A Leu262Pro mutation in the integrin β3 subunit results in an α(IIb)- β3 complex that binds fibrin but not fibrinogen

Blood

Volumn 96, Issue 1, 2000, Pages 161-169

  Ward, Christopher M ^b   Kestin, Anita S ^b   Newman, Peter J ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; INTEGRIN; LEUCINE; PROLINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BLOOD CLOT RETRACTION; CASE REPORT; CELL STRAIN COS1; FEMALE; FIBRIN CLOT; FLOW CYTOMETRY; GLANZMANN DISEASE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MISSENSE MUTATION; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; STOP CODON; THROMBOCYTE AGGREGATION;

EID: 0034234624     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.1.161.013k50_161_169     Document Type: Article

References (51)

1. ++-dependent complexes of platelet membrane glycoproteins IIb and IIIa in solution as determined by crossed immunoelectrophoresis. Blood. 1981;58:268-278.
2. Bennett JS, Vilaire G, Cines DB. Identification of the fibrinogen receptor on human platelets by photoaffinity labeling. J Biol Chem. 1982;257: 8049-8054.
3. Pytela R, Pierschbacher MD, Ginsberg MH, Plow EF, Ruoslahti E. Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp-specific adhesion receptors. Science. 1986;231: 1559-1562.
4. Newman PJ, Poncz M. Inherited disorders of platelets. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. III. New York, NY: McGraw-Hill; 1995:3335-3366.
5. French D, Coller BS. Hematologically important mutations: Glanzmann thrombasthenia. Blood Cells Mol Dis. 1997;23:39-51.
6. 3 (GPIIb-IIIa) receptor function. J Biol Chem. 1994;269:20913-20919.
7. 3 subunit. J Biol Chem. 1996;271:21978-21984.
8. 3 complex. J Clin Invest. 1997;100:2392-2403.
9. Doolittle RF. The molecular biology of fibrin. In: Stamatoyannopoulos G, Nienhuis AW, Majerus PW, Varmus H, eds. Molecular Basis of Blood Diseases. Philadelphia, PA: WB Saunders; 1994: 701-719.
10. Lam SC-T, Plow EF, Smith MA, et al. Evidence that Arginyl-Glycyl-Aspartate peptides and fibrinogen γ chain peptides share a common binding site on platelets. J Biol Chem. 1987;262:947-950.
11. Farrell DH, Thiagarajan P. Binding of recombinant fibrinogen mutants to platelets. J Biol Chem. 1994;269:226-231.
12. 3. EMBO J. 1996;15: 5760-5771.
13. Rooney MM, Parise LV, Lord ST. Dissecting clot retraction and platelet aggregation. J Biol Chem. 1996;271:8553-8555.
14. 3. J Biol Chem. 1996;271:30544-30547.
15. D'Souza SE, Ginsberg MH, Burke TA, Lam SC-T, Plow EF. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science. 1988;242:1-93.
16. 3 subunit: cation displacement is involved in ligand binding. Cell. 1994;79:659-667.
17. Charo IF, Nannizzi L, Phillips DR, Hsu MA, Scarborough RM. Inhibition of fibrinogen binding to GPIIb-IIIa by a GPIIIa peptide. J Biol Chem. 1991;266:1415-1421.
18. D'Souza SE, Ginsberg MH, Burke TA, Plow EF. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its α subunit. J Biol Chem. 1990;265:3440-3446.
19. Kamata T, Irie A, Tokuhira M, Takada Y. Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3). J Biol Chem. 1996;271:18610-18615.
20. Hantgan RR, Taylor RG, Lewis JC. Platelets interact with fibrin only after activation. Blood. 1985;65:1299-1311.
21. Niewiarowski S. Interaction of fibrin with various cells. Thromb Diath Haemorrh. 1973;56:51-61.
22. Fournier DJ, Kabral A, Castaldi PA, Berndt MC. A variant of Glanzmann's thrombasthenia characterized by abnormal glycoprotein IIb/IIIa complex formation. Thromb Haemost. 1989;62:977-983.
23. 3 subunit: differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J Biol Chem. 1995;270:9550-9557.
24. 3 integrin in mediating fibrin gel retraction. J Biol Chem. 1995;270:1785-1790.
25. 3. Blood. 1995;86:2606-2615.
26. McEver RP, Bennett EM, Martin MN. Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem. 1983;258:5269-5275.
