IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells

Journal of Immunology

Volumn 164, Issue 7, 2000, Pages 3500-3505

  Skov, Søren ^a,b   Bonyhadi, Mark ^a   ØDum, Niels ^b   Ledbetter, Jeffrey A ^a  

^a Xcyte Therapies Inc   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 5;

ARTICLE; CELL MATURATION; CELLULAR IMMUNITY; COMPLEMENT ACTIVATION; COMPLEX FORMATION; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

EID: 0034176099     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.7.3500     Document Type: Article

References (28)

1. Mackey, M. F., R. J. Barth, and R. J. Noelle. 1998. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J. Leukocyte Biol. 63:418.
2. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
3. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
4. Mackey, M. F., J. R. Gunn, C. Maliszewsky, H. Kikutani, R. J. Noelle, and R. J. Barth. 1998. Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J. Immunol. 161:2094.
5. Thomsen, A. R., A. Nansen, J. P. Christensen, S. O. Andreasen, and O. Marker. 1998. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J. Immunol. 161:4583
6. + T-helper and a T-killer cell. Nature 393: 474.
7. Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
8. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393:478.
9. Sotomayor, E. M., I. Borrello, E. Tubb, F. M. Rattis, H. Bien, Z. Lu, S. Fein, S. Schoenberger, and H. I. Levitsky. 1999. Conversion of tumor-specific CD4 T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat. Med 5:780.
10. Diehl, L., A. T. Boer, S. P. Schoenberger, E. I. H. Voort, T. N. M. Schumacher, C. J. Melief, R. Offringa, and R. E. Toes. 1999. CD40 activation in vivo overcomes peptide-induced peripheral cylotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat. Med 5:774.
11. + T cells from HIV-1-infected donors after CD3/CD28 costimulation. J. Hematother. 7:437.
12. Fuleihan, R., N. Ramesh, A. Horner, D. Ahem, P. J. Belshaw, D. G. Alberg, I. Stamenkovic, W. Harmon, and R. S. Geha. 1994. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J. Clin. Invest. 93:1315.
13. + T cells. J. Immunol. 151:2497.
14. Schubert, L. A., G. King, R. Q. Cron, D. B. Lewis, A. Aruffo, and D. Hollenbaugh. 1995. The human gp39 promoter: two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J. Biol. Chem. 270:29624.
15. Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82.
16. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680.
17. Wulting, C., and M. M. Davis. 1998. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282:2266.
18. Johnson-Leger, C., J. Christensen, and G. G. Klaus. 1998, CD28 co-stimulation stabilizes the expression of the CD40 ligand on T cells. Int. Immunol. 10:1083.
19. Peng, X., J. E. Remade, A. Kasran, D. Huylebroeck, and J. L. Ceuppens. 1998. IL-12 up-regulates CD40 ligand (CD154) expression on human T cells. J. Immunol. 160:1166.
20. Yellin, M. J., K. Sippel, G. Inghirami, L. R. Covey, J. J. Lee, J. Sinning, E. A. Clark, L. Chess, and S. Lederman, 1994. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/ CD40-L: potential role in regulating helper effector function. J. Immunol. 152:598.
21. van Kooten, C., C. Gaillard, J. P. Galizzi, P. Hermann, F. Fossiez, J. Banchereau, and D. Blanchard. 1994. B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24:787.
22. June, C. H., J. A. Ledhetter, M. M. Gille-ipie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol 7:4472.
23. Waldmann, T., Y. Tagaya, and R. Bamford. 1998. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 16:205.
24. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
25. MacDonald, K. P., Y. Nishioka, P. E. Lipsky, and R. Thomas. 1997. Functional CD40 ligund is expressed by T cells in rheumatoid arthritis. J. Clin. Invest. 100: 2404.
26. McInnes, I. B., and F. Y. Liew. 1998. Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis. Immunol. Today 19:75.
27. Farrington, M., L. S. Grosmaire, S. Nonoyama, S. H. Fischer, D. Hollenbaugh, J. A. Ledbetler, R. J. Noelle, A. Aruffo, and H. D. Ochs. 1994. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc. Natl. Acad. Sci. USA 91:1099.
28. Bowen, F., J. Haluskey, and H. Quill. 1995. Altered CD40 ligand induction in tolerant T lymphocytes. Eur. J. Immunol. 25:2830.