Direct radiation damage to crystalline DNA: What is the source of unaltered base release?

Radiation Research

Volumn 153, Issue 4, 2000, Pages 436-441

  Razskazovskiy, Yuriy ^a   Debije, Michael G ^a   Bernhard, William A ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ANTHRACYCLINE; CYTOSINE; DNA; GUANINE; HYDROXYL RADICAL; OLIGOMER; PHOSPHATE; SUGAR; THYMINE;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; PRIORITY JOURNAL; PROTON TRANSPORT; RADIATION INJURY; X IRRADIATION;

EID: 0034110914     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2000)153[0436:DRDTCD]2.0.CO;2     Document Type: Article

References (37)

1. C. von Sonntag, The Chemical Basis of Radiation Biology. Taylor & Francis, London, 1987.
2. R. E. Krisch, M. B. Flick and C. N. Trumborc, Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA. Radiat. Res. 126, 251-259 (1991).
3. D. M. Close, Radical ions and their reactions in DNA constituents. ESR/ENDOR studies of radiation damage in the solid state. Radiat. Res. 135, 1-15 (1993).
4. D. Becker and M. D. Sevilla, The chemical consequences of radiation damage to DNA. Adv. Radiat. Biol. 17, 121-180 (1993).
5. M. D. Sevilla and D. Becker, Radiation damage in DNA. Electron Spin Resonance (A Specialist Periodical Report) 14, 130-165 (1994).
6. S. G. Swarts, M. D. Sevilla and K. T. Wheeler, Specific DNA base damage produced by irradiation of hydrated DNA. In Radiation Research, Vol. 1 (J. D. Chapman, G. F. Whitmore and W. C. Dewey, Eds.). Academic Press, San Diego, 1991. [Abstract]
7. S. G. Swarts, M. D. Sevilla, D. Becker, C. J. Tokar and K. T. Wheeler, Radiation-induced damage as a function of hydration. I. Release of unaltered bases. Radiat. Res. 129, 333-344 (1992).
8. S. G. Swarts, D. Becker, M. D. Sevilla and K. T. Wheeler, Radiation-induced DNA damage as a function of hydration. II. Base damage from electron-loss centers. Radiat. Res. 145, 304-314 (1996).
9. P. Wolf, G. D. D. Jones and P. O'Neill, Induction of strand breaks in polyribonucleotides and DNA by the sulfate radical-anion-role of electron-loss centres as precursors of strand breakage. Int. J. Radiat. Biol. 64, 7-18 (1993).
10. P. M. Cullis, M. E. Malone and L. A. Merson-Davies, Guanine radical cations are precursors of 7.8-dihydro-8-oxo-2′-deoxyguanosine but are not precursors of immediate strand breaks in DNA. J. Am. Chem. Soc. 118, 2775-2781 (1996).
11. J. R. Milligan, J. A. Aguilera, T. T. D. Nguyen, J. F. Ward, Y. W. Kow, B. He and R. P. Cunningham, Yield of DNA strand breaks after base oxidation of plasmid DNA. Radiat. Res. 151, 3.34-342 (1999).
12. E. S. Henle, R. Roots, W. R. Holley and A. Chatterjee, DNA strand breakage is correlated with unaltered base release after gamma irradiation. Radiat. Res. 143, 144-150 (1995).
13. M. G. Debije and W. A. Bernhard, Free radical yields in crystalline DNA X-irradiated at 4 K. Radiat. Res. 152, 575-581 (1999).
14. M. G. Debijc, M. T. Milano and W. A. Bernhard, DNA responds to ionizing irradiation as an insulator not as a "molecular wire". Angew. Chem. 38, 2752-2756 (1999).
15. C. Ban and M. Sundaralingam, Crystal structure of the self-complementary 5′-purine start decamer d(GCACGCGTGC) in the A-conformation. Biophys. J. 71, 1222-1227 (1996).
16. C. Sadasivan and N. Gautham, Sequence-dependent microheterogeneity of Z-DNA: The crystal and molecular structures of d(CACGCG)d(CGCGTG) and d(CGCACG)d(CGTGCG). J. Mol. Biol. 248, 918-930 (1995).
17. G. L. Quigley, A. H-J. Wang, G. Ughetto, G. van den Marel, J. H. van Boom and A. Rich, Molecular structure of an anticancer drug-DNA complex - daunomycin plus d(CpGpTpApCpG). Proc. Natl. Acad. Sci. USA 77, 7204-7208 (1980).
