Classic Kaposi sarcoma: Epidemiology and risk factors

Cancer

Volumn 88, Issue 3, 2000, Pages 500-517

  Iscovich, Jose ^a,f   Boffetta, Paolo ^b   Franceschi, Silvia ^c   Azizi, Esther ^d   Sarid, Ronit ^e  

^a Selikoff Center for Environmental Health and Human Development   (Israel)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d TEL AVIV UNIVERSITY   (Israel)

^e BAR ILAN UNIVERSITY   (Israel)

^f International Fertility Institute   (Israel)

Author keywords

Classic Kaposi sarcoma; Epidemiology; Human herpesvirus 8 (HHVS); Kaposi sarcoma; Kaposi sarcoma associated herpesvirus (KSHV); Rate of incidence

Indexed keywords

CANCER EPIDEMIOLOGY; CANCER RISK; DNA VIRUS; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; KAPOSI SARCOMA; PRIORITY JOURNAL; REVIEW; VIRUS INFECTION;

ADOLESCENT; ADULT; AFRICA; AGE FACTORS; AGED; AGED, 80 AND OVER; AMERICAS; CHILD; COCARCINOGENESIS; ETHNIC GROUPS; EUROPE; FEMALE; HERPESVIRUS 8, HUMAN; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PREVALENCE; RISK FACTORS; SARCOMA, KAPOSI; SEX FACTORS;

EID: 0034142168     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(20000201)88:3<500::AID-CNCR3>3.0.CO;2-9     Document Type: Review

References (222)

1. Kaposi M. Idiopathisches multiples Pigmentsarkom der Haut. Arch f Dermatol u Syph 1872;3:265-73.
2. Köbner H. Zur Kenntnis der allgemeinen Sarcomatose under der Hausarcome im besonderen. Arch f Dermatol u Syph 1869;1:369-81.
3. Dorffel J. Histogenesis of multiple idiopathic hemorrhagic sarcoma of Kaposi. [Review on the subject on 356 cases up to 1932 and 16 cases personally]. Arch Dermatol Syph 1932; 26:608-34.
4. Beral V. Epidemiology of Kaposi's sarcoma. Cancer Surv 1991;10:5-22.
5. Laor Y, Schwartz RA. Epidemiologic aspects of American Kaposi's sarcoma. J Surg Oncol 1979;12:299-303.
6. Biggar RJ, Horm J, Fraumeni JFJ, Greene MH, Goedert JJ. Incidence of Kaposi's sarcoma and mycosis fungoides in the United States including Puerto Rico, 1973-81. J Natl Cancer Inst 1984;73:89-94.
7. Ross RK, Casagrande JT, Dworsky RL, Levine A, Mack T. Kaposi's sarcoma in Los Angeles, California. J Natl Cancer Inst 1985;75:1011-5.
8. Oettle AG. Geographical and racial differences in the frequency of Kaposi's sarcoma as evidence of environmental or genetic causes. Monograph No. 2. Acta Unio Int Contra Cancrum 1962;18:330-63.
9. Davies JNP, Elmes S, Hutt MS. Cancer in an African community, 1897-1956. BMJ 1964;1:259-64.
10. Hutt MS, Burkitt D. Geographical distribution of cancer in East Africa: a new clinicopathological approach. BMJ 1965; 5464:719-22.
11. Slavin G, Cameron HM, Singh H. Kaposi's sarcoma in mainland Tanzania: a report of 117 cases. Br J Cancer 1969;23: 349-57.
12. Taylor JF, Smith PG, Bull D, Pike MC. Kaposi's sarcoma in Uganda: geographic and ethnic distribution. Br J Cancer 1972;26:483-97.
13. Wabinga HR, Parkin DM, Wabwire-Mangen F, Mugerwa JW. Cancer in Kampala, Uganda, in 1989-91: changes in incidence in the era of AIDS. Int J Cancer 1993;54:26-36.
14. Ziegler JL, Katongole-Mbidde E. Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer 1996;65:200-3.
15. Siegel JH, Janis R, Alper JC, Schutte H, Robbins L, Blaufox MD. Disseminated visceral Kaposi's sarcoma. Appearance after human renal homograft operation. JAMA 1969;207: 1493-6.
16. Haim S, Shafrir A, Better OS, Robinson E, Chaimowitz C, Erlik D. Kaposi's sarcoma in association with immunosuppressive therapy. Report of two cases. Isr J Med Sci 1972;8: 1993-7.
17. Hardy MA, Goldfarb P, Levine S, Dattner A, Muggia FM, Levitt S, et al. De novo Kaposi's sarcoma in renal transplantation. Case report and brief review. Cancer 1976;38:144-8.
