Sequence 274-368 in the β3-subunit of the integrin αIIbβ3 provides a ligand recognition and binding domain for the γ-chain of fibrinogen that is independent of platelet activation

Blood

Volumn 87, Issue 2, 1996, Pages 592-601

  Alemany, Mònica ^c   Concord, Evelyne ^c   Garin, Jérome ^c   Vinçon, Mathilde ^c   Giles, A ^c   Marguerie, Gérard ^a   Gulino, Danielle ^b  

^a Department of Heart and Stroke   (Canada)

^b INSERM   (France)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; INTEGRIN; LIGAND; MONOCLONAL ANTIBODY; PROTEIN SUBUNIT;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GLANZMANN DISEASE; HEMOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ALPROSTADIL; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BINDING SITES; EGTAZIC ACID; FIBRINOGEN; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; THROMBIN;

EID: 0030048888     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.2.592.bloodjournal872592     Document Type: Article

References (35)

1. Hynes RO: Integrins: A family of cell surface receptors. Cell 48:549, 1987
2. Coller BS: Interaction of normal thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: Defective platelet-fibrinogen interaction in thrombasthenia. Blood 55:169, 1980
3. Savage B, Ruggeri ZM: Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J Biol Chem 266:11227, 1991
4. Nurden AT: Glycoprotein defects responsible for abnormal platelet function in inherited platelet disorders, in George JN, Nurden AT, Phillips DR (eds): Platelet Membrane Glycoproteins. New York, NY, Plenum 1985, p 357
5. Andrieux A, Hudry-Clergeon G, Ryckewaert J-J, Chapel A, Ginsberg MH, Plow EF, Marguerie G: Amino acid sequences in fibrinogen mediating its interaction with its platelet receptor. GPIIbI-IIa. J Biol Chem 264:9258, 1989
6. Lam CT, Plow EF, Smith MA, Andrieux A, Ryckewaert JJ, Marguerie G. Evidence that arginyl-glycinyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets. J Biol Chem 262:947, 1987
7. Kirschbaum NE, Mosesson MW, Amrani DL: Characterization of the gamma chain platelet binding site on fibrinogen fragment D Blood 79:2643, 1992
8. Bennett JS, Shattil SJ, Power JW, Kent-Gartner T: Interaction of fibrinogen with its platelet receptor Differential effects of a and gamma chain fibrinogen peptides on the glycoprotein IIBIIIA complex. J Biol Chem 263:12948, 1988
9. Weisel JW, Nagaswami C, Vilaire G, Bennett JS: Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy J Biol Chem 267:16637, 1992
10. Farrell DH, Thiagarajan P, Chung DW, Davie EW: Role of fibrinogen α and gamma chain sites in platelet agregation. Proc Natl Acad Sci USA 89:10729, 1992
11. D'Souza SE, Ginsberg MH, Lam SC-T, Plow EF: Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets. J Biol Chem 263:3943, 1988
12. D'Souza SE, Ginsberg MH, Burke TA, Lam SC-T, Plow EF. Localization of an arg-gly-asp recognition site within an integrin adhesion receptor. Science 242:91, 1988
13. Charo IF, Nannizzi L, Phillips DR, Hsu MA, Scarborough RM: Inhibition of fibrinogen binding to GPIIbIIIa by a GPIIIa peptide. J Biol Chem 266:1415, 1991
14. Lasz EC, McLane MA, Trybulec M, Kowalska MA, Khan S, Budzynski AZ, Niewriarowski S: β3 integrin derived peptide 217-230 inhibits fibrinogen binding and platelet aggregation: Significance of RGD sequences and fibrinogen Aα-chain Biochem Biophys Res Commun 190:118, 1993
15. Steiner B, Trzeciak A, Pfenninger G, Kouns WC: Peptides derived from a sequence within β3 integrin bind to platelet αIIb β3 (GPIIb-IIIa) and inhibit ligand binding. J Biol Chem 268:6870, 1993