18. C. A. Frederick, L. D. Williams, G. Ughetto, G. A. van den Marel, J. H. van Boom, A. Rich and A. H-J. Wang, Structural comparison of anticancer drug-DNA complexes: Adriamycin and daunomycin. Biochemistry 29, 2538-2549 (1990).
19. L. A. Lipscomb, M. E. Peek, F. X. Zhou, J. A. Bertrand, D. Van Derveer and L. D. Williams, Water ring structure at DNA interfaces: Hydration and dynamics of DNA-anthracycline complexes. Biochemistry 33, 3649-3659 (1994).
20. 2-saturated aqueous solution. Radiat. Res. 66, 485-498 (1976).
21. M. T. Milano, G. G. Hu, L. D. Williams and W. A. Bernhard, Migration of electrons and holes in crystalline d(CGATCG)-anthracycline complexes X-irradiated at 4 K. Radiat. Res. 150, 101-114 (1998).
22. W. K. Pogozelski and T. D. Tullius, Oxidative strand scission of nucleic acids: Routes initiated by hydrogen abstraction from the sugar moiety. Chem. Rev. 98, 1089-1107 (1998).
23. A. Gugger, R. Batra, P. Rzadek, G. Rist and B. Giese, Spectroscopic evidence for a radical cation as intermediate in a model reaction of the 4′-DNA radical strand cleavage. J. Am. Chem. Soc. 119, 8740-8741 (1997).
24. E. Meggers, D. Kusch, M. Spichty, U. Wille and B. Giese, Electron transfer through DNA in the course of radical-induced strand cleavage. Angew. Chem. 37, 460-462 (1998).
25. D. Becker, T. LaVere and M. D. Sevilla, ESR detection at 77 K of the hydroxyl radical in the hydration layer of gamma-irradiated DNA. Radiat. Res. 140, 123-129 (1994).
26. · formation. Radiat. Res. 145, 673-680 (1996).
27. M. E. Malone, P. M. Cullis, M. C. R. Symons and A. W. Parker, Biphotonic photoionization of cytosine and its derivatives with UV radiation at 248 nm: An EPR study in low-temperature perchlorate glasses. J. Phys. Chem. 99, 9299-9308 (1995).
28. 84): Evidence for damage to the deoxyribose phosphate backbone. Radiat. Res. 146, 361-368 (1996).
29. D. Sy, C. Savoye, M. Begusova, V. Michalik, M. Charlier and M. Spothcim-Maurizot, Sequence-dependent variations of DNA structure modulate radiation-induced strand breakage. Int. J. Radiat. Biol. 72, 147-155 (1997).
30. B. Balasubramanian, W. K. Pogozelski and T. D. Tullius, DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Proc. Natl. Acad. Sci. USA 95, 9738-9743 (1998).
31. M. T. Milano and W. A. Bernhard., The effect of packing and conformation on free radical yields in films of variably hydrated DNA. Radiat. Res. 151, 139-149 (1999).
32. W. A. Bernhard, Solid-state radiation of DNA: The bases. Adv. Radiat. Biol. 9, 199-280 (1981).
33. L. Kar and W. A. Bernhard, Electron gain and electron loss radicals stabilized on the purine and pyrimidine of cocrystal exhibiting base-base interstacking: ESR-ENDOR of X-irradiated adenosine:5-bromouracil. Radiat. Res. 93, 232-253 (1983).
34. D. M. Close, Where are the sugar radicals in irradiated DNA? Radiat. Res. 147, 663-673 (1997).
35. B. Weiland and J. Huttermann, Free radicals from X-irradiated 'dry' and hydrated lyophilized DNA as studied by electron spin resonance spectroscopy: analysis of spectral components between 77K and room temperature. Int. J. Radiat. Biol. 74, 341-358 (1998).
36. B. Weiland and J. Huttermann, Free radicals from lyophilized 'dry' DNA bombarded with heavy-ions as studied by electron spin resonance spectroscopy. Int. J. Radiat. Biol. 75, 1169-1175 (1999).
37. J. R. Milligan, J. A. Aguilera and J. F. Ward, Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution. Radiat. Res. 133, 151-157 (1993).