N-substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as 92 antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3342-3355

  Birch, Alan M ^a   Bradley, Paul A ^a   Gill, Julie C ^a   Kerrigan, Frank ^a   Needham, Pat L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 [4 (1,4 BENZODIOXAN 2 YLMETHYLAMINO)BUTYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR; HALOPERIDOL; MAZAPERTINE; METHYLAMINE; MUSCARINIC RECEPTOR; NEUROLEPTIC AGENT; OLANZAPINE; OSEMOZOTAN; REPINOTAN; RISPERIDONE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PSYCHIATRIC TREATMENT; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CATALEPSY; DIOXANES; DOPAMINE ANTAGONISTS; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MICE; MOTOR ACTIVITY; PIPERIDINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT PROTEINS; SEROTONIN AGONISTS; STEREOISOMERISM; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0033606948     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9910122     Document Type: Article

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