AIDS-related Kaposi's sarcoma: A template for the translation of molecular pathogenesis into targeted therapeutic approaches

Hematology/Oncology Clinics of North America

Volumn 10, Issue 5, 1996, Pages 1031-1049

  Karp, J E ^a   Pluda, J M ^a   Yarchoan, R ^a  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTISENSE OLIGODEOXYNUCLEOTIDE; BASIC FIBROBLAST GROWTH FACTOR; CHORIONIC GONADOTROPIN; ENDOGLIN; FUMAGILLOL CHLOROACETYLCARBAMATE; GROWTH FACTOR; INTERLEUKIN 12; INTERLEUKIN 6; PENTOSAN POLYSULFATE; SCATTER FACTOR; SURAMIN; THALIDOMIDE; TRANSACTIVATOR PROTEIN; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANGIOGENESIS; IMMUNE RESPONSE; IMMUNOSTIMULATION; KAPOSI SARCOMA; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TRANSACTIVATION;

EID: 0029789166     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(05)70383-X     Document Type: Article

References (132)

1. S.L. Abboud M. Pinzani Peptide growth factors stimulate macrophage colony-stimulating factor in murine stromal cells Blood 78 1991 103
2. P.C. Adamson J. Bailey J.M. Pluda The pharmacokinetics of all- trans- retinoic acid administered on an intermittent schedule J Clin Oncol 13 1995 1238
3. L.P. Aiello R.L. Avery P.G. Arrigg Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders N Engl J Med 331 1994 1480
4. A. Albini G. Barillari R. Benelli Angiogenic properties of human immunodeficiency virus type I Tat protein Proc Natl Acad Sci USA 92 1995 4838
5. M.J. Aman G. Rudolf J. Goldschmitt Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells Blood 82 1993 2371
6. MAPK/ERK-2 in Kaposi's cells J Clin Invest 92 1993 848
7. R. Anand S. Nayyar T.A. Galvin Sodium pentosan polysulfate (PPS), an anti-HIV agent also exerts synergism with AZT, lymphoproliferative activity, and virus enhancement AIDS Res Human Retroviruses 6 1990 679
8. A.L. Angiolillo C. Sgadari D.D. Taub Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo J Exp Med 182 1995 155
9. J. Bailey J.M. Pluda A. Foli Phase I/II study of intermittent all-trans retinoic acid, alone and in combination with interferon alfa-2a, in patients with epidemic Kaposi's sarcoma J Clin Oncol 13 1995 1966
10. G. Barillari L. Buonaguro V. Fiorelli Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression J Immunol 149 1992 3727
11. G. Barillari R. Gendelman R.C. Gallo The Tat protein of human immunodeficiency virus type I, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence Proc Natl Acad Sci USA 90 1993 7941
12. R. Bataille B. Barlogie Z.Y. Lu Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma Blood 86 1995 685
13. M. Benezra I. Vlodasky R. Ishai-Michaeli Thrombin-induced release of active basic fibroblast growth factor–heparan sulfate complexes from subendothelial extracellular matrix Blood 81 1993 3324
14. A. Bergamini C.F. Perno L. Dini Macrophage colony stimulating factor enhances the susceptibility of macrophages to infection by human immunodeficiency virus and reduces the activity of compounds that inhibit virus binding Blood 84 1994 3405
15. D.L. Birx R.R. Redfield K. Tencer Induction of interleukin-6 during human immunodeficiency virus infection Blood 76 1990 2303
16. D.K. Biswas C.M. Ahlers B.J. Dezube Cooperative inhibition of NF-kB and Tat-induced superactivation of human immunodeficiency virus type I long terminal repeat Proc Natl Acad Sci USA 90 1993 11044
17. L. Bonhomme G. Fredj S. Averous Topical treatment of epidemic Kaposi's sarcoma with all-trans retinoic acid Ann Oncol 2 1991 234
18. D. Boraschi A. Rambaldi A. Sica Endothelial cells express the interleukin-1 receptor type I Blood 78 1991 1262
19. D.P. Bottaro J.S. Rubin D.L. Faletto Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product Science 251 1991 802
20. 3 for angiogenesis Science 264 1994 569
21. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels Cell 79 1994 1157
