Power comparison of regression methods to test quantitative traits for association and linkage

Genetic Epidemiology

Volumn 18, Issue 4, 2000, Pages 322-330

  Zhu, Xiaofeng ^a,b   Elston, Robert C ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Association; Likelihood ratio test; Linkage; Linkage disequilibrium; Transmission disequilibrium test

Indexed keywords

ARTICLE; DISEASE ASSOCIATION; FOUNDER EFFECT; GENE LINKAGE DISEQUILIBRIUM; GENETIC MODEL; QUANTITATIVE TRAIT; REGRESSION ANALYSIS;

EID: 0034108374     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2272(200004)18:4<322::aid-gepi5>3.0.co;2-%23     Document Type: Article

References (18)

1. Allison DB. 1997. Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690.
2. Breslow NE, Clayton DG. 1993. Approximate inference in generalized linear mixed models. J Am Statist Assoc 88: 9-25.
3. Cleves MA, Olson JM, Jacobs KB. 1997. Exact transmission-disequilibrium tests with multiallelic markers. Genet Epidemiol 14:337-347.
4. Drum, ML, McCullagh P. 1993. REML estimation with exact covariance in the logistic mixed models. Biometrics 49:677-689.
5. Elston RC, Stewart J. 1971. A general model for the genetic analysis of pedigree data. Hum Hered 21:523-542.
6. Elston RC, George VT, Severtson F. 1992. The Elston-Stewart algorithm for continuous genotypes and environmental factors. Hum Hered 42:16-27.
7. George VT, Elston RC. 1987. Testing the association between polymorphic genetic markers and quantitative traits in pedigrees. Genet Epidemiol 4:193-201.
8. George VT, Tiwari HK, Zhu X, Elston RC. 1999. A test of transmission/disequilibrium for quantitative traits in pedigree data, by using multiple regression. Am J Hum Genet 65:236-245.
9. Jiang J. 1998. Consistent estimators in generalized linear mixed models. J Am Statist Assoc 93: 720-729.
10. Knapp M. 1999. The transmission/disequilibrium test (TDT) and parental genotype reconstruction: The reconstruction-combined transmission/disequilibrium test. Am J Hum Genet 64:861-870.
11. Martin ER, Kaplan NL, Weir BS. 1997. Tests for linkage and association in nuclear families. Am J Hum Genet 61:439-448.
12. Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
13. S.A.G.E. 1998. Statistical Analysis for Genetic Epidemiology. Software package available from the Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
14. Schaid DJ. 1996. General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449.
15. Spielman RS, Ewens WJ. 1998. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 62:450-458.
16. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
17. Zhu X. 1999. Associations between traits and genetic markers. PhD thesis, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.
18. Zhu X, Elston RC. 2000. Transmission/disequilibrium test for quantitative traits. Genet Epidemiol (in press).