Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue

Journal of Applied Physiology

Volumn 85, Issue 1, 1998, Pages 181-188

  Millet, L ^a   Barbe, P ^a   Lafontan, M ^a   Berlan, M ^a   Galitzky, J ^a  

^a INSERM   (France)

Author keywords

Active tilt; Fat deposit; In situ effect; Men; Microdialysis; Women

Indexed keywords

ADRENALIN; CATECHOLAMINE; FATTY ACID; GLYCEROL; ISOPRENALINE; LIPID; NORADRENALIN;

ABDOMEN; ADIPOSE TISSUE BLOOD FLOW; ADRENERGIC SYSTEM; ADULT; ARTICLE; BODY FAT; CATECHOLAMINERGIC SYSTEM; CLINICAL PROTOCOL; CONTROLLED STUDY; FEMALE; FEMUR; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIPOLYSIS; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; TILTING;

EID: 0031877034     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.1.181     Document Type: Article

References (23)

1. Arner, P., and J. Bolinder. Microdialysis of adipose tissue. J. Intern. Med. 230: 381-386, 1991.
2. Arner, P., E. Kriegholm, and P. Engfeldt. In vivo interactions between beta1- and beta2-adrenoceptors regulate catecholamine tachyphylaxia in human adipose tissue. J. Pharmacol. Exp. Ther. 252:317-322, 1991.
3. Arner, P., E. Kriegholm, P. Engfeldt, and J. Bolinder. Adrenergic regulation of lipolysis in situ at rest and during exercise. J. Clin. Invest. 85: 893-898, 1990.
4. Barbe, P., L. Millet, J. Galitzky, M. Lafontan, and M. Berlan. In situ assessment of the role of the β1-, β2- and β3-adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue. Br. J. Pharmacol. 117: 907-913, 1996.
5. Barbe, P., V. Stich, J. Galitzky, M. Kunesova, M. Hainer, M. Lafontan, and M. Berlan. In vivo increase in the β-adrenergic lipolytic response in subcutaneous adipose tissue of obese subjects submitted to a hypocaloric diet. J. Clin. Endocrinol. Metab. 82: 63-69, 1997.
6. Bernt, E., and I. Gutmann. Ethanol determination with alcohol dehydrogenase and NAD. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1499-1505.
7. Bradley, D. C., and H. R. Kaslow. Radiometric assays for glycerol, glucose and glycogen. Anal. Biochem. 180: 11-16, 1989.
8. Damase-Michel, C., G. Tavernier, P. Giraud, J.-L. Montastruc, P. Montastruc, and M.-A. Tran. Effects of clonidine, dihydralazine and splanchnic nerve stimulation on the release of neuropeptide Y, MET-enkephalin and catecholamines from dog adrenal medulla. Naunyn Schmiedebergs Arch. Pharmacol. 348: 379-384, 1993.
9. Enocksson, S., J. Nordenström, J. Bounder, and P. Arner. Influence of local blood flow on glycerol levels in human adipose tissue. Int. J. Obes. 19: 350-354, 1995.
10. Fellander, G., B. Linde, and J. Bolinder. Evaluation of the microdialysis ethanol technique for monitoring of subcutaneous adipose tissue blood flow in humans. Int. J. Obes. 20: 220-226, 1996.
11. Galitzky, J., M. Lafontan, J. Nordenström, and P. Arner. Role of vascular alpha2-adrenoceptors in regulating lipid mobilization from human adipose tissue. J. Clin. Invest. 91: 1997-2003, 1993.
12. Hagström-Toft, E., P. Arner, H. Wahrenberg, A. Wennlund, U. Ungerstedt, and J. Bolinder. Adrenergic regulation of human adipose tissue metabolism in situ during mental stress. J. Clin. Endocrinol. Metab. 76: 392-398, 1993.
13. Hickner, R. C., H. Rosdahl, I. Borg, U. Ungerstedt, L. Jorfeldt, and J. Henriksson. Ethanol may be used with the microdialysis technique to monitor blood flow changes in skeletal muscle: dialysate glucose concentration is blood flow-dependent. Acta Physiol. Scand. 143: 355-356, 1991.
14. Jansson, P.-A., A. Larsson, U. Smith, and P. Lönnroth. Glycerol production in subcutaneous adipose tissue of lean and obese humans. J. Clin. Invest. 89: 1610-1617, 1992.
15. Jansson, P.-A., U. Smith, and P. Lönnroth. Interstitial glycerol concentration measured by microdialysis in two subcutaneous regions in humans. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E918-E922, 1990.
16. Lafontan, M., and P. Arner. Application of in situ microdialysis to measure metabolic and vascular responses in adipose tissue. Trends Pharmacol. Sci. 17: 309-313, 1996.
17. Lafontan, M., and M. Berlan. Fat cell adrenergic receptors and the control of white and brown fat cell function. J. Lipid Res. 34: 1057-1091, 1993.
18. Maggs, D. G., R. Jacob, F. Rife, R. Lange, P. Leone, M. J. During, W. V. Tamborlane, and R. S. Sherwin. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. J. Clin. Invest. 96: 370-377, 1995.
19. Mauriège, P., J. P. Després, D. Prud'homme, M. C. Pouliot, M. Marcotte, A. Tremblay, and C. Bouchard. Regional variation in adipose tissue lipolysis in lean and obese men. J. Lipid Res. 32: 1625-1633, 1991.
20. Mauriège, P., J. Galitzky, M. Berlan, and M. Lafontan. Heterogeneous distribution of beta- and alpha2-adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur. J. Clin. Invest. 17: 156-165, 1987.
21. Mauriège, P., G. D. Pergola, M. Berlan, and M. Lafontan. Human fat cell beta-adrenergic receptors: beta agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective betal-antagonists. J. Lipid Res. 29: 587-601, 1988.
22. Mauriège, P., D. Prud'homme, S. Lemieux, A. Tremblay, and J. P. Despres. Regional differences in adipose tissue lipolysis from lean and obese women: existence of postreceptor alterations. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E341-E350, 1995.
23. Tavernier, G., P. Barbe, J. Galitzky, M. Berlan, D. Caput, M. Lafontan, and D. Langin. Expression of β3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes. J. Lipid Res. 37: 87-97, 1996.