Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses

Infection and Immunity

Volumn 68, Issue 6, 2000, Pages 3290-3296

  Vemulapalli, Ramesh ^a   He, Yongqun ^a   Boyle, Stephen M ^a   Sriranganathan, Nammalwar ^a   Schurig, Gerhardt G ^a  

^a CENTER FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRUCELLA ABORTUS; BRUCELLOSIS; EXPRESSION VECTOR; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; VACCINATION;

ANIMALS; BACTERIAL PROTEINS; BRUCELLA ABORTUS; BRUCELLA VACCINE; CHAPERONINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENETIC VECTORS; HEAT-SHOCK PROTEINS; LAC OPERON; MICE; MICE, INBRED BALB C; MYCOBACTERIUM BOVIS; PROMOTER REGIONS (GENETICS); SPLEEN; SUPEROXIDE DISMUTASE; TH1 CELLS; VACCINES, SYNTHETIC;

EID: 0034115854     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.6.3290-3296.2000     Document Type: Article

References (41)

1. Acha, P., and B. Szyfres. 1980. Zoonoses and communicable diseases common to man and animals, p. 28-45. Pan American Health Organization, Washington, D.C.
2. Agranovich, I., D. E. Scott, D. Terle, K. Lee, and B. Golding. 1999. Down-regulation of Th2 responses by Brucella abortus, a strong Th1 stimulus, correlates with alterations in the B7.2-CD28 pathway. Infect. Immun. 67: 4418-4426.
3. Allen, C. A., L. Garry Adams, and T. A. Ficht. 1998. Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival. Infect. Immun. 66:1008-1016.
4. Araya, L. N., P. H. Elzer, G. E. Rowe, F. M. Enright, and A. J. Winter. 1989. Temporal development of protective cell-mediated and humoral immunity in BALB/c mice infected with Brucella abortus. J. Immunol. 143:3330-3337.
5. Araya, L. N., and A. J. Winter. 1990. Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum. Infect. Immun. 58:254-256.
6. Batoni, G., G. Maisetta, W. Florio, G. Freer, M. Campa, and S. Senesi. 1998. Analysis of the Mycobacterium bovis hsp60 promoter activity in recombinant Mycobacterium avium. FEMS Microbiol. Lett. 169:117-124.
7. Brett, S. J., J. R. Lamb, J. H. Cox, J. B. Rothbard, A. Mehlert, and J. Ivanyi. 1989. Differential pattern of T cell recognition of the 65-kDa mycobacterial antigen following immunization with the whole protein or peptides. Eur. J. Immunol. 19:1303-1310.
8. Brossier, F., M. Mock, and J. Sirard. 1999. Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines. J. Appl. Microbiol. 87:298-302.
9. Cheville, N. F., A. E. Jensen, S. M. Halling, F. M. Tatum, D. C. Morfitt, S. G. Hennager, W. M. Frerichs, and G. G. Schurig. 1992. Bacterial survival, lymph node changes, and immunologic responses of cattle vaccinated with standard and mutant strains of Brucella abortus. Am. J. Vet. Res. 53:1881-1888.
10. Cheville, N. F., M. G. Stevens, A. E. Jensen, F. M. Tatum, and S. M. Halling. 1993. Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus. Am. J. Vet. Res. 54:1591-1597.
11. Cirillo, J. D., C. K. Stover, B. R. Bloom, W. R. Jacobs, Jr., and R. G. Barletta. 1995. Bacterial vaccine vectors and bacillus Calmette-Guerin. Clin. Infect. Dis. 20:1001-1009.
12. Comerci, D. J., G. D. Pollevick, A. M. Vigliocco, A. C. C. Frasch, and R. A. Ugalde. 1998. Vector development for the expression of foreign proteins in the vaccine strain Brucella abortus S19. Infect. Immun. 66:3862-3866.
13. Corbel, M. J. 1997. Brucellosis: an overview. Emerg. Infect. Dis. 3:213-221.
14. Dellagostin, O. A., G. Esposito, L. J. Eales, J. W. Dale, and J. McFadden. 1995. Activity of mycobacterial promoters during intracellular and extracellular growth. Microbiology 141:1785-1792.
15. Hoffman, P. S., L. Houston, and C. A. Butler. 1990. Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells. Infect. Immun. 58:3380-3387.
16. Jensen, A. E., D. R. Ewalt, N. F. Cheville, C. O. Thoen, and J. B. Payeur. 1996. Determination of stability of Brucella abortus RB51 by use of genomic fingerprint, oxidative metabolism, and colonial morphology and differentiation of strain RB51 from B. abortus isolates from bison and elk. J. Clin. Microbiol. 34:628-633.
17. Killeen, K., D. Spriggs, and J. Mekalanos. 1999. Bacterial mucosal vaccines: Vibrio cholerae as a live attenuated vaccine/vector paradigm. Curr. Top. Microbiol. Immunol. 236:237-254.
18. Kovach, M. E., R. W. Phillips, P. H. Elzer, R. M. Roop II, and K. M. Peterson. 1994. pBBR1MCS: a broad-host-range cloning vector. BioTechniques 16:800-802.
19. Lindquist, S., and E. A. Craig. 1988. The heat-shock proteins. Annu. Rev. Genet. 22:631-677.
20. Littell, R. C., G. A. Milliken, W. W. Stroup, and R. D. Wolfinger. 1996. SAS system for mixed models. SAS Institute, Inc., Cary, N.C.