22. F.J. Burrows P.E. Thorpe Vascular targeting—a new approach to the therapy of solid tumors Pharmacol Ther 64 1994 155
23. F. Bussolino M.F. DiRenzo M. Zich Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth J Cell Biol 119 1992 629
24. S. Chatterjee P.R. Johnson K.K. Wong Jr Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vector Science 258 1992 1485
25. M. Clerici D.R. Lucey J.A. Berzofsky Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro Science 262 1993 1721
26. J. Corbeil E. Rapaport D.D. Richman Antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells J Clin Invest 93 1994 1981
27. R.J. D'Amato M.S. Loughnan E. Flynn Thalidomide is an inhibitor of angiogenesis Proc Natl Acad Sci USA 91 1994 4082
28. D.K. Dalton S. Pitts-Meek S. Keshav Multiple defects of immune cell function in mice with disrupted interferon-gamma genes Science 259 1993 1739
29. K.M. Dameron O.V. Volpert M.A. Tainsky Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1 Science 265 1994 1582
30. E. De Clercq Suramin: A potent inhibitor of the reverse transcriptase of RNA tumor viruses Cancer Lett 8 1979 9
31. P. Delli-Bovi A.M. Curatola K.M. Newman Processing, secretion and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential Mol Cell Biol 8 1988 2933
32. R. DeVore D.R. Johnson C. Hellerquvist A Phase I study of the anti-neovascularization drug CM-101 [abstract] Proc ASCO 14 1995 487
33. B.J. Dezube Pentoxifylline for the treatment of infection with human immunodeficiency virus Clin Infect Dis 18 1994 285
34. C.A. Dinarello Interleukin-1 and interleukin-1 antagonism Blood 77 1991 1627
35. D. Emilie J. Wijdenes C. Gisselbrecht Administration of an anti–interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: Effect on lymphoma growth and on B clinical symptoms Blood 84 1994 2472
36. B. Ensoli G. Barillari S.Z. Salahuddin Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients Nature 345 1990 84
37. B. Ensoli L. Buonaguro G. Barillari Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation J Virol 67 1993 277
38. B. Ensoli R. Gendelman P. Markham Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma Nature 371 1994 674
39. B. Ensoli P. Markham V. Kao Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor: A novel strategy for the therapy of KS J Clin Invest 94 1994 1736
40. B. Ensoli S. Nakamura S.Z. Salahuddin AIDS-Kaposi's sarcoma–derived cells express cytokines with autocrine and paracrine growth effects Science 243 1989 223
41. R.A.B. Ezekowitz J.B. Mulliken J. Folkman Interferon-alfa-2a for life-threatening hemangiomas of infancy N Engl J Med 326 1992 1456
42. F. Fazely B.J. Dezube J. Allen-Ryan Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type I in human peripheral blood mononuclear cells and in cultured T cells Blood 77 1991 1653
43. V. Fiorelli R. Gendelman F. Samaniego Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS–Kaposi's sarcoma spindle cells J Clin Invest 95 1995 1723
44. M. Fischl Antiretroviral therapy in combination with interferon for AIDS-related Kaposi's sarcoma Am J Med 90 suppl 1991 2S
45. J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other diseases Nature Med 1 1995 27
46. J. Folkman D. Ingber Inhibition of angiogenesis Semin Cancer Biol 3 1992 89
47. J. Folkman M. Klagsbrun J. Sasse A heparin-binding angiogenic protein—basic fibroblast growth factor—is stored within the basement membrane Am J Pathol 130 1988 393
48. T. Fotsis M. Pepper H. Adlercreutz Genistein, a dietary-derived inhibitor of in vitro angiogenesis Proc Natl Acad Sci USA 90 1993 2690
49. A.E. Friedman-Kiehn B.R. Saltzman Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi's sarcoma J Am Acad Dermatol 22 1990 1237
50. D.P. Gearing M.R. Comeau D.J. Friend The IL-6 signal transducer gp130: An oncostatin M receptor and affinity converter for the LIF receptor Science 255 1992 1434
