Expression of the protective antigen of bacillus anthracis by lactobacillus casei: Towards the development of an oral vaccine against anthrax

Journal of Applied Microbiology

Volumn 87, Issue 2, 1999, Pages 309-314

  Zegers, N D ^a   Kluter, E ^a   Van der Stap, H ^a   Van Dura, E ^a   Van Dalen, P ^a   Shaw, M ^a   Baillie, L ^b  

^a TNO   (Netherlands)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; BACTERIOLOGY; CLONING; DISEASES; ENZYME ACTIVITY; GENE ENCODING; IMMUNE SYSTEM;

'CURRENT; ANTHRAX VACCINES; B.ANTHRACIS; BACILLUS ANTHRACIS; BIOLOGICAL WARFARE AGENTS; EXPRESSION OF HETEROLOGOUS PROTEINS; LACTOBACILLUS CASEI; PROTECTIVE ANTIGENS; SAFER SYSTEM; SIDE EFFECT;

VACCINES;

BACTERIAL VACCINE;

ANTHRAX; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BACILLUS ANTHRACIS; IMMUNOSTIMULATION; LACTOBACILLUS CASEI; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; SPOROGENESIS;

ANTHRAX; BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); LACTOBACILLUS; LACTOBACILLUS CASEI; POSIBACTERIA;

EID: 0032820970     PISSN: 13645072     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2672.1999.00900.x     Document Type: Article

References (5)

1. Bokhout, B.A., Van Gaalen, C. and Van Der Heijden, P.H.J. (1981) A selected water-in-oil emulsion: Composition and usefulness as an immunological adjuvant. Veterinary Immunological Immunopathology 2, 491-500.
2. Coulson, N.M., Fulop, M. and Titball, R.W. (1994) Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge. Vaccine 12(15), 1395-1401.
3. Ivins, B.E., Welkons, S.L., Knudson, G.B. and Little, S.F. (1990) Immunisation against anthrax with aromatic compound-dependent (Aro-) mutants of Bacillus anthracis and with recombinant strains of Bacillus subtilis that produce anthrax protective antigen. Infection and Immunity, 58, 303-308.
4. Miller, J., Mcbride, B.W., Manchee, R.J., Moore, P. and Baillie, L.W. (1998) Production and purification of recombinant protective antigen and protective efficacy against Bacillus anthracis. Letters in Applied Microbiology 26, 56-60.
5. Pouwels, P.H., Leer, R.J. and Boersma, W.J.A. (1996) The potential of Lactobacillus as a carrier for oral immunisation: Development and preliminary characterisation of vector systems for targeted delivery of antigens. Journal of Biotechnology 44, 183-192.