21. Lord, V. R., G. G. Schurig, J. W. Cherwonogrodzky, M. J. Marcano, and G. E. Melendez. 1998. Field study of vaccination of cattle with Brucella abortus strains RB51 and 19 under high and low disease prevalence. Am. J. Vet. Res. 59:1016-1020.
22. Lowrie, D. B., C. L. Silva, M. J. Colston, S. Ragno, and R. E. Tascon. 1997. Protection against tuberculosis by a plasmid DNA vaccine. Vaccine 15:834-838.
23. McQuiston, J. R., G. G. Schurig, N. Sriranganathan, and S. M. Boyle. 1995. Transformation of Brucella species with suicide and broad host-range plasmids. Methods Mol. Biol. 47:143-148.
24. McQuiston, J. R., R. Vemulapalli, T. J. Inzana, G. G. Schurig, N. Sriranganathan, D. Fritzinger, T. L. Hadfield, R. A. Warren, N. Snellings, D. Hoover, S. M. Halling, and S. M. Boyle. 1999. Genetic characterization of a Tn5-disrupted glycosyltransferase gene homolog in Brucella abortus and its effect on lipopolysaccharide composition and virulence. Infect. Immun. 67: 3830-3835.
25. Miller, J. H. 1992. A short course in bacterial genetics: a laboratory manual and handbook for Escherichia coli and related bacteria. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
26. Oñate, A. A., R. Vemulapalli, E. Andrews, G. G. Schurig, S. Boyle, and H. Folch. 1999. Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus. Infect. Immun. 67:986-988.
27. Palmer, M. V., S. C. Olsen, and N. F. Cheville. 1997. Safety and immunogenicity of Brucella abortus strain RB51 vaccine in pregnant cattle. Am. J. Vet. Res. 58:472-477.
28. Rafie-Kolpin, M., R. C. Essenberg, and J. H. Wyckoff III. 1996. Identification and comparison of macrophage-induced proteins and proteins induced under various stress conditions in Brucella abortus. Infect. Immun. 64:5274-5283.
29. Roop, R. M., II, M. L. Price, B. E. Dunn, S. M. Boyle, N. Sriranganathan, and G. G. Schurig. 1992. Molecular cloning and nucleotide sequence analysis of the gene encoding the immunoreactive Brucella abortus Hsp60 protein, BA60K. Microb. Pathog. 12:47-62.
30. Schurig, G. G., R. M. Roop, T. Bagchi, S. Boyle, D. Buhrman, and N. Sriranganathan. 1991. Biological properties of RB51: a stable rough strain of Brucella abortus. Vet. Microbiol. 28:171-188.
31. Scott, D. E., I. Agranovich, J. Inman, M. Gober, and B. Golding. 1997. Inhibition of primary and recall allergen-specific T helper cell type 2-mediated responses by a T helper cell type 1 stimulus. J. Immunol. 159:107-116.
32. Shinnick, T. M. 1991. Heat shock proteins as antigens of bacterial and parasitic pathogens. Curr. Top. Microbiol. Immunol. 167:145-150.
33. Silva, C. L., M. F. Silva, R. C. L. R. Pietro, and D. B. Lowrie. 1996. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect. Immun. 64:2400-2407.
34. Stevens, T. L., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255-258.
35. Vemulapalli, R., S. Cravero, C. L. Calvert, T. E. Toth, S. M. Boyle, N. Sriranganathan, and G. G. Schurig. 2000. Characterization of specific immune responses of mice inoculated with recombinant vaccinia virus expressing an 18-kilodalton outer membrane protein of Brucella abortus. Clin. Diagn. Lab. Immunol. 7:114-118.
36. Vemulapalli, R., A. J. Duncan, S. M. Boyle, N. Sriranganathan, T. E. Toth, and G. G. Schurig. 1998. Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51. Infect. Immun. 66:5684-5691.
37. Vemulapalli, R., Y. He, S. Cravero, N. Sriranganathan, S. M. Boyle, and G. G. Schurig. 2000. Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51. Infect. Immun. 68:3286-3289.
38. Weiskirch, L. M., and Y. Paterson. 1997. Listeria monocytogenes: a potent vaccine vector for neoplastic and infectious disease. Immunol. Rev. 158:159-169.
39. Winter, A. J., G. G. Schurig, S. M. Boyle, N. Sriranganathan, J. S. Bevins, F. M. Enright, P. H. Elzer, and J. D. Kope. 1996. Protection of BALB/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4. Am. J. Vet. Res. 57:677-683.
40. Wise, D. J., N. Sriranganathan, S. M. Boyle, and G. G. Schurig. 1998. Evaluation of the intracellular growth of various Brucella species in J774.A1 and PU5-1.8 macrophage-like cell lines as an in vitro model of assessing attenuation in vivo, p. 93-110. In J. F. Frank (ed.), Networking in brucellosis research II. Proceedings of the UNU/BIOLAC Brucellosis Workshop. United Nations University Press, Tokyo, Japan.
41. Zegers, N. D., E. Kluter, H. Van Der Stap, E. Van Dura, P. Van Dalen, M. Shaw, and L. Baillie. 1999. Expression of the protective antigen of Bacillus anthracis by Lactobacillus casei: towards the development of an oral vaccine against anthrax. J. Appl. Microbiol. 87:309-314.