51. E.V. Granowitz B.D. Clark E. Vannier Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1–induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes Blood 79 1992 2356
52. R.I. Grove C. Eberhardt S. Abid Oncostatin M is a mitogen for rabbit vascular smooth muscle cells Proc Natl Acad SCI USA 90 1993 823
53. P.J. Harris Treatment of Kaposi's sarcoma and other manifestations of AIDS with human chorionic gonadotropin Lancet 346 1995 118
54. R.H. Haubrich C. Flexner M.M. Lederman A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection J Infect Dis 172 1995 1246
55. C. Hellerquvist R. DeVore G. Thurman Cytokine production in cancer patients receiving the anti-neovascularization drug CM-101 [abstract] Proc ASCO 14 1995 488
56. C.G. Hellerquvist G.B. Thurman D.L. Page Antitumor effects of GBS toxin: A polysaccharide exotoxin from group-B beta-hemolytic streptococcus J Cancer Res Clin Oncol 120 1993 63
57. F. Herrmann M. Andreeff H.-J. Gruss Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression Blood 78 1991 2070
58. T. Hirano Interleukin 6 (IL-6) and its receptor: Their role in plasma cell neoplasias Int J Cloning 9 1991 166
59. F.M. Hofman A.D. Wright M.M. Dohadwala Exogenous Tat protein activates human endothelial cells Blood 82 1993 2774
60. J.P. Horwitz J. Chua M. Noel Nucleosides. V. The monomesylates of 1-(2′-deoxy-B-D-xylofuranosyl)thymidine Journal of Organic Chemistry 29 1964 2076
61. O.M.Z. Howard K.A. Clouse C. Smith Soluble tumor necrosis factor receptor: Inhibition of human immunodeficiency virus activation Proc Natl Acad Sci USA 90 1993 2335
62. H1 CD4+ T cells through IL-12 produced by Listeria- induced macrophages Science 260 1993 547
63. D. Ingber T. Fujita S. Kishimoto Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth Nature 348 1990 555
64. A. Iyer T.E. Kmiecik M. Park Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene Cell Growth Differ 1 1990 87
65. J.E. Karp S. Broder The pathogenesis of AIDS lymphomas: A foundation for addressing the challenges of therapy and prevention Leukemia and Lymphoma 8 1992 167
66. J.E. Karp S. Broder New directions in molecular medicine Cancer Res 54 1994 663
67. G. Kaur M. Stetler-Stevenson S. Sebers Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275 J Natl Cancer Inst 84 1992 1736
68. K.J. Kim B. Li J. Winer Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo Nature 362 1993 841
69. T. Kishimoto S. Akira M. Narazaki Interleukin-6 family of cytokines and gp130 Blood 86 1995 1243
70. K. Kitano C.N. Abboud D.H. Ryan Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type I infection in bone marrow stem cells Blood 77 1991 1699
71. D.E. Kleiner Jr W.G. Stetler-Stevenson Structural biochemistry and activation of matrix metalloproteases Curr Opin Cell Biol 5 1993 891
72. T.E. Kmiecik J.R. Keller E. Rosen Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells Blood 80 1992 2452
73. A.E. Koch P.J. Polverini S.L. Kunkel Interleukin-8 as a macrophage-derived mediator of angiogenesis Science 258 1992 1798
74. E.C. Kohn M.A. Sandeen L.A. Liotta In vivo efficacy of a novel inhibitor of selected transduction pathways including calcium, arachidonate, and inositol phosphates Cancer Res 52 1992 3208
75. M. Komada N. Kitamura The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor Oncogene 8 1993 2381
76. R.J. Kreitman C.B. Siegall D.J.P. Fitzgerald Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma Blood 79 1992 1775
77. S.E. Krown Interferon and other biologic agents for the treatment of Kaposi's sarcoma Hematol Oncol Clin North Am 5 1991 311
78. S.E. Krown J.W.M. Gold D. Niedzwiecki Interferon-alpha with zidovudine: Safety, tolerance, and clinical and virologic effects in patients with Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS) Ann Intern Med 112 1990 812
79. S.E. Krown J. Paredes D. Bundow Interferon-alpha, zidovudine, and granulocyte-macrophage colony-stimulating factor: A phase I AIDS Clinical Trials Group study in patients with Kaposi's sarcoma associated with AIDS J Clin Oncol 10 1992 1344