18. Harwood AR, Osoba D, Hofstader SL, Goldstein MB, Cardella CJ, Holecek MJ, et al. Kaposi's sarcoma in recipients of renal transplants. Am J Med 1979;67:759-65.
19. Kinlen LJ. Immunosuppressive therapy and cancer. Cancer Sun 1982;1:565-83.
20. Penn I. Secondary neoplasms as a consequence of transplantation and cancer therapy. Cancer Detect Prev 1988;12: 39-57.
21. Biggar RJ. Cancer in acquired immunodeficiency syndrome: an epidemiological assessment. Semin Oncol 1990;17:251-60.
22. Friedman-Kien AE, Saltzman BR, Cao YZ, Nestor MS, Mirabile M, Li JJ, et al. Kaposi's sarcoma in HIV-negative homosexual men. Lancet 1990;335:168-9.
23. Beral V, Peterman TA, Berkelman RL, Jaffe HW. Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 1990;335:123-8.
24. Cockerell CJ. Histopathological features of Kaposi's sarcoma in HIV infected individuals. Cancer Surv 1991;10:73-89.
25. Taylor JF, Templeton AC, Vogel CL, Ziegler JL, Kyalwazi SK. Kaposi's sarcoma in Uganda: a clinico-pathological study. Int J Cancer 1971;8:122-35.
26. Kyalwazi SK. Kaposi's sarcoma; clinical features, experience in Uganda. In: Olweny CLM, Hutt MS, Owor R, editors. Kaposi's sarcoma. Basel: S. Karger, 1981:59-67.
27. Peterman TA, Jaffe HW, Friedman-Kien AE, Weiss RA. The aetiology of Kaposi's sarcoma. Cancer Surv 1991;10:23-37.
28. Cottoni F, Montesu MA. Kaposi's sarcoma classification: a problem not yet defined. Int J Dermatol 1996;35:480-3.
29. Schwartz RA. Kaposi's sarcoma: advances and perspectives. J Am Acad Dermatol 1996;34:804-14.
30. Friedman-Kien AE, Saltzman BR. Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi's sarcoma. J Am Acad Dermatol 1990;22:1237-50.
31. Templeton AC, Hutt MS. Distribution of tumours in Uganda. Recent Results Cancer Res 1973;41:1-22.
32. Tappero JW, Conant MA, Wolfe SF, Berger TG. Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol 1993;28:371-95.
33. Lee MC, Gehweiler JAJ. Kaposi's sarcoma in bone: a case report with unusual radiographic findings and an abnormal radioisotope scan. Rev Interam Radiol 1976;1:37-41.
34. Dayan AD, Lewis PD. Origin of Kaposi's sarcoma from the reticulo-endothelial system. Nature 1967;213:889-90.
35. Weiss RA. The conundrum of Kaposi's sarcoma. Eur J Cancer 1990;26:657-9.
36. Roth WK, Brandstetter H, Sturzl M. Cellular and molecular features of HIV-associated Kaposi's sarcoma. AIDS 1992;6: 895-913.
37. Zhang YM, Bachmann S, Hemmer C, van Luzen J, von Stemm A, Kern P, et al. Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. Am J Pathol 1994;144:51-9.
38. Beckstead JH, Wood GS, Fletcher V. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Am J Pathol 1985;119:294-300.
39. Jones RR, Spaull J, Spry C, Jones EW. Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS). J Clin Pathol 1986;39:742-9.
40. Rappersberger K, Wolff K, Stingl G. Kaposi's sarcoma. In: Fitzpatric TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF., editors. Dermatology in general medicine. New York: McGraw Hill, Inc., 1993:1244-56.
41. Costa J, Rabson AS. Generalised Kaposi's sarcoma is not a neoplasm. Lancet 1983;1:58.
42. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human immunodeficiency viruses and human T-cell lymphotropic viruses. Lyon, France, June 1-18, 1996. IARC Monogr Eval Carcinog Risks Hum 1996;67: 1-424.
43. Grulich AE, Beral V, Swerdlow AJ. Kaposi's sarcoma in England and Wales before the AIDS epidemic. Br J Cancer 1992;66:1135-7.
44. Dieballa G. Uber einen mit Lymphoytise einhergehenden Fall von Sarcoma multiplex cutis. Wien Klin Wochenschr 1897;10:523-5.
45. Berhardt R. Weitere mittheilungen uber sarcoma idiopathicum multiplex pigmentosum cutis. [Cited references over 30 CKS, through the period 1890-1902]. Arch f Dermatol u Syph 1902;62:237-62.
46. Mierzecki H. Sarcoma idiopathicum multiplex Kaposi. Arch Dermatol Syph 1932;26:577-84.
47. Greco NV. Elementos clinico-etiologicos de un caso de enfermedad (Sarcomatosis) de Kaposi. Sem Med 1936;2:1761-8.
48. Greco NV, Bigatti A, Ponce de Leon S, Capurro J. Un segundo caso familiar de enfermedad (Sarcomatosis) de Kaposi, con el hongo especifico el Cryptococcus haematicon digestivo. Sem Med 1938;45:989-1000.
