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8 DeStefano AL, Baldwin CT, Burzstyn M, Gavras I, Hande DE, Joost O, et al. Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q. Am J Hum Genet 1998; 63:1425-1430. An important mapping study of a new 'low blood pressure' locus.
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11 Baima J, Nicolaou M, Schwartz F, DeStefano AL, Manolis A, Gavras I, et al. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension 1999; 34:4-7. If rat studies will provide any useful information, synteny must be shown. This human linkage study succeeded.
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Mapping of a blood pressure quantitative trait locus to chromosome 15q in a Chinese population
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An extreme-sib-pair genome scan for genes regulating blood pressure
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13 Xu X, Rogus JJ, Terwedow HA, Yang J, Wang Z, Chen C, et al. An extreme-sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet 1999; 64:1694-1701.
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Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure
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Wong, Z.Y.1
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Quantitative trait loci for blood pressure exist near the igf-1, the liddle syndrome, the angiotensin II-receptor gene and the renin loci in man
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16 Nagy Z, Busjahn A, Bhring S, Faulhaber HD, Gohlke HR, Knoblauch H, et al. Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man. J Am Soc Nephrol 1999; 10:1709-1716. This study shows that twin genetics is highly useful for finding blood pressure and other QTL.
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J Am Soc Nephrol
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Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins
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17 Busjahn A, Aydin A, von Treuenfels N, Faulhaber HD, Gohlke HR, Knoblauch H, et al. Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins. J Hypertens 1999; 17:1437-1441.
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Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure
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18 Takami S, Wong ZYH, Stebbing M, Harrap SB. Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure. J Hypertens 1999; 17:1431-1436.
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Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
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19 Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 1999; 21:76-83. High tech approach enabled the rat doctors to finally clone a gene. The relevance to hypertension remains to be proved.
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Pravenec, M.1
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Freely associating
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21 Anonymous. Freely associating. Nat Genet 1999; 22: 1-2. All investigators involved in association studies must read this editorial.
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Context-dependent assocation of the ACE I/D polymorphism with blood pressure
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22 Turner ST, Boerwinkle E, Sing CF. Context-dependent assocation of the ACE I/D polymorphism with blood pressure. Hypertension 1999; 34:773-778.
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Turner, S.T.1
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Sequence variation in the human angiotensin converting enzyme
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23 Rieder MJ, Taylor SL, Clark AG, Nickerson DA. Sequence variation in the human angiotensin converting enzyme. Nat Genet 1999; 22:59-62. This study of the ACE gene shows how variable genes are in the normal population.
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Rieder, M.J.1
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24
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A 6g variant of angiotensinogen gene and aldosterone levels in hypertensives
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24 Fardella C, Zamorano P, Mosso L, Gomez L, Pinto M, Soto J, et al. A 6G variant of angiotensinogen gene and aldosterone levels in hypertensives. Hypertension 1999; 34:779-781.
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Fardella, C.1
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Angiotensinogen M235t variant and salt sensitivity in young normotensive Caucasians
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25 Schorr U, Blaschke K, Beige J, Distler A, Sharma AM. Angiotensinogen M235T variant and salt sensitivity in young normotensive caucasians. J Hypertens 1999; 17:475-479.
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Schorr, U.1
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26 Kato N, Sugiyama T, Morita H, Kurihara H, Yamori Y, Yazaki Y. Angiotensinogen gene and essential hypertension in the Japanese: extensive association study and meta-analysis on six reported studies. J Hypertens 1999; 17:757-763. A careful association study and subsequent meta-analysis of angiotensinogen in Japanese patients.
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Kato, N.1
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Katsuya, T.1
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Seven lessons from two candidate genes in human essential hypertension: Angiotensinogen and epithelial sodium channel
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28 Corvol P, Persu A, Gimenez-Roqueplo A-P, Jeunemaitre X. Seven lessons from two candidate genes in human essential hypertension: angiotensinogen and epithelial sodium channel. Hypertension 1999; 33:1324-1331. Worthwhile lessons from masters in the field.
