Insulin-like growth factor-I given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of myelin proteins in experimental autoimmune encephalomyelitis

Life Sciences

Volumn 58, Issue 16, 1996, Pages 1301-1306

  Yao, Da Lin ^a   Liu, Xia ^a   Hudson, Lynn D ^a   Webster, Henry DeF ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Experimental autoimmune encephalomyelitis; Insulin like growth factor I; Multiple sclerosis; Myelin regenration; Oligodendroglia

Indexed keywords

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; MESSENGER RNA; MYELIN BASIC PROTEIN; MYELIN PROTEIN; PROTEOLIPID PROTEIN; SOMATOMEDIN C;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; EXERCISE; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTIPLE SCLEROSIS; MYELINATION; NONHUMAN; OLIGODENDROGLIA; RAT; REGENERATION; SPINAL CORD; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0029935517     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(96)00095-1     Document Type: Article

References (19)

1. F.A. MCMORRIS, T.M. SMITH, S. DESALVO AND R.W. FURLANETTO, Proc. Natl. Acad. Sci. USA 83 822-826 (1986).
2. F.A. MCMORRIS AND M. DUBOIS-DALCQ, J. Neurosci. Res. 21 199-209 (1988).
3. B.A. BARRES, I.K. HART, H.S.R. COLES, J.F. BURNE, J.T. VOYVODIC, W.D. RICHARDSON AND M.C. RAFF, Cell 70 31-46 (1992).
4. B.A. BARRES, R. SCHMID, M. SENDNTER AND M.C. RAFF, Development 118 283-295 (1993).
5. M.J. CARSON, R.R. BEHRINGER, R.L. BRINSTER AND F.A. MCMORRIS, Neuron 10 729-740 (1993).
6. K.D. BECK, L. POWELL-BRAXTON, H.-R. WIDMER, J. VALVERDE AND F. HEFTI, Neuron 14 717-730 (1995).
7. S. KOMOLY, L.D. HUDSON, H.D. WEBSTER AND C.A. BONDY, Proc. Natl. Acad. Sci. USA 89 1894-1898 (1992).
8. X. LIU, D.-L. YAO, C.A. BONDY, M. BRENNER, L.D. HUDSON, J. ZHOU AND H.D. WEBSTER, Mol. Cell. Neurosci. 5 418-430 (1994).
9. D.-L. YAO, N.R. WEST, C.A. BONDY, M. BRENNER, L.D. HUDSON, J. ZHOU, G.H. COLLINS AND H.D. WEBSTER, J. Neurosci. Res. 40 647-659 (1995a).
10. X. LIU, D.-L. YAO AND H.D. WEBSTER, Mult. Scler. 1 2-9 (1995).
11. D.-L. YAO, X. LIU, L.D. HUDSON AND H.D. WEBSTER, Proc. Natl. Acad. Sci. USA 92 6190-6194 (1995b).
12. D.-L. YAO, H.D. WEBSTER, L.D. HUDSON, M. BRENNER, D.-S. LIU, A.I. ESCOBAR AND S. KOMOLY, Ann. Neurol. 35 18-30 (1994).
13. D.B. STONG AND R. RASKIN, Ann. N. Y. Acad. Sci. 692 317-320 (1993).
14. C. BONDY, Ann. Int. Med. 120 593-601 (1994).
15. P.C. CONTRERAS, C. STEFFLER, E. YU, K. CALLISON, D. STONG AND J.L. VAUGHT, J. Pharmacol. Exp. Ther. 274 1443-1449 (1995).
16. R.R. REINHARDT AND C.A. BONDY, Endocrinology 135 1753-1761 (1994).
17. V.F. TAPSON, M. BONI-SCHNETZLER, P.F. PILCH, D.M. CENTER AND J.S. BERMAN, J. Clin. Invest. 82 950-957 (1988).
18. R. CLARK, J. STRASSER, S. MCCABE, K. ROBBINS AND P. JARDIEU, J. Clin. Invest. 92 540-548 (1993).
19. K. ROBBINS, S. MCCABE, T. SCHEINER, J. STRASSER, R.P. CLARK AND P. JARDIEU, Clin. Exp. Immunol. 95 337-342 (1994).