49. Choisser RM, Ramsey EM. Angioreticuloendothelioma (Kaposis disease) of heart. Am J Pathol 1939;15:155-78.
50. Hansson CJ. Karposi's sarcoma: clinical and radiotherapeutic studies on twenty-three patients. Acta Radiol 1940;21: 457-70.
51. Azulay RD. Doenca de Kaposi, sarcoma idiopathicum multiplex pigmentosum Kaposi (1872). Grafica Milone: Rio de Janeiro 1949.
52. Mussini-Montpellier J. L'Angio reticulo-endothelio-sarcomatose de Kaposi en Afrique du Nord. Bull Alger Carcinol 1950;3:203-10.
53. McCarthy WD, Pack GT. Malignant blood vessel tumores. A report of 56 cases of angiosarcoma and Kaposi's sarcoma. Surg Gynecol Obstet 1950;91:465-82.
54. Moertel CG, Hagedorn AB. Leukaemia or lymphoma and co-existent primary malignant lesions. Blood 1957;12:788-803.
55. Ronchese F, Kern AB. Kaposi's sarcoma (Angioreticulomatosis). Postgrad Med 1953;14:101-11.
56. Tedeschi CG. Some considerations concerning the nature of the so-called sarcoma of Kaposi. AMA Arch Pathol 1958;66: 656-87.
57. Ronchese F. Kaposi's sarcoma. An overlooked essay of 1882. AMA Arch Dermatol 1958;77:542-54.
58. Cox FH, Helwig EB. Kaposi's sarcoma. Cancer 1959;12:289-98.
59. Bertarccini G. Reticulosarcoma inserto su precedente tipica sarcomatosi di Kaposi. Dermatologica 1959;10:161-2.
60. Rothman S. Some clinical aspects of Kaposi's sarcoma in the European and North American populations. Acta Unio Int Contra Cancrum 1962;72:364-71.
61. Donnelly WJ. Clinico-pathologic conference: Hodgkin's disease and Kaposi's sarcoma. Postgrad Med 1963;33:301-6.
62. Reynolds WA, Winkelmann RK, Soule EH. Kaposi's sarcoma: a clinicopathologic study with particular reference to its relationship to the reticuloendothelial system. Medicine (Baltimore) 1965;44:419-43.
63. Marril FG, Sayag J, Hadida E. L'acro-sarcomatose de Kaposi en Algerie. Med Trop (Mars) 1973;33:471-81.
64. Berg JW. The incidence of multiple primary cancers. I. Development of further cancers in patients with lymphomas, leukemias, and myeloma. J Natl Cancer Inst 1967;38:741-52.
65. Gilbert TT, Evjy JT, Edelstein L. Hodgkin's disease associated with Kaposi's sarcoma and malignant melanoma. Case report of multiple primary malignancies. Cancer 1971;28: 293-9.
66. Dobozy A, Husz S, Hunyadi J, Berko G, Simon N. Immune deficiencies and Kaposi's sarcoma. Lancet 1973;2:625.
67. Manusow D, Weinerman BH. Subsequent neoplasia in chronic lymphocytic leukemia. JAMA 1975;232:267-9.
68. Giraldo G, Beth E, Kourilsky FM, Henle W, Henle G, Mike V, et al. Antibody patterns to herpesviruses in Kaposi's sarcoma: serological association of European Kaposi's sarcoma with cytomegalovirus. Int J Cancer 1975;15:839-48.
69. Chadli A, Rethers L, Landreat A, Habanec B. La phsionomie du cancer en Tunisie: etude de 7,959 cancers primitifs. Arch Inst Pasteur Tunis 1976;4:317-423.
70. Safai B, Mike V, Giraldo G, Beth E, Good RA. Association of Kaposi's sarcoma with second primary malignancies: possible etiopathogenic implications. Cancer 1980;45:1472-9.
71. DiGiovanna JJ, Safai B. Kaposi's sarcoma. Retrospective study of 90 cases with particular emphasis on the familial occurrence, ethnic background and prevalence of other diseases. Am J Med 1981;71:779-83.
72. Ulbright TM, Santa CD. Kaposi's sarcoma: relationship with hematologic, lymphoid, and thymic neoplasia. Cancer 1981; 47:963-73.
73. Hutt MS. Kaposi's sarcoma. Br Med Bull 1984;40:355-8.
74. Gafa L, Gafa R, Dardanoni L. II sarcoma di Kaposi a Raguse e in Sicilia. In: IX Reunion du Groupe pour l'epidemiologie et l'enregistrement du cancer dans les pays de langue latine (IARC Internal Report). Lyon: International Agency for Research on Cancer, 1984.
