Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat

Pain

Volumn 67, Issue 2-3, 1996, Pages 379-389

  Buritova, Jaroslava ^a,b   Honoré, Prisca ^a   Besson, Jean Marie ^a  

^a PSL RESEARCH UNIVERSITY   (France)

^b INSERM   (France)

Author keywords

c Fos; carrageenan; inflammatory pain; ketoprofen; noxious heat; rat; spinal cord

Indexed keywords

CARRAGEENAN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN C FOS;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD; THERMAL EXPOSURE;

EID: 0030273636     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(96)03138-7     Document Type: Article

References (55)

1. Abbadie, C. and Besson, J.-M., c-fos expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis, Neuroscience, 48 (1992) 985-993.
2. Abbadie, C. and Besson, J.-M., Effects of morphine and naloxone on basal and evoked Fos-like immunoreactivity in lumbar spinal cord neurons of arthritic rats, Pain, 52 (1993) 29-39.
3. Abbadie, C. and Besson, J.-M., Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and fos-like immunoreactivity in rat lumbar spinal cord, Pain, 57 (1994) 45-54.
4. Abbadie, C., Honoré, P., Fournié-Zaluski, M.C., Roques, B.P. and Besson, J.-M., Effects of opioids and non-opioids on c-Fos immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation, Eur. J. Pharmacol., 258 (1994) 215-227.
5. Besson, J.-M. and Chaouch, A., Peripheral and spinal mechanisms of nociception, Physíol. Rev., 67 (1987) 67-186.
6. Buritova, J., Honoré, P., Chapman, V. and Besson, J.-M., Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat, Neurosci. Lett., 188 (1995a) 175-178.
7. Buritova, J., Honoré, P., Chapman, V. and Besson, J.-M., Carrageenan oedema and spinal Fos-LI neurons are reduced by piroxicam in the rat, NeuroReport, 6 (1995b) 1257-1260.
8. Buritova, J., Chapman, V., Honoré, P. and Besson, J.-M., Interactions between NMDA and prostaglandin receptor mediated events in model of inflammatory nociception, Eur. J. Pharmacol., 303 (1996a) 91-100.
9. Buritova, J., Honoré, P., Chapman, V. and Besson, J.-M., Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and spinal c-Fos expression in the rat: synergistic mechanisms, Pain, 64 (1996b) 559-568.
10. Buritova, J., Chapman, V., Honoré, P. and Besson, J.-M., Selective cyclooxygenase-2 inhibition reduces canrageenan oedema and spinal c-Fos expression in the rat, Brain Res., 715 (1996c) 217-220.
11. Cailleteau, J.G., Ketoprofen in dentistry: a pharmacologic review, Oral. Surg., 66 (1988) 620-624.
12. Caldwell, J.R., Germain, B.F., Lourie, S.H., McLaughlin, G.E., Poiley, J.E., Vreede, P.D. and Wilson, C.H., Ketoprofen versus indomethacin in patients with rheumatoid arthritis: a multicenter double blind comparative study, J. Rheumatol., 15 (1988) 1476-1479.
13. Chapman, V., Honoré, P., Buritova, J. and Besson, J.-M., Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat, Neuroscience, 67 (1995a) 731-739.
14. Chapman, V., Honoré, P., Buritova, J. and Besson, J.-M., The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory pain, Br. J. Pharmacol., 116 (1995b) 1628-1634.
15. Cooper, S.A., Review of ketoprofen, J. Clin. Dent., 1 (1988) 1-5.
16. Di Rosa, M., Giroud, J.P. and Willoughby, D.A., Studies of the mediators of the acute inflammatory-response induced in rats in different sites by carrageenin and turpentine, J. Pathol., 104 (1971) 15-29.
17. Dray, A., Inflammatory mediators of pain, Br. J. Anaesth., 75 (1995) 125-131.
18. Ferreira, S.H., Prostanglandins, aspirin-like drugs and analgesia, Nature, 240 (1972) 200-203.
19. Flower, R.J. and Vane, J.R., Inhibition of prostaglandin biosynthesis, Biochem. Pharmacol., 23 (1974) 1439-1450.
20. Flower, R., Gryglewski, R., Herbaczynska-Cedro, K. and Vane, J.R., Effects of anti-inflammatory drugs on prostaglandin biosynthesis, Nature, 238 (1972) 104-106.
21. Fu, J.Y., Masferrer, J.L., Seibert, K., Raz, A. and Needleman, P., The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes, J. Bíol. Chem., 265 (1990) 16737-16740.
22. Hargreaves, K., Dubner, R., Brown, F., Flores, C. and Joris, J., A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia, Pain, 32 (1988) 77-88.
23. Honoré, P., Buritova, J. and Besson, J.-M., Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin, Eur. J. Pharmacol., 272 (1995a) 249-259.
24. Honoré, P., Buritova, J. and Besson, J.-M., Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation, Pain, 63 (1995c) 365-375.
25. Honoré, P., Chapman, V., Buritova, J. and Besson, J.-M., When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat? Brain Res., 705 (1995d) 91-96.
26. Honoré, P., Buritova, J., Chapman, V. and Besson, J.-M., Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat, Br. J. Pharmacol., 118 (1996) 671-680.
