Soluble CD8 attenuates cytotoxic T cell responses against replication- defective adenovirus affording transprotection of transgenes in vivo

Journal of Immunology

Volumn 165, Issue 3, 2000, Pages 1470-1478

  Peng, YuFeng ^a   Falck Pedersen, Erik ^a   Elkon, Keith B ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; GENE DELETION; GENE TARGETING; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENE; VIRUS REPLICATION;

EID: 0034254715     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.3.1470     Document Type: Article

References (49)

1. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 4:478.
2. Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
3. + T-helper and a T-killer cell. Nature 393:474.
4. Yang, Y., H. C. Ertl, and J. M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433.
5. Yang, Y., Z. Xiang, H. C. Ertl, and J. M. Wilson. 1995. Upregulation of class I major histocompatibility complex antigens by interferon γ is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257.
6. Turner, J. M., M. H. Brodsky, B. A. Irving, S. D. Levin, R. M. Perlmutter, and D. R. Littman. 1990. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60:755.
7. Anel, A., A. M. O'Rourke, A. M. Kleinfeld, and M. F. Mescher. 1996. T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: activation of p56lck by CD8 binding to class I protein. Eur. J. Immunol. 6:2310.
8. Kersh, E. N., A. S. Shaw, and P. M. Allen. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572.
9. Veillette, A., M. A. Bookman, E. M. Horak, and J. B. Bolen. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55:301.
10. Zamoyska, R., P. Derham, S. D. Gorman, P. von Hoegen, J. B. Bolen, A. Veillette, and J. R. Parnes. 1989. Inability of CD8 α′ polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature 342:278.
11. Parnes, J. R. 1989. Molecular biology and function of CD4 and CD8. Adv. Immunol. 44:265.
12. + T lymphocytes. Eur. J. Immunol. 23:2834.
13. Araham, N., M. C. Miceli, J. R. Parnes, and A. Veillette. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature 350:62.
14. Peng, Y., J. Trevejo, J. Zhou, M. W. Marino, R. G. Crystal, E. Falck-Pederson, and K. B. Elkon. 1999. Inhibition of tumour necrosis factor α by an adenovirus-encoded soluble fusion protein extends transgene expression in the liver and lung. J. Virol. 73:5098.
15. Sewell, A. K., U. C. Gerth, D. A. Price, M. A. Purbhoo, J. M. Boulter, G. F. Gao, J. I. Bell, R. E. Phillips, and B. K. Jakobsen. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nat. Med 5:399.
16. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
17. Elkon, K. B., C. C. Liu, J. G. Gall, J. Trevejo, M. W. Marino, K. A. Abrahamsen, L. J. Old, R. G. Crystal, X. Song, J. L. Zhou, and E. Falck-Pedersen. 1997. TNF-α plays a central role in immune mediated clearance of adenoviral vectors. Proc. Natl. Acad. Sci. USA 94:9814.
18. Drappa, J., N. Brot, and K. B. Elkon. 1993. The Fas protein is expressed at high levels on double positive thymocytes and activated mature T cells in normal but not MRL/lpr mice. Proc. Natl. Acad. Sci. USA 90:10340.
19. Watanabe, H., K. Ohtsuka, M. Kimura, Y. Ikarashi, K. Ohmori, A. Kusumi, T. Ohteki, S. Seki, and T. Abo. 1992. Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods 146:145.
20. Bot, A., S. Bot, and C. A. Bona. 1998. Protective role of γ interferon during the recall response to influenza virus. J. Virol. 72:6637.
21. Suzuki, M., R. Singh, M. A. Moore, W. R. Song, and R. G. Crystal. 1998. Similarity of strain- and route-dependent murine responses to an adenovirus vector using the homologous thrombopoietin cDNA as the reporter genes. Hum. Gene Ther. 20:1223.
22. Krajcsi, P., T. Dimitrov, T. W. Hermiston, A. E. Tollefson, T. S. Ranheim, S. B. Vande Pol, A. H. Stephenson, and W. S. M. Wold. 1996. The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-α induced release of arachidonic acid. J. Virol. 70:4904.
23. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
24. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenolype T cells. J. Exp. Med. 179:1127.
25. + T cells during an acute virus infection. Immunity 8:167.
26. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177.
27. Koniaras, C., S. R. Bennett, F. R. Carbone, W. R. Heath, and A. Lew. 1997. Peptide-induced deletion of CD8 T cells ir vivo occurs via apoptosis in situ. Int. Immunol. 9:1601.
28. b. Immunity 9:519.
29. Salter, R. D., R. J. Benjamin, P. K. Wesley. S. E. Buxton, T. P. Garrett, C. Clayberger, A. M. Krensky, A. M. Norment, D. R. Littman, and P. Parham. 1990. A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2. Nature 345:41.
30. Potter, T. A., T. V. Rajan, R. F. Dick, Jr., and J. A. Bluestone. 1989. Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 337:73.
31. Connolly, J. M., T. H. Hansen, A. L. Ingold, and T. A. Potter. 1990. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class Iα3 domain: CD8 and the T-cell receptor recognize the same class I molecule. Proc. Natl. Acad. Sci. USA 87:2137.
32. Aldrich, C. J., R. E. Hammer, S. Jones-Youngblood, U. Koszinowski, L. Hood, I. Stroynowski, and J. Forman. 1991. Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules. Nature 352:718.
33. Wyer, J. R., B. E. Willcox, G. F. Gao, U. C. Gerth, S. J. Davis, J. I. Bell, P. A. van der Merwe, and B. K. Jakobsen. 1999. T cell receptor and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics. Immunity 10:219.
34. Norment, A. M., R. D. Salter, P. Parham, V. H. Engelhard, and D. R. Littman. 1988. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature 336:79.
35. Garcia, K. C., C. A. Scott, A. Brunmark, F. R. Carbone, P. A. Peterson, I. A. Wilson, and L. Teyton. 1996. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 384:577.
36. Thome, M., V. Germain, J. P. DiSanto, and O. Acuto. 1996 The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/ CD3/ζ complex. Eur. J. Immunol. 26:2093.
37. Delon, J., C. Gregoire, B. Malissen, S. Darche, F. Lemaitre, P. Kourilsky, J. P. Abastado, and A. Trautmann. 1998. CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. Immunity 9:467.
38. Purbhoo, M. A., A. K. Sewell, P. Klenerman, P. J. Goulder, K. L. Hilyard, J. I. Bell, B. K. Jakobsen, and R. E. Phillips. 1998. Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc. Natl. Acad. Sci. USA 95:4527.
39. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407.
40. Choksi, S., B. A. Jameson, and R. Korngold. 1998. A structure-based approach to designing synthetic CD8α peptides that can inhibit cytotoxic T-lymphocyte responses. Nat. Med. 4:309.
41. Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2:151.
42. Morral, N., W. O'Neal, H. Zhou, C. Langston, and A. Beaudet. 1997. Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum. Gene Ther. 8:1275.
43. Muzzin, P., R. C. Eisensmith, K. C. Copeland, and S. L. Woo. 1996. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc. Natl. Acad. Sci. USA 93:14804.
44. + CTLs in vivo. J. Immunol. 155:2564.
45. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
46. Zuany-Amorim, C., C. Ruffie, S. Haile, B. B. Vargaftig, P. Pereira, and M. Pretolani. 1998. Requirement for γδ T cells in allergic airway inflammation. Science 280:1265.
47. Korsgren, M., C. G. Persson, F. Sundler, T. Bjerke, T. Hansson, B. J. Chambers, S. Hong, L. Van Kaer, H. G. Ljunggren, and O. Korsgren. 1999. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J. Exp. Med. 189:553.
48. Tisch, R., and H. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell 85:291.
49. Delovitch, T. L., and B. Singh. 1997. The non-obese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.