16. D'Souza SE. Ginsberg MH, Burke TA, Plow EF: The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its α subunit J Biol Chem 265:3440, 1990
17. D'Souza SE, Ginsberg MH, Matsueda GR, Plow EF: A discrete sequence in a platelet integrin is involved in ligand recognition. Nature 350:66, 1991
18. Gulino D, Boudignon C, Zhang L, Concord E, Rabiet MJ, Marguerie G: Calcium binding properties of the platelet GPIIb ligand interacting domain. J Biol Chem 267:1001, 1992
19. Taylor DB, Gartner TK: A peptide corresponding to GPIIbα 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIbIIIa, inhibits the adhesion of platelets to at least four adhesive ligands. J Biol Chem 267:11729, 1992
20. Loftus JC, O'Toole TE, Plow EF, Glass A, Frelinger AL III, Ginsberg MH: A β 3 integrin mutation abolishes ligand binding and alters divalent cation dependent conformation. Science 249:915, 1990
21. Bajt ML, Ginsberg MH, Frelinger AL III, Berndt MC, Loftus JC: A spontaneous mutation of integrin αIIb β3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. J Biol Chem 267:3789, 1992
22. Kieffer N, Fitzgerald LA, Wolf D, Cheresh DA, Phillips DR: Adhesive properties of the β3 integrins: Comparison of GPIIbIIIb and the vitronectin receptor individually expressed in human melanoma cells. J Cell Biol 113:451, 1991
23. Marguerie GA, Plow EF, Edgington TS: Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem 254:5357, 1979
24. Fitzgerald LA, Leung B, Phillips DR: A method for purifying the platelet membrane glycoprotein IIb-IIIa complex. Anal Biochem 151:169, 1985
25. Gulino D, Ryckewaert J-J, Andrieux A, Rabiet M-J, Marguerie G: Identification of a monoclonal antibody against platelet GPIIb that interacts with a calcium binding site and induces aggregation. J Biol Chem 265.9575, 1990
26. Andrieux A, Rabiet MJ, Chapel A, Concord E, Marguerie G: A highly conserved sequence of the Arg-Gly-Asp binding domain of the integrin β3 subunit is sensitive to stimulation. J Biol Chem 266:14202, 1991
27. Mc Conahey PJ, Dixon FJ: Radioiodination of proteins by the use of the chloramine T method. Methods Enzymol 70:210, 1980
28. Vivaudou MB, Arnoult C, Villaz M: Skeletal muscle ATP-sensitive K+ channels recorded from sarcolemmal bleds of split fibers: ATP inhibition is reduced by magnesium and ADP. J Membrane Biol 122:165, 1991
29. Ginsberg MH, Taylor L, Painter RG: The mechanism of thrombin-induced platelet factor 4-secretion. Blood 55:661, 1980
30. Calvete JJ, Henschen A, Gonzales-Rodriguez J: Assignment of disulfide bonds in human platelet GPIIIa. A disulfide pattern for the β subunits of the integrin family. Biochem J 274:63, 1991
31. Duperray A, Berthier R, Chagnon E, Ryckewaert JJ, Ginsberg MH, Plow E, Marguerie G: Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes. J Cell Chem 104:1665, 1987
32. Niiya K, Hodson E, Bader R, Byers-Ward V, Kosiol JA, Plow EF, Ruggeri ZM: Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation. Blood 70:475, 1987
33. Farrell DH, Thiagarajan P: Binding of recombinant fibrinogen mutants to platelets. J Biol Chem 269.226, 1994
34. Chen F, Coller BS, French DL: Homozygous mutation of platelet glycoprotein IIIa (β3) Cys374-Tyr in a chinese patient with Glanzmann thrombasthenia. Blood 82:163a, 1993 (abstr, suppl 1)
35. Yasuda T, Gold HK, Fallon JT, Leinbach RC, Guerrero JL, Scudder LE, Kanke M, Shealy D, Ross MJ, Collen D, Coller BS: Monoclonal antibody against the platelet glycoprotein (GP) IIb/IIIa receptor prevents coronary artery reocclusion after reperfusion with recombinant tissue-type plasminogen activator in dogs. J Clin Invest 81:1284, 1988