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Volumn 7, Issue 3, 2000, Pages 241-249

p53 and thymic 'death by neglect': Thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent

Author keywords

Apoptosis; Death by neglect; Double positive thymocytes; p53; Thymic epithelial cells; Tumor suppresor protein

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MUTANT PROTEIN; PROTEIN P53;

EID: 0034125553     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400657     Document Type: Article
Times cited : (5)

References (37)
  • 2
    • 0031727316 scopus 로고    scopus 로고
    • Thymocyte selection: Not by TcR alone
    • Amsen D and Kruisbeek AM (1998) Thymocyte selection: not by TcR alone. Immunol. Rev. 165: 209-229
    • (1998) Immunol. Rev. , vol.165 , pp. 209-229
    • Amsen, D.1    Kruisbeek, A.M.2
  • 3
    • 0032966843 scopus 로고    scopus 로고
    • Thymus-derived glucocorticoids and the regulation of antigen specific T cell development
    • Tolosa E and Ashwell JD (1999) Thymus-derived glucocorticoids and the regulation of antigen specific T cell development. Neuroimmunomodulation 6: 90-96
    • (1999) Neuroimmunomodulation , vol.6 , pp. 90-96
    • Tolosa, E.1    Ashwell, J.D.2
  • 4
    • 0025966665 scopus 로고
    • Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo
    • Gutierrez JC and Palacios R (1991) Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo. Proc. Natl. Acad. Sci. USA 88: 642-646
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 642-646
    • Gutierrez, J.C.1    Palacios, R.2
  • 5
    • 0025339512 scopus 로고
    • Self-nonself discrimination by T cells
    • von Boehmer H and Kisielow P (1990) Self-nonself discrimination by T cells. Science 248: 1369-1373
    • (1990) Science , vol.248 , pp. 1369-1373
    • Von Boehmer, H.1    Kisielow, P.2
  • 7
    • 0025971637 scopus 로고
    • Rescue of thymocytes and T cell hybridomas from GC-induced apoptosis by stimulation via the TcR/CD3 complex: A possible in vitro model for positive selection of the T cell repertoire
    • Iwata M, Hanaoka S and Sato K (1991) Rescue of thymocytes and T cell hybridomas from GC-induced apoptosis by stimulation via the TcR/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21: 643-648
    • (1991) Eur. J. Immunol. , vol.21 , pp. 643-648
    • Iwata, M.1    Hanaoka, S.2    Sato, K.3
  • 8
    • 0028233225 scopus 로고
    • Steroid production in the thymus: Implications for thymocyte selection
    • Vacchio MS, Papadopoulus V and Ashwell JD (1994) Steroid production in the thymus: Implications for thymocyte selection. J. Exp. Med. 179: 1835-1846
    • (1994) J. Exp. Med. , vol.179 , pp. 1835-1846
    • Vacchio, M.S.1    Papadopoulus, V.2    Ashwell, J.D.3
  • 9
    • 0025613973 scopus 로고
    • Programmed T lymphocytes death. Cell activation and steroid-induced pathways are mutually antagonistic
    • Zacharchuk CM, Mercep M, Chakraborti PK, Simons JR SS and Ashwell JD (1990) Programmed T lymphocytes death. Cell activation and steroid-induced pathways are mutually antagonistic. J. Immunol. 145: 4037-4045
    • (1990) J. Immunol. , vol.145 , pp. 4037-4045
    • Zacharchuk, C.M.1    Mercep, M.2    Chakraborti, P.K.3    Simons S.S., Jr.4    Ashwell, J.D.5
  • 10
    • 0029895803 scopus 로고    scopus 로고
    • T cell receptor-independent apoptosis of thymocyte clones induced by a thymic epithelial cell line is mediated by steroids
    • Zilberman Y, Yefenof E, Oron E, Dorogin A and Guy R (1996) T cell receptor-independent apoptosis of thymocyte clones induced by a thymic epithelial cell line is mediated by steroids. Cell. Immunol. 170: 78-84
    • (1996) Cell. Immunol. , vol.170 , pp. 78-84
    • Zilberman, Y.1    Yefenof, E.2    Oron, E.3    Dorogin, A.4    Guy, R.5
  • 11
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T (1993b) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 13
    • 0027407260 scopus 로고
    • Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA
    • Halazonetis TD, Davis LJL and Kandil AN (1993) Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA. EMBO J. 12: 1021-1028
    • (1993) EMBO J. , vol.12 , pp. 1021-1028
    • Halazonetis, T.D.1    Davis, L.J.L.2    Kandil, A.N.3
  • 14
    • 0031882549 scopus 로고    scopus 로고
    • Apoptosis by p53: Mechanism, regulation, and clinical implications
    • Vogt Sionov R and Haupt Y (1998) Apoptosis by p53: mechanism, regulation, and clinical implications. Springer Semin. Immunopathol. 19: 345-362
    • (1998) Springer Semin. Immunopathol. , vol.19 , pp. 345-362
    • Vogt Sionov, R.1    Haupt, Y.2
  • 15
