Clinically available NMDA receptor antagonists memantine and dextromethorphan reverse existing tolerance to the antinociceptive effects of morphine in mice

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 4, 2000, Pages 425-432

  Popik, Piotr ^a   Kozela, Ewa ^a   Danysz, Wojciech ^b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Analgesia; Antinociception; Dextromethorphan; Memantine; Morphine; MRZ 2 579; NMDA antagonist; Tolerance

Indexed keywords

DEXTROMETHORPHAN; MEMANTINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NARCOTIC ANALGESIC AGENT;

ANALGESIA; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CHRONIC PAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG TOLERANCE; MALE; MOUSE; NONHUMAN; PAIN; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; CYCLOPENTANES; DEXTROMETHORPHAN; DRUG TOLERANCE; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MEMANTINE; MICE; MORPHINE; RECEPTORS, N-METHYL-D-ASPARTATE; TAIL;

EID: 0034098620     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900205     Document Type: Article

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