.2
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Albericio, F.5
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17
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0030934020
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Report No. 428
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Many reagents and conditions for deprotection of the O-allyl ether were attempted, based upon complexes of palladium, rhodium, and iridium, the chemistries of which are reviewed by Guibe, F. Tetrahedron 1997, 53 (Report No. 428), 13509-13556.
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23
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85037506014
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note
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Early reactions were conducted on an analogue of 4{3,4} which contained the 3-phenylpropionoyl cap in place of the 3-furanoyl group. Otherwise, the sequence, gears, and loading were identical.
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24
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0042778562
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(a) Alpegiani, M.; Perrone, E.; Franceschi, G. Heterocycles, 1988, 27, 49.
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Jarosinski, M.A.5
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28
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85037512676
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note
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The conversion of alcohol to bromide was also attempted on analogous 5-(hydroxyethyl)oxazole scaffolds. Here, the insertion of an extra methylene between the heterocycle and alcohol had a profound effect on the quality of crude molecules. The bromide was obtained in only 10-20% yield, along with two unidentified major products. Attempts to displace with azide and reduce gave a main material that was tentatively assigned as replacement of hydroxyl by DTT at m/z +138.
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33748644423
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Meinjohanns, E.; Meldal, M.; Jensen, T.; Werdelin, O.; Galli-Stampino, L.; Mouritsen, S.; Block, K. J. Chem. Soc., Perkin Trans. 1 1997, 6, 871-884.
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Jensen, T.3
Werdelin, O.4
Galli-Stampino, L.5
Mouritsen, S.6
Block, K.7
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30
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85037517028
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note
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Unpublished observations from an extensive examination of reaction conditions for the acylation of multipin-bound free Nα-lysine(Boc)-Rink-1.6 μmole gears with sulfonyl chlorides.
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0000595570
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Potential solutions to the problem of parallel quantification of combinatorial libraries are beginning to emerge, e.g., Taylor, E. W.; Qian, M. G.; Dollinger, G. D. Anal. Chem. 1998, 70, 3339-3347.
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Dollinger, G.D.3
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