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild type p53 are more resistant to induction of apoptosis by some agents
    • Lotem J and Sachs L (1993) Hematopoietic cells from mice deficient in wild type p53 are more resistant to induction of apoptosis by some agents. Blood 82: 1092-1096
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 16
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 20
    • 0029880454 scopus 로고    scopus 로고
    • + stage of thymocytes differentiation in the absence of TcR rearrangement
    • + stage of thymocytes differentiation in the absence of TcR rearrangement. J. Exp. Med. 183: 1923-1928
    • (1996) J. Exp. Med. , vol.183 , pp. 1923-1928
    • Jiang, D.1    Lenardo, M.J.2    Zuniga-Pflucker, J.C.3
  • 23
    • 0033119782 scopus 로고    scopus 로고
    • Apoptosis of thymic lymphoma clones by thymic epithelial cells: A putative model for 'death by neglect'
    • Zilberman Y, Katzav S, Yefenof E, Rosenheimer-Goudsmid N, Dorogin A and Guy R (1999) Apoptosis of thymic lymphoma clones by thymic epithelial cells: a putative model for 'death by neglect'. Immunol. Lett. 67: 95-104
    • (1999) Immunol. Lett. , vol.67 , pp. 95-104
    • Zilberman, Y.1    Katzav, S.2    Yefenof, E.3    Rosenheimer-Goudsmid, N.4    Dorogin, A.5    Guy, R.6
  • 24
    • 0029847788 scopus 로고    scopus 로고
    • Induction of apoptosis and p53 expression in immature thymocytes by direct interaction with thymic epithelial cells
    • Schreiber L, Sharabi Y, Schwartz D, Goldfinger N, Brodie C, Rotter V and Shoham J (1996) Induction of apoptosis and p53 expression in immature thymocytes by direct interaction with thymic epithelial cells. Scand. J. Immunol. 44: 314-322
    • (1996) Scand. J. Immunol. , vol.44 , pp. 314-322
    • Schreiber, L.1    Sharabi, Y.2    Schwartz, D.3    Goldfinger, N.4    Brodie, C.5    Rotter, V.6    Shoham, J.7
  • 25
    • 0030689782 scopus 로고    scopus 로고
    • The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo
    • Reinke V and Lozano G (1997) The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo. Oncogene 15: 1527-1534
    • (1997) Oncogene , vol.15 , pp. 1527-1534
    • Reinke, V.1    Lozano, G.2
  • 26
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocytes apoptosis by propidium iodide staining and flow cytometry
    • Nicolleti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C (1991) A rapid and simple method for measuring thymocytes apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279
    • (1991) J. Immunol. Methods , vol.139 , pp. 271-279
    • Nicolleti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 27
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A, Harris AW, Jaks T and Cory S (1994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 73: 329-339
    • (1994) Cell , vol.73 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jaks, T.3    Cory, S.4
  • 28
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden KH and Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9: 2170-2183
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 29
    • 0022472735 scopus 로고
    • Monoclonal antibody analysis of p53 expression in normal and transformed cells
    • Yewdell JW, Gannon JV and Lane DP (1986) Monoclonal antibody analysis of p53 expression in normal and transformed cells. J. Virol. 59: 444-452
    • (1986) J. Virol. , vol.59 , pp. 444-452
    • Yewdell, J.W.1    Gannon, J.V.2    Lane, D.P.3
  • 30
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
    • Ganon JV, Greaves R, Iggo R and Lane DP (1990) Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J. 9: 1595-1602
    • (1990) EMBO J. , vol.9 , pp. 1595-1602
    • Ganon, J.V.1    Greaves, R.2    Iggo, R.3    Lane, D.P.4
  • 32
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • Levine AJ, Momand J and Finlay CA (1991) The p53 tumor suppressor gene. Nature 351: 453-456
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 35
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • Blandino G, Levine AJ and Oren M (1999) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 18: 477-485
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 36
    • 0023580383 scopus 로고
    • Clonal analysis of radiation leukemia virus-induced leukemic and preleukemic murine cells
    • Ben-David Y, Yefenof E and Kotler M (1987) Clonal analysis of radiation leukemia virus-induced leukemic and preleukemic murine cells. Cancer Res. 47: 6590-6594
    • (1987) Cancer Res. , vol.47 , pp. 6590-6594
    • Ben-David, Y.1    Yefenof, E.2    Kotler, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.