Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry

Tetrahedron Letters

Volumn 37, Issue 17, 1996, Pages 3019-3022

  Valerio, Robert M ^a,b   Bray, Andrew M ^a   Patsiouras, Heather ^a  

^a Mimotopes Pty Ltd   (Australia)

^b Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ETHER DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; REACTION ANALYSIS; TECHNIQUE;

EID: 0029878622     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00458-3     Document Type: Article

References (21)

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21. 3/DEAD/alcohol/THF (0.15M in each reagent) containing TEA (0.45M) added (0.5 ml/pin). Reactions were carried out in sealed 2 ml centrifuge tubes at 37°C for 4 days after which the pins were removed, washed with DMF and DCM, and then the products cleaved by treatment with 95% TFA/5% water for 90 min. Solvent was removed under a stream of nitrogen and samples dissolved in 60% acetonitrile/water for reverse phase HPLC and ionspray MS analysis.