27. Hsu, S., Raine, L. and Fanger, H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures, J. Histochem. Cytochem., 29 (1981) 577-580.
28. Hughes, P. and Dragunow, M., Induction of immediate-early genes and the control of neurotransmitter-regulated expression within the nervous system, Pharmacol. Rev., 47 (1995) 133-178.
29. Iadarola, M.J., Brady, L.S., Draisci, G. and Dubner, R., Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding, Pain, 35 (1988) 313-326.
30. Insel, P.A., Analgesic-antipyretics and anti-inflammatory agents: drugs employed in treatment of rheumatoid arthritis and gout. In: A. Goodman-Gilman, T.W. Rall, A.S. Nies and P. Taylor (Eds.), The Pharmacological Basis of Therapeutics, Vol. 8, McGraw-Hill, Singapore, 1991, pp. 638-681.
31. Jamali, F. and Brocks, D.R., Clinical pharmacokinetics of ketoprofen and its enantiomers, Clin. Pharmacokinet, 19 (1990) 197-217.
32. Joris, J., Costello, A., Dubner, R. and Hargreaves, K., Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia, Pain, 43 (1990) 95-103.
33. Jurna, I., Spohrer, B. and Bock, R., Intrathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord, Pain, 49 (1992) 249-256.
34. Kayser, V. and Guilbaud, G., Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat, Pain, 28 (1987) 99-107.
35. Lauritsen, K., Laursen, L.S., Kjeldsen, J., Bukhave, K. and Rask-Madsen, J., Inhibition of eicosanoid synthesis and potential therapeutic benefits of 'dual pathway inhibition', Pharmacol. Toxicol., 75 (Suppl. 11) (1994) 9-13.
36. Lloret, S. and Moreno, J.J., In vitro and in vivo effects of the anti-inflammatory peptides, antiflammins, Biochem. Pharmacol., 44 (1992)1437-1441.
37. Malmberg, A.B. and Yaksh, T.L., Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat, J. Pharmacol. Exp. Ther., 263 (1992) 136-146.
38. Malmberg, A.B. and Yaksh, T.L., Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat, Neurosci. Lett., 173 (1994a) 193-196.
39. Malmberg, A.B. and Yaksh, T.L., Antinociception produced by spinal delivery of S and R enantiomers of flurbiprofen in the formalin test in rats, Eur. J. Pharmacol., 256 (1994b) 205-209.
40. Masferrer, J.L., Zweifel, B.S., Manning, P.T., Hauser, S.D., Leahy, K.M., Smith, W.G., Isakson, P.C. and Seibert, K., Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic, Proc. Natl. Acad. Sci. USA, 91 (1994) 3228-3232.
41. Menétrey, D., de Pommery, J., Baimbridge, K.G. and Thomasset, M., Calbindin-D28K (CaBP28k)-like immunoreactivity in ascending projections. I. Trigeminal nucleus caudalis and dorsal vagal complex projections, Eur. J. Neurosci., 4 (1992) 61-69.
42. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., Flower, R.J. and Vane, J.R., Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase, Proc. Natl. Acad. Sci. USA, 90 (1993) 11693-11697.
43. Molander, C. and Grant, G., Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn: a study by transganglionic transport of horseradish peroxidase in the rat, Neuroscience, 19 (1986) 297-312.
44. Noguchi, K., Kowalski, K., Traub, R., Solodkin, A., Iadarola, M.J. and Ruda, M.A., Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons, Mol. Brain Res., 10 (1991) 227-233.
45. Noguchi, K., Dubner, R. and Ruda, M.A., Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins, Neuroscience, 46 (1992) 561-570.
46. Sigurdsson, G.H., Youssef, H.A.F. and Owunnwanne, A., Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock, Res, Exp. Med., 194 (1994) 287-295.
47. Vane, J.R., Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs, Nature New Biol., 231 (1971) 232-235.
48. Veys, E.M., 20 years' experience with ketoprofen, Scand. J. Rheumatol., 20 (Suppl. 90) (1991) 3-44.
49. Willer, J.C., De Broucker, T., Bussel, B., Roby-Brami, A. and Harrewyn, J.M., Central analgesic effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study, Pain, 38 (1989) 1-7.
50. Williams, S., Evan, G.I. and Hunt, S.P., Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat, Neuroscience, 36 (1990) 73-81.
51. Willis, W.D. and Coggeshall, R.E., Sensory Mechanisms of the Spinal Cord, Plenum Press, New York, 1991, pp. 79-151.
52. Winter, C.A., Risley, E.A. and Nuss, G.W., Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med., 111 (1962) 544-547.
53. Wisden, W., Errington, M.L., Williams, S., Dunnett, S.B., Waters, C., Hitchcock, S., Evan, G., Bliss, T.V.P. and Hunt, S.P., Differential expression of immediate early genes in the hippocampus and spinal cord, Neuron, 4 (1990) 603-614.
54. Zieglgänsberger, W. and Tölle, T.R., The pharmacology of pain signalling, Curr. Opin. Neurobiol., 3 (1993) 611-618.
55. Zimmermann, M., Ethical guidelines for investigations of experimental pain in conscious animals, Pain, 16 (1983) 109-110.