Nociceptin/orphanin FQ and its receptor: A potential target for drug discovery

Trends in Pharmacological Sciences

Volumn 21, Issue 7, 2000, Pages 233-234

  Bertorelli, Rosalia ^b   Calò, Girolamo ^c   Ongini, Ennio ^c   Regoli, Domenico ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b Schering Plough Research Institute   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

NOCICEPTIN; NOCICEPTIN RECEPTOR; OPIATE PEPTIDE; OPIATE RECEPTOR; 1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ALCOHOL; MORPHINE; NEUROPEPTIDE; NOCICEPTIN DERIVATIVE; RECEPTOR BLOCKING AGENT; RO 646198; UNCLASSIFIED DRUG;

ADDICTION; ANIMAL; AUTONOMIC NERVE; CONFERENCE PAPER; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HUMAN; PAIN; ANIMAL MODEL; ANXIETY; AUTONOMIC NERVOUS SYSTEM; CHRONIC PAIN; DRUG ABUSE; KNOCKOUT MOUSE; MICTURITION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR BINDING; SPINAL CORD;

ANIMALS; AUTONOMIC PATHWAYS; BEHAVIOR, ADDICTIVE; HUMANS; OPIOID PEPTIDES; PAIN; RECEPTORS, OPIOID;

EID: 0034218754     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01492-9     Document Type: Conference Paper

References (6)

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2. Reinscheid R.K.et al. Orphanin FQ. a neuropeptide that activates an opioid-like G protein-coupled receptor Science. 270:1995;792-794.
3. Calò G.et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br. J. Pharmacol. 129:2000;1261-1283.
4. 2 new selective nociceptin receptor antagonist. Br. J. Pharmacol. 129:2000;1183-1193.
5. Ozaki S.et al. A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397. Eur. J. Pharmacol. 387:2000;R17-R18.
6. Jenck F.et al. A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1. anxiolytic profile in the rat Proc. Natl. Acad. Sci. U. S. A. 97:2000;4938-4943.