80. H.C. Lane J.A. Kovacs J. Feinberg Anti-retroviral effects of interferon-alpha in AIDS-associated Kaposi's sarcoma Lancet 2 1988 1218
81. A.M. Levine AIDS-related malignancies: The emerging epidemic J Natl Cancer Inst 85 1993 1382
82. J. Lisziewicz D. Sun B. Trapnell An autoregulated dual-function anti-tat gene for human immunodeficiency virus type I gene therapy J Virol 69 1995 206
83. Y. Lunardi-Iskander J.L. Bryant R.A. Zeman Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone Nature 375 1995 64
84. Y. Lunardi-Iskander P. Gill V.H. Lam Isolation and characterization of an immortal neoplastic cell line (KS Y-1) from AIDS-associated Kaposi's sarcoma J Natl Cancer Inst 87 1995 974
85. A.D. Luster J.C. Unkeless J.V. Ravetch Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins Nature 315 1985 672
86. T.E. Maione G.S. Gray J. Petro Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides Science 247 1990 77
87. S.A. Miles O. Martinez-Maza A. Rezai Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma–derived cells Science 255 1992 1432
88. S.A. Miles A.R. Rezai J.F. Salazar-Gonzalez AIDS Kaposi sarcoma–derived cells produce and respond to interleukin 6 Proc Natl Acad Sci USA 87 1990 4068
89. A.N. Murphy E.J. Unsworth W.G. Stetler-Stevenson Tissue inhibitor of metalloproteinase-2 inhibits b-FGF–induced human microvascular endothelial cell proliferation J Cell Physiol 157 1993 351
90. C. Myers M. Cooper C. Stein A novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer J Clin Oncol 10 1992 881
91. C.E. Myers R.V. LaRocca M.R. Cooper Role of suramin in cancer biology and treatment S. Broder Molecular Foundations of Oncology 1991 Williams and Wilkins Baltimore 419
92. Y.M. Naidu E.M. Rosen R. Zitnick Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma Proc Natl Acad Sci USA 91 1994 5281
93. B.C. Nair A.L. DeVico S. Nakamura Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as Oncostatin M Science 255 1992 1430
94. S. Nakamura S. Sakurada S.Z. Salahuddin Inhibition of development of Kaposi's sarcoma–related lesions by a bacterial cell wall complex Science 255 1992 1437
95. A. Ogata N. Nishimoto Y. Shima Inhibitory effects of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction Blood 84 1994 3040
96. T.A. Olson D. Mohanraj L.F. Carson Vascular permeability factor gene expression in normal and neoplastic ovaries Cancer Res 54 1994 276
97. E.M. Paleolog S.-A.J. Delasalle W.A. Buurman Functional activities of receptors for tumor necrosis factor-a on human vascular endothelial cells Blood 84 1994 2578
98. C.-F. Perno D.A. Cooney W.-Y. Gao Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocytes/macrophages Blood 80 1992 995
99. K.H. Plate G. Breier H.A. Weich Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo Nature 359 1992 845
100. J.M. Pluda D.R. Parkinson E. Feigal Noncytotoxic approaches to the treatment of HIV-associated Kaposi's sarcoma Oncology 7 1993 25
101. J.M. Pluda L.E. Shay A. Foli Administration of pentosan polysulfate to patients with human immunodeficiency virus–associated Kaposi's sarcoma J Natl Cancer Inst 85 1993 1585
102. J.M. Pluda K. Wyvill W.D. Figg A Phase I trial of an angiogenesis inhibitor, TNP-470 (AGM-1470), administered to patients with HIV-associated Kaposi's sarcoma [abstract] Proc ASCO 13 1994 51
103. C.S. Rabkin R.J. Biggar J.W. Horm Increasing incidence of cancers associated with the human immunodeficiency virus epidemic Int J Cancer 47 1991 692
104. S.F. Radka S. Nakamura S. Sakurada Correlation of Oncostatin M secretion by human retrovirus–infected cells with potent growth stimulation of cultured spindle cells from AIDS–Kaposi's sarcoma J Immunol 150 1993 5195
105. L.M. Reyno M.J. Egorin M.A. Eisenberger Development and validation of a pharmacokinetically based fixed dosing scheme for suramin J Clin Oncol 13 1995 2187