27. Newman PJ, Allen RW, Kahn RA, Kunicki TJ. Quantitation of membrane glycoprotein IIIa on intact human platelets using the mAb, AP-3. Blood. 1985;65:227-232.
28. Pidard D, Montgomery RR, Bennett JS, Kunicki TJ. Interaction of AP-2, a mAb specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J Biol Chem. 1983;258:12582-12586.
29. Cheresh DA. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A. 1987;84:6471-6475.
30. Calvete JJ, Henschen A, Gonzalez-Rodriguez J. Assignment of the disulphide binds in human platelet GPIIIa: a disulphide pattern for the β-subunits of the integrin family. Biochem J. 1991;274: 63-71.
31. 3 integrin complex. J Biol Chem. 1994;269:4450-4457.
32. O'Toole TE, Loftus JC, Plow EF, Glass AA, Harper JR, Ginsberg MH. Efficient surface expression of platelet GPIIb-IIIa requires both subunits. Blood. 1989;74:14-18.
33. 3 complex that retains partial function in a novel form of Type II Glanzmann thrombasthenia. Thromb Haemost. 1998;80:42-48.
34. Skogen B, Wang R, McFarland JG, Newman PJ. A dinucleotide deletion in exon 4 of the PIA2 form of glycoprotein IIIa: implications for the correlation of serologic versus genotypic analysis of human platelet alloantigens. Blood. 1996;88:3831-3836.
35. Newman PJ, Seligsohn U, Lyman S, Coller BS. The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel. Proc Natl Acad Sci U S A. 1991;88:3160-3164.
36. Rosenberg N, Yatuv R, Orion Y, et al. Glanzmann thrombasthenia caused by an 11.2-kb deletion in the glycoprotein IIIa (beta3) is a second mutation in Iraqi Jews that stemmed from a distinct founder. Blood. 1997;89:3654-3662.
37. Wilcox DA, Paddock CM, Lyman S, Gill JC, Newman PJ. Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. J Clin Invest. 1995;95:1553-1560.
38. Vinciguerra C, Khelif A, Alemany M, et al. A nonsense mutation in the GPIIb heavy chain (Ser870→stop) impairs platelet GPIIb-IIIa expression. Br J Haematol. 1996;95:399-407.
39. v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. J Biol Chem. 1990; 265:5983-5941.
40. Gartner TK, Ogilvie ML. Peptides and monoclonal antibodies which bind to platelet glycoproteins IIb and/or IIIa inhibit clot retraction. Thromb Res. 1988;49:43-53.
41. Cheresh DA, Berliner SA, Vicente V, Ruggeri ZM. Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cell. 1989;58:944-953.
42. Smith RA, Mosesson MW, Rooney MM, Lord ST, Daniels AU, Gartner TK. The role of putative fibrinogen Aα-, Bβ- and γA-chain integrin binding sites in endothelial cell-mediated clot retraction. J Biol Chem. 1997;272:22080-22085.
43. Calvete JJ, Mann K, Alvarez MV, Lopez MM, Gonzalez-Rodriguez J. Proteolytic dissection of the isolated platelet fibrinogen receptor, integrin GPIIb/IIIa. Biochem J. 1992;282:523-532.
44. Calvete JJ, Arias J, Alvarez MV, Lopez MM, Henschen A, Gonzalez-Rodriguez J. Further studies on the topography of the N-terminal region of human platelet glycoprotein IIIa. Biochem J. 1991; 274:457-463.
45. Cook JJ, Tyrbulec M, Lascz EC, Khan S, Niewiarowski S. Binding of glycoprotein IIIa-derived peptide 217-231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex. Biochim Biophys Acta. 1992; 1119:312-321.
46. 3 (GPIIb-IIIa) and inhibit ligand binding. J Biol Chem. 1993;268:6870-6873.
47. 3 complex and with fibrinogen Aα-chain. Thromb Res. 1997;85:115-126.
48. 5 subunits contain a metal ion-dependent adhesion site-like motif but lack an I domain. J Biol Chem. 1997;272:14236-14243.
49. 3 provides a ligand recognition and binding domain for the γ-chain of fibrinogen that is independent of platelet activation. Blood. 1996;87:592-601.
50. Gartner TK, Amrani DL, Derrick JM, Kirschbaum NE, Matsueda GR, Taylor DB. Characterization of adhesion of "resting" and stimulated platelets to fibrinogen and its fragments. Thromb Res. 1993; 71:47-60.
51. Mosesson MW. Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coagul Fibrinolysis. 1997;8:257-267.