75. Kaloterakis A, Stratigos J, Trichopoulos D, Karabinis A, Elemenoglou S. Mediterranean Kaposi's sarcoma: preliminary communication about 131 cases. Bull Soc Pathol Exot 1984; 77:570-1.
76. Dictor M, Attewell R. Epidemiology of Kaposi's sarcoma in Sweden prior to the acquired immunodeficiency syndrome. Int J Cancer 1988;42:346-51.
77. Garcia A, Olivella F, Valderrama S, Rodriguez G. Kaposi's sarcoma in Colombia. Cancer 1989;64:2393-8.
78. Geddes M, Franceschi S, Barchielli A, Falcini F, Carli S, Cocconi G, et al. Kaposi's sarcoma in Italy before and after the AIDS epidemic. Br J Cancer 1994;69:333-6.
79. Kaldor JM, Coates M, Vettom L, Taylor R. Epidemiological characteristics of Kaposi's sarcoma prior to the AIDS epidemic. Br J Cancer 1994;70:674-6.
80. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994;266:1865-9.
81. Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 1995;332:1181-5.
82. Ambroziak JA, Blackbourn DJ, Herndier BG, Glogau RG, Gullet JH, McDonald AR, et al. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 1995;268:582-3.
83. Boshoff C, Schulz TF, Kennedy MM, Graham AK, Fisher C, Thomas A, et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1995;1:1274-8.
84. Schalling M, Ekman M, Kaaya EE, Linde A, Biberfeld P. A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat Med 1995;1:707-8.
85. Huang YQ, Li JJ, Kaplan MH, Poiesz B, Katabira F, Zhang WC, et al. Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma. Lancet 1995;345:759-61.
86. Dupin N, Grandadam M, Calvez V, Gorin I, Aubin JR, Havard S, et al. Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma. Lancet 1995;345:761-2.
87. Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, et al. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med 1996;335:233-41.
88. Noel JC, Hermans P, Andre J, Fayt I, Simonart Th, Verhest A, et al. Herpesvirus-like DNA sequences and Kaposi's sarcoma: relationship with epidemiology, clinical spectrum, and histologic features. Cancer 1996;77:2132-6.
89. Hjalgrim H, Melbye M, Lecker S, Frisch M, Thomsen HK, Larsen SO. Epidemiology of classic Kaposi's sarcoma in Denmark between 1970 and 1992. Cancer 1996;77:1373-8.
90. Hjalgrim H, Melbye M, Pukkala E, Langmark F, Frisch M, Dictor M, et al. Epidemiology of Kaposi's sarcoma in the Nordic countries before the AIDS epidemic. Br J Cancer 1996;74:1499-502.
91. Cottoni F, De Marco R, Montesu MA. Classical Kaposi's sarcoma in north-east Sardinia: an overview from 1977 to 1991. Br J Cancer 1996;73:1132-3.
92. Touloumi G, Kaklamanis L, Potouridou I, Katsika-Hatziolou E, Stratigos J, Mueller N, et al. The epidemiologic profile of Kaposi's sarcoma in Greece prior to and during the AIDS era. Int J Cancer 1997;70:538-41.
93. Hjalgrim H, Tulinius H, Dalberg J, Hardarson S, Frisch M, Melbye M. High incidence of classical Kaposi's sarcoma in Iceland and the Faroe Islands. Br J Cancer 1998;77:1190-3.
94. Iscovich J, Boffetta P, Brennan P. Classic Kaposi's sarcoma in Arabs living in Israel, 1970-1993: a population-based incidence study. Int J Cancer 1998;77:319-21.
95. Iscovich J, Boffetta P, Winkelmann R, Brennan P, Azizi E. Classic Kaposi's sarcoma in Jews living in Israel, 1961-1989: a population-based incidence study. AIDS 1998;12:2067-72.
96. Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J. Cancer incidence in five continents. IARC Scientific Pub. No. 143. Lyon: International Agency for Research on Cancer, 1997.
97. Qunibi W, Akhtar M, Sheth K, Ginn HF, Al-Furayh O, De Vol EB, et al. Kaposi's sarcoma: the most common tumor after renal transplantation in Saudi Arabia. Am J Med 1988;84: 225-32.
98. Trattner A, Hodak E, David M, Sandbank M. The appearance of Kaposi sarcoma during corticosteroid therapy. Cancer 1993;72:1779-83.
99. Montagnino G, Bencini PL, Tarantino A, Caputo R, Ponticelli C. Clinical features and course of Kaposi's sarcoma in kidney transplant patients: report of 13 cases. Am J Nephrol 1994;14:121-6.
100. al-Sulaiman MH, al-Khader AA. Kaposi's sarcoma in renal transplant recipients. Transplant Sci 1994;4:46-60.