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Corvol, P.1
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Functional analysis of a mutation occurring between the two in-frame aug codons of human angiotensinogen
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29 Nakajima T, Cheng T, Rohrwasser A, Bloem LJ, Pratt JH, Inoue I, Lalouel JM. Functional analysis of a mutation occurring between the two in-frame AUG codons of human angiotensinogen. J Biol Chem 1999; 274:35749-35755.
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Nakajima, T.1
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30 Ambrosius WT, Bloem LJ, Zhou L, Rebhun JF, Snyder PM, Wagner MA, et al. Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension 1999; 34:631-637.
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Ambrosius, W.T.1
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Polymorphisms of the g subunit of the epithelial na+ channel in essential hypertension
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31 Persu A, Coscoy S, Houot A-M, Corvol P, Barbry P, Jeunemaitre X. Polymorphisms of the g subunit of the epithelial Na+ channel in essential hypertension. J Hypertens 1999; 17:639-645.
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32 Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, et al. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle¥s syndrome. J Clin Invest 1999; 103:667-673.
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33 Ferrandi M, Salardi S, Tripodi G, Barassi P, Rivera R, Manunta P, et al. Evidence for an interaction between adducin and the Na+-K+-ATPase: relation to genetic hypertension. Am J Physiol 1999; 277:H1338-HZ1349.
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34
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The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study
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34 Glorioso N, Manunta P, Filigheddu F, Troffa C, Stella P, Barlassina C, et al. The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study. Hypertension 1999; 34:649-654. A double association study at two different locations.
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Glorioso, N.1
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11 b-hydroxysteroid dehydrogenase in cultured human vascular cells
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35 Hatakayama H, Inaba S, Miyamori I. 11 b-hydroxysteroid dehydrogenase in cultured human vascular cells. Hypertension 1999; 33:1179-1184.
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Molecular basis of human salt sensitivity: The role of the 11b-hydroxysteroid dehydrogenase type 2
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36 Lovati E, Ferrari P, Dick B, Jostarndt K, Frey BM, Frey FJ, et al. Molecular basis of human salt sensitivity: the role of the 11b-hydroxysteroid dehydrogenase type 2. J Clin Endocrinol Metabol 1999; 84:3745-3749. An important intermediary phenotype is elucidated in this study.
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Lovati, E.1
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37 Lin RCY, William YS, Morris BJ. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. Hypertension 1999; 34:1186-1192.
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Lin, R.C.Y.1
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G protein beta3 subunit 825t allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation
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39 Baumgart D, Naber C, Haude M, Oldenburg O, Erbel R, Heusch G, Siffert W. G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. Circ Res 1999; 85:965-969. Highly interesting functional data in this 'bottom up' association study.
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Circ Res
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Baumgart, D.1
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Worldwide ethnic distribution of the g protein beta3 subunit 825t allele and its association with obesity in Caucasian, Chinese, and black African individuals
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40 Siffert W, Forster P, Jockel KH, Mvere DA, Brinkmann B, Naber C, et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999; 10:1921-1930.
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85T allele of the G-protein b3 subunit (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension
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41 Jacobi J, Hilgers KF, Schlaich MP, Siffert W, Schmieder RE. 85T allele of the G-protein b3 subunit (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. J Hypertens 1999; 17:1457-1462.
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Association between the C825t polymorphism of the g protein b3-subunit gene and hypertension in blacks
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42 Dong Y, Zhu H, Sagnella GA, Carter ND, Cook DG, Cappuccio FP. Association between the C825T polymorphism of the G protein B3-subunit gene and hypertension in blacks. Hypertension 1999; 34:1193-1196. Most convincing association study to date on the beta3 subunit gene.
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Dong, Y.1
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Association of the gsa gene with essential hypertension and response to b-blockade
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43 Jia H, Hingorani AD, Sharma P, Hopper R, Dickerson C, Trutwein D, et al. Association of the Gsa gene with essential hypertension and response to b-blockade. Hypertension 1999; 34:8-14.
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Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension
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44 Kato N, Sugiyama T, Morita H, Nabika T, Kurihara H, Yamori Y, Yazaki Y. Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension. Hypertension 1999; 33:933-936.
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Different frequencies of inducible nitric oxide synthase genotypes in older hypertensives
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