106. J.S. Rubin A.M.-L. Chan D.P. Bottaro A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor Proc Natl Acad Sci USA 88 1991 415
107. M.W. Saville A. Foli S. Broder vitro activity if TNP-470, a novel angiogenesis inhibitor in Kaposi's sarcoma (KS)–related spindle cells J Cell Biochem 17E suppl 1993 22
108. D.T. Scadden H.A. Bering J.D. Levin Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome–associated Kaposi's sarcoma J Clin Oncol 9 1991 802
109. D.T. Scadden M. Zeira A. Woon Human immunodeficiency virus infection of human bone marrow stromal fibroblasts Blood 76 1990 317
110. yes tyrosine kinase J Immunol 149 1992 1676
111. C. Schmidt F. Bladt S. Goedecke Scatter factor/hepatocyte growth factor is essential for liver development Nature 373 1995 699
112. R. Seifert B. Zhao B. Christ Cytokinetic studies on the aortic endothelium and limb bud vascularization in avian embryos Anat Embryol 186 1992 601
113. S.D. Shapiro E.J. Campbell D.K. Kobayashi Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis in interferon-gamma J Clin Invest 86 1990 1204
114. D. Shweiki A. Itin D. Soffer Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 359 1992 843
115. N. Sidell T. Taga T. Hirano Retinoic acid–induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors J Immunol 146 1991 3809
116. E. Sonnenberg D. Meyer K.M. Weidner Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development J Cell Biol 123 1993 223
117. B.A. Sullenger H.F. Gallardo G.A. Unger Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication Cell 63 1990 601
118. A.A. te Velde R.J.F. Huijbens K. Heije Interleukin-4 (IL-4) inhibits secretion of IL-1b, tumor necrosis factor-a, and IL-6 by monocytes Blood 76 1990 1392
119. H. Tilg W. Vogel C.A. Dinarello Interferon-a induces circulating tumor necrosis factor receptor p55 in humans Blood 85 1995 433
120. G. Trinchieri Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type I and cytotoxic lymphocytes Blood 84 1994 4008
121. I. Tsarfaty S. Rong J.H. Resau The met proto-oncogene mesenchymal to epithelial cell conversion Science 263 1994 98
122. I. Vlodasky Z. Fuks R. Ishai-Michaeli Extracellular matrix-resident basic fibroblast growth factor: Implication for the control of angiogenesis J Cell Biochem 45 1991 167
123. E.E. Voest B.M. Kenyon M.S. O-Reilly Inhibition of angiogenesis in vivo by interleukin 12 J Natl Cancer Inst 87 1995 581
124. T. Vogel N. Guo H.C. Krutzsch Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin J Cell Biochem 53 1993 74
125. J. von Roenn C. von Gunten M. Mullane All trans-retinoic acid (TRA) in the treatment of AIDS-related Kaposi's sarcoma: A phase II Illinois Cancer Center study Proc ASCO 12 1993 51
126. R.W. Wagner Gene inhibition using antisense oligodeoxynucleotides Nature 372 1994 333
127. K.M. Weidner G. Hartmann M. Sachs Properties and function of scatter factor, hepatocyte growth factor and its receptor c-met. Am J Respir Cell Mol Biol 8 1993 229
128. R. Yarchoan S. Broder Preliminary results on the use of dideoxynucleosides in the therapy of AIDS R.M. Chanock R.A. Lerner F. Brow Vaccines 87: Modern Approaches to New Vaccines 1987 Cold Spring Harbor Laboratory Cold Spring Harbor, NY
129. R. Yarchoan R.W. Klecker K.J. Weinhold Administration of 3′-azido-3′-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex Lancet 1 1986 575
130. R. Yarchoan J.M. Pluda C.-F. Perno Anti-retroviral therapy of human immunodeficiency virus infection: Current strategies and challenges for the future Blood 78 1991 859
131. V. Zabrenetzky C.C. Harris P.S. Steeg Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung, and breast carcinoma cell lines Int J Cancer 59 1994 191
132. G. Zugmaier M. Lippman A. Wellstein Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals J Natl Cancer Inst 84 1992 1716