Sustained Expression of Therapeutic Level of Factor IX in Hemophilia B Dogs by AAV-Mediated Gene Therapy in Liver

Molecular Therapy

Volumn 1, Issue 2, 2000, Pages 154-158

  Wang, Lili ^a   Nichols, Timothy C ^b   Read, Marjorie S ^b   Bellinger, Dwight A ^b   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

AAV vectors; Expression; Factor IX; Hemophilia B; Hemophilic dogs; Intraportal; Liver enzyme

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BLOOD CLOTTING FACTOR 9; COMPLEMENTARY DNA; GAMMA GLUTAMYLTRANSFERASE;

ADENO ASSOCIATED VIRUS; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; BLOOD CLOTTING TIME; DOG; ENHANCER REGION; GENE THERAPY; GENE VECTOR; GENETICS; HEMOPHILIA B; LIVER; METABOLISM; METHODOLOGY; PARTIAL THROMBOPLASTIN TIME; PROMOTER REGION; TIME;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; DEPENDOVIRUS; DNA, COMPLEMENTARY; DOGS; ENHANCER ELEMENTS (GENETICS); FACTOR IX; GAMMA-GLUTAMYLTRANSFERASE; GENE THERAPY; GENETIC VECTORS; HEMOPHILIA B; LIVER; PARTIAL THROMBOPLASTIN TIME; PROMOTER REGIONS (GENETICS); TIME FACTORS; WHOLE BLOOD COAGULATION TIME;

EID: 0034137797     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0031     Document Type: Article

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