Stability in synapse number and size at 2 Hr after long-term potentiation in hippocampal area CA1

Journal of Neuroscience

Volumn 18, Issue 2, 1998, Pages 658-671

  Sorra, Karin E ^b   Harris, Kristen M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Area CA1; Axonal boutons; Dendritic spines; Disector; Hippocampal slice; Hippocampus; In vitro; Long term potentiation; Postsynaptic density; Serial electron microscopy; Three dimensional reconstructions; Ultrastructure

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DENSITY; CELL ULTRASTRUCTURE; DENDRITE; DENDRITIC SPINE; ELECTRON MICROSCOPY; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE; SYNAPTIC TRANSMISSION;

EID: 0031962241     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-02-00658.1998     Document Type: Article

References (9)

1. Applegate MD, Kerr DS, Landfield PW (1987) Redistribution of synaptic vesicles during long-term potentiation in the hippocampus. Brain Res 401:401-406.
2. Bailey CH, Kandel ER (1993) Structural changes accompanying memory storage. Annu Rev Physiol 55:397-426.
3. Bear MF, Abraham WC (1996) Long-term depression in hippocampus. Annu Rev Neurosci 19:437-462.
4. Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
5. Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol (Lond) 232:331-356.
6. Braendgaard H, Gundersen HJG (1986) The impact of recent stereological advances on quantitative studies of the nervous system. J Neurosci Methods 18:39-78.
7. Buchs P-A, Muller D (1996) Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses. Proc Natl Acad Sci USA 93:8040-8045.
8. Chang FF, Greenough WT (1984) Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice. Brain Res 309:35-46.
9. Chang FF, Isaacs KR, Greenough WT (1991) Synapse formation occurs in association with the induction of long-term potentiation in two-year-old rat hippocampus in vitro. Neurobiol Aging 12:517-522.