101. Martensson J, Henrikson H. Immuno-hemolytic anemia in Kaposi's sarcoma with visceral involvement only. Acta Med Scand 1954;150:175-88.
102. Bendsoe N, Dictor M, Blomberg J, Agren S, Merk K. Increased incidence of Kaposi sarcoma in Sweden before the AIDS epidemic. Eur J Cancer 1990;26:699-702.
103. Kinlen LJ. Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer 1995;71:1-5.
104. Rothman S. Remarks on sex, age and racial distribution of Kaposi's sarcoma and on possible pathogenetic factors. Acta Unio Int Contra Cancrum 1962;18:326-9.
105. Dutz W, Stout AP. Kaposi's sarcoma in infants and children. [Review on the subject of over 1,200 cases up to 1958]. Cancer 1960;13:684-94.
106. Grossman CJ. Regulation of the immune system by sex steroids. Endocr Rev 1984;5:435-55.
107. Araneo BA, Dowell T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells. Blood 1991;78:688-99.
108. Lehmann D, Siebold K, Emmons LR, Muller H. Androgens inhibit proliferation of human peripheral blood lymphocytes in vitro. Clin Immunol Immunopathol 1988;46:122-8.
109. Christeff N, Winter C, Gharakhanian S, Thobie N, Wirbel E, Costagliola D, et al. Differences in androgens of HIV positive patients with and without Kaposi sarcoma. J Clin Pathol 1995;48:513-8.
110. Geddes M, Franceschi S, Balzi D, Arniani S, Gafa L, Zanetti R. Birthplace and classic Kaposi's sarcoma in Italy. Associazione Italiana Registri Tumori. J Natl Cancer Inst 1995;87: 1015-7.
111. Warner TF, O'Loughlin S. Kaposi's sarcoma: a byproduct of tumour rejection. Lancet 1975;2:687-9.
112. Filipovich AH, Spector BD, Kersey J. Immunodeficiency in humans as a risk factor in the development of malignancy. Prev Med 1980;9:252-9.
113. Piette WW. The incidence of second malignancies in subsets of Kaposi's sarcoma. J Am Acad Dermatol 1987;16: 855-61.
114. Dalgleish AG. Kaposi's sarcoma. Br J Cancer 1991;64:3-6.
115. Moertel CG. Multiple primary malignant neoplasms, their incidence and significance. In: Recent results in cancer research. New York: Springer-Verlag, 1966:34-47.
116. Biggar RJ, Curtis RE, Cote TR, Rabkin CS, Melbye M. Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome. Am J Epidemiol 1994; 139:362-8.
117. Hjalgrim H, Frisch M, Pukkala E, Tulinius H, Ekbom A, Dictor M, et al. Risk of second cancers in classical Kaposi's sarcoma. Int J Cancer 1997;73:840-3.
118. Franceschi S, Arniani S, Balzi D, Geddes M. Survival of classic Kaposi's sarcoma and risk of second cancer. Br J Cancer 1996;74:1812-4.
119. Iscovich J, Boffetta P, Brennan P. Classic Kaposi's sarcoma as a first primary neoplasm. Int J Cancer 1999;80:173-7.
120. Iscovich J, Boffetta P, Winkelmann R. Classic Kaposi's sarcoma as a second primary neoplasm. Int J Cancer 1999;80: 178-82.
121. Templeton AC. Studies in Kaposi's sarcoma. Postmortem findings and disease patterns in women. Cancer 1972;30: 854-67.
122. Thijs A. L'Angiosarcomatose de Kaposi au Congo Belge et au Ruanda-Urundi. Ann Soc Belg Med Trop 1957;37:295-307.
123. Wahman A, Melnick SL, Rhame FS, Potter JD. The epidemiology of classic, African, and immunosuppressed Kaposi's sarcoma. Epidemiol Rev 1991;13:178-99.
124. Bassett MT, Chokunonga E, Mauchaza B, Levy L, Ferlay J, Parkin DM. Cancer in the African population of Harare, Zimbabwe, 1990-1992. Int J Cancer 1995;63:29-36.
125. Newton R, Ngilimana PJ, Grulich A, Beral V, Sindikubwabo B, Nganyira A, et al. Cancer in Rwanda. Int J Cancer 1996; 66:75-81.
126. Kestens L, Melbye M, Biggar RJ, Stevens WJ, Piot P, De Muynck A, et al. Endemic African Kaposi's sarcoma is not associated with immunodeficiency. Int J Cancer 1985;36:49-54.
127. Gange RW, Jones EW. Kaposi's sarcoma and immunosuppressive therapy: an appraisal. Clin Exp Dermatol 1978:3: 135-46.
128. Klepp O, Dahl O, Stenwig JT. Association of Kaposi's sarcoma and prior immunosuppressive therapy: a 5-year material of Kaposi's sarcoma in Norway. Cancer 1978;42:2626-30.
