No "End of history" for photolyases

Science

Volumn 272, Issue 5258, 1996, Pages 48-49

  Sancar, Aziz ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOBUTANE DERIVATIVE; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; FOLIC ACID; PYRIMIDINE DIMER; QUERCETIN;

CHROMATOPHORE; DNA DAMAGE; DNA REPAIR; ELECTRON TRANSPORT; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR CLONING; PHOTOREACTIVATION; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; SHORT SURVEY; ULTRAVIOLET RADIATION;

ANIMALS; CLONING, MOLECULAR; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; DNA; DNA DAMAGE; DNA REPAIR; DROSOPHILA; DROSOPHILA PROTEINS; EYE PROTEINS; FLAVOPROTEINS; HUMANS; PHOTORECEPTORS, INVERTEBRATE; PLANT PROTEINS; PYRIMIDINE DIMERS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 0029874444     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5258.48     Document Type: Review

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21. On 8 July 1990, B. A. Horwitz from the Israel Institute of Technology wrote me a letter stating that ' it seems possible that cryptochrome has flavin and pterin chromophores " which "raises the possibility that cryptochromes might share homology with DNA photolyase" and offered to collaborate with our group to search for the cryptochrome genes by using the E. coli photolyase gene as a probe. I sent him the photolyase clone but did not take him up on his offer to collaborate. I thought it was a far-out idea.