129. Penn I. Kaposi's sarcoma in transplant recipients. Transplantation 1997;64:669-73.
130. McGinn JT, Rica JJ, Currin JF. Kaposi's sarcoma following allergic angitis. Ann Intern Med 1955;42:921-7.
131. Gill PS, Loureiro C, Bernstein-Singer M, Rarick MU, Sattler F, Levine AM. Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1989;110:937-40.
132. Shmueli D, Shapira Z, Yussim A, Nakache R, Ram Z, Shaharabani E. The incidence of Kaposi sarcoma in renal transplant patients and its relation to immunosuppression. Transplant Proc 1989;21:3209-10.
133. Qunibi W, Al-Furayh O, Almeshari K, Lin SF, Sun R, Heston L, et al. Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia. Transplantation 1998;65:583-5.
134. Ecder ST, Sever MS, Yildiz A, Turkmen A, Kayacan SM, Kilicaslan I, et al. Kaposi's sarcoma after renal transplantation in Turkey. Clin Transplant 1998;12:472-5.
135. Farge D. Kaposi's sarcoma in organ transplant recipients. The Collaborative Transplantation Research Group of Ile de France. Eur J Med 1993;2:339-43.
136. Birkeland SA, Storm HH, Lamm LU, Barlow L, Blohme I, Forsberg B, et al. Cancer risk after renal transplantation in the Nordic countries, 1964-1986. Int J Cancer 1995;60: 183-9.
137. Sheil AG. Cancer in renal allograft recipients in Australia and New Zealand. Transplant Proc 1977;9:1133-8.
138. Sheil AG. Skin cancer in renal transplant recipients. Transplant Sci 1994;4:42-5.
139. Hoshida Y, Tsukuma H, Yasunaga Y, Xu N, Fujita MQ, Satoh T, et al. Cancer risk after renal transplantation in Japan. Int J Cancer 1997;71:517-20.
140. Drut R, Drut RM. EBV-associated Kaposi's sarcoma in a pediatric renal transplant recipient. Pediatr Pathol 1994;14: 863-72.
141. Fournet JC, Peuchmaur M, Eckart P, Gagnadoux MF, Stephan JL, Hubert P, et al. Multicentric Kaposi's sarcoma in a 5-year-old human immunodeficiency virus-negative renal allograft recipient. Hum Pathol 1992;23:956-60.
142. 4+ cell levels. The Multicenter AIDS Cohort Study Group. J Infect Dis 1994;170:775-81.
143. Schlesinger M, Chu FN, Badamchian M, Jiang JD, Roboz JP, Goldstein AL, et al. A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals. Clin Immunol Immunopathol 1994;73: 252-60.
144. Biggar RJ, Rabkin CS. The epidemiology of AIDS - related neoplasms. Hematol Oncol Clin North Am 1996;10:997-1010.
145. Beral V, Newton R. Overview of the epidemiology of immunodeficiency-associated cancers. J Natl Cancer Inst Monogr 1998;(23)1-6.
146. Nakamura S, Salahuddin SZ, Biberfeld P, Ensoli B, Markham PD, Wong-Staal F, et al. Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells. Science 1988;242:426-30.
147. Samaniego F, Markham PD, Gallo RC, Ensoli B. Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J Immunol 1995;154:3582-92.
148. Cornali E, Zietz C, Benelli R, Weninger W, Marsiello L, Breier G, et al. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma. Am J Pathol 1996;149:1851-69.
149. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
150. Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, et al. AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 1989;243:223-6.
151. Karp JE, Pluda JM, Yarchoan R. AIDS-related Kaposi's sarcoma. A template for the translation of molecular pathogenesis into targeted therapeutic approaches. Hematol Oncol Clin North Am 1996;10:1031-49.
152. Samaniego F, Markham PD, Gendelman R, Watanabe Y, Kao V, Kowalski K, et al. Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development. Am J Pathol 1998;152:1433-43.
153. Yamamoto T, Osaki T, Yoneda K, Ueta E. Immunological investigation of adult patients with primary herpes simplex virus-1 infection. J Oral Pathol Med 1993;22:263-7.
154. Moore PS, Chang Y. Kaposi's sarcoma (KS), KS-associated herpesvirus, and the criteria for causality in the age of molecular biology. Am J Epidemiol 1998;147:217-21.
155. Moore PS, Gao SJ, Dominguez G, Cesarman E, Lungu O, Knowles DM, et al. Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae. J Virol 1996;70: 549-58.
156. Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 1996;93:14862-7.
157. Neipel F, Albrecht JC, Fleckenstein B. Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J Virol 1997;71:4187-92.
158. Levy JA. A new human herpesvirus: KSHV or HHV8? Lancet 1995;346:786.
159. Roizman B. New viral footprints in Kaposi's sarcoma. N Engl J Med 1995;332:1227-8.
160. Boshoff C, Whitby D, Hatziioannou T, Fisher C, van der Walt J, Hatzakis A, et al. Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet 1995;345:1043-4.
161. Proceedings of the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8. Lyon, France, June 17-24 1997. IARC Monogr Eval Carcinog Risks Hum 1997;70:1-492.
162. Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, et al. Detection of Kaposi sarcoma associated herpesvirus in peripheral hlood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 1995;346:799-802.
163. Rose TM, Strand KB, Schultz ER, Schaefer G, Rankin GW Jr., Thouless ME, et al. Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol 1997;71:4138-44.
164. Desrosiers RC, Sasseville VG, Czajak SC, Zhang X, Mansfield KG, Kaur A, et al. A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. J Virol 1997;71:9764-9.
165. Pisani P, Parkin DM, Munoz N, Ferlay J. Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epidemiol Biomarkers Prev 1997;6:387-400.
166. Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. Proc Natl Acad Sci USA 1995;92:5258-65.
167. Fredericks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev 1996;9:18-33.
168. Morris JD, Eddleston AL, Crook T. Viral infection and cancer. Lancet 1995;346:754-8.
169. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332:1186-91.
170. Gaidano G, Gloghini A, Gattei V, Rossi MF, Cilia AM, Gordeas C, et al. Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood 1997;90:4894-900.
171. Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 1995;86:2708-14.
172. Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996;88:645-56.
173. Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995;86:1276-80.
174. Arvanitakis L, Mesri EA, Nador RG, Said JW, Asch AS, Knowles DM, et al. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood 1996;88:2648-54.
175. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, et al. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 1996;2:342-6.
176. Said JW, Chien K, Tasaka T, Koeffler HP. Ultrastructural characterization of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (CMV). J Pathol 1997;182:273-81.
177. + cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 1998;91:1671-9.
178. Lebbe C, Pellet C, Tatoud R, Agbalika F, Dosquet P, Desgrez JP, et al. Absence of human herpesvirus 8 sequences in prostate specimens. AIDS 1997;11:270.
179. Lebbe C, Pellet C, Flageul B, Sastre X, Avril MF, Bonvalet D, et al. Sequences of human herpesvirus 8 are not detected in various non-Kaposi sarcoma vascular lesions. Arch Dermatol 1997;133:919-20.
180. Flamand L, Zeman RA, Bryant JL, Lunardi-Iskandar Y, Gallo RC. Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:194-7.
181. Davis MA, Sturzl MA, Blasig C, Schreier A, Guo HG, Reitz M, et al. Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. J Natl Cancer Inst 1997; 89:1868-74.
182. Renne R, Blackbourn D, Whitby D, Levy J, Ganem D. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 1998;72:5182-8.
183. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996;2:918-24.
184. Simpson GR, Schulz TF, Whitby D, Cook PM, Boshoff C, Rainbow L, et al. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996;348:1133-8.
185. Gao SJ, Alsina M, Deng JH, Harrison CR, Montalvo EA, Leach CT, et al. Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 1998;178:846-9.
186. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998; 338:948-54.
187. Olsen SJ, Moore PS. Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) and the etiology of KS. In: Freidman HMP, Bendinelli M, editors. Herpesviruses and immunity. New York: Plenum Publishing, 1999:115-470.
188. Mayama S, Cuevas LE, Sheldon J, Omar OH, Smith DH, Okong P, et al. Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 1998;77:817-20.
189. Rezza G, Lennette ET, Giuliani M, Pezzotti P, Caprilli F, Monini P, et al. Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections. Int J Cancer 1998;77:361-5.
190. Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, et al. Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group. J Infect Dis 1998;178:304-9.
191. Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, et al. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 1996;2:925-8.
192. Kedes DH, Lagunoff M, Renne R, Ganem D. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 1997;100:2606-10.
193. Lennette ET, Blackbourn DJ, Levy JA. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996;348:858-61.
194. Melbye M, Cook PM, Hjalgrim H, Begrrup K, Simpson GR, Biggar RJ, et al. Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int J Cancer 1998;77:543-8.
195. Raab MS, Albrecht JC, Birkmann A, Yaguboglu S, Lang D, Fleckenstein B, et al. The Immunogenic Glycoprotein gp35-37 of Human Herpesvirus 8 Is Encoded by Open Reading Frame K8.1. J Virol 1998;72:6725-31.
196. Chandran B, Bloomer C, Chan SR, Zhu L, Goldstein E, Horvat R. Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. Virology 1998;249:140-9.
197. Chatlynne LG, Lapps W, Handy M, Huang YQ, Masood R, Hamilton AS,et al. Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood 1998;92:53-8.
198. Blauvelt A, Sei S, Cook PM, Schulz TF, Jeang KT. Human herpesvirus 8 infection occurs following adolescence in the United States. J Infect Dis 1997;176:771-4.
199. Bourboulia D, Whitby D, Boshoff C, Newton R, Beral V, Carrara H, et al. Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection. JAMA 1998;280:31-2.
200. Angeloni A, Heston L, Uccini S, Sirianni MC, Cottoni F, Masala MV, et al. High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. J Infect Dis 1998;177:1715-8.
201. Regamey N, Cathomas G, Schwager M, Wernli M, Harr T, Erb P. High human herpesvirus 8 seroprevalence in the homosexual population in Switzerland. J Clin Microbiol 1998;36:1784-6.
202. Manns A, Strickler HD, Hanchard B, Manassaram DM, Waters D, Ablashi DV. Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica. J Natl Cancer Inst 1998;90:1102-4.
203. Whitby D, Luppi M, Barozzi P, Boshoff C, Weiss RA, Torelli G. Human herpesvirus 8 seroprevalence in blood donors and lymphoma patients from different regions of Italy. J Natl Cancer Inst 1998;90:395-7.
204. Oksenhendler E, Cazals-Hatem D, Schulz TF, Barateau V, Grollet L, Sheldon J, et al. Transient angiolymphoid hyperplasia and Kaposi's sarcoma after primary infection with human herpesvirus 8 in a patient with human immunodeficiency virus infection. N Engl J Med 1998;338:1585-90.
205. Lin JC, Lin SC, Mar EC, Pellett PE, Stamey FR, Stewart JA, et al. Is Kaposi's-sarcoma-associated herpesvirus detectable in semen of HIV-infected homosexual men? Lancet 1995;346: 1601-2.
206. Monini P, de Lellis L, Fabris M, Rigolin F, Cassai E. Kaposi's sarcoma-associated herpesvirus DNA sequences in prostate tissue and human semen. N Engl J Med 1996;334:1168-72.
207. Gupta P, Singh MK, Rinaldo C, Ding M, Farzadegan H, Saah A, et al. Detection of Kaposi's sarcoma herpesvirus DNA in semen of homosexual men with Kaposi's sarcoma. AIDS 1996;10:1596-8.
208. Diamond C, Huang ML, Kedes DH, Speck C, Rankin GW Jr., Ganem D, et al. Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis 1997;176:775-7.
209. Diamond C, Brodie SJ, Krieger JN, Huang ML, Koelle DM, Diem K, et al. Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma. J Virol 1998;72:6223-7.
210. Munker R, Tasaka T, Park D, Miller CW, Koeffler HP. HHV-8 (KSHV) does not establish latency in prostate cancer cell lines. Prostate 1997;33:286-8.
211. Blackbourn DJ, Ambroziak J, Lennette E, Adams M, Ramachandran B, Levy JA. Infectious human herpesvirus 8 in a healthy North American blood donor. Lancet 1997;349:609-11.
212. Lefrere JJ, Mariotti M, Girot R, Loiseau P, Herve P. Transfusional risk of HHV-8 infection. Lancet 1997;350:217.
213. Parravicini C, Olsen SJ, Capra M, Poli F, Sirchia G, Gao SJ, et al. Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood 1997;90:2826-9.
214. Rady PL, Hodak E, Yen A, Memar O, Trattner A, Feinmesser M, et al. Detection of human herpesvirus-8 DNA in Kaposi's sarcomas from iatrogenically immunosuppressed patients. J Am Acad Dermatol 1998;38:429-37.
215. Levi F, Franceschi S, La Vecchia C. Kaposi's sarcoma in the Swiss Canton of Vaud, 1974-1990. Eur J Cancer 1993;29A: 1918-9.
216. Kedes DH, Ganem D, Ameli N, Bacchetti P, Greenblatt R. The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA 1997;277:478-81.
217. Neipel F, Albrecht JC, Fleckenstein B. Human herpesvirus 8 - the first human Rhadinovirus. J Natl Canncer Inst Monogr 1998;(23):73-7.
218. Goedert JJ, Kedes DH, Ganem D. Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA. Lancet 1997;349:1368.
219. Olsen SJ, Chang Y, Moore PS, Biggar RJ, Melbye M. Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985. AIDS 1998:12:1921-5.
220. Sosa C, Klaskala W, Chandran B, Soto R, Sieczkuwski L, Wu MH, et al. Human herpesvirus 8 as a potential sexually transmitted agent in Honduras. J Infect Dis 1998;178:547-51.
221. Dupin N, Marcelin AG, Gorin I, Bossi P, Franck N, Weill B, et al. Prevalence of human herpesvirus 8 infection measured by antibodies to a latent nuclear antigen in patients with various dermatologic diseases. Arch Dermatol 1998;134:700-2.
222. Miller G, Heston L, Grogan E, et al. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J Virol 1997;71:313-24.