Prolongation of morphine analgesia by competitive NMDA receptor antagonist d-CPPene (SDZ EAA 494) in rats

European Journal of Pharmacology

Volumn 351, Issue 3, 1998, Pages 299-305

  Bespalov, Anton ^a   Kudryashova, Marina ^a   Zvartau, Edwin ^a  

^a Valdman Institute of Pharmacology   (Russian Federation)

Author keywords

Analgesia; D CPPene ((3 (2 carboxypiperazin 4 yl) 1 propenyl 1 phosphonic acid); Morphine; NMDA receptor antagonist; Plasma concentration; Rat; SDZ EAA 494; Time course

Indexed keywords

4 (3 PHOSPHONOALLYL) 2 PIPERAZINECARBOXYLIC ACID; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ESCAPE REACTION; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MORPHINE; PAIN MEASUREMENT; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TAIL; TIME FACTORS;

EID: 0031876628     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00324-0     Document Type: Article

References (36)

1. Aebischer, B., Frey, P., Härter, H.-P., Herrling, P.L., Müller, W., Olverman, H.J., Watkins, J.C., 1989. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphono-propyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4(3-phosphono-prop-2-enyl)piperazine-2-carboxylic acid (CPPene). Helv. Chim. Acta 72, 1043-1051.
2. Ben-Eliyahu, S., Marek, P., Vaccarino, A.L., Mogil, J.S., Sternberg, W.F., Liebeskind, J.C., 1992. The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Res. 575, 304-308.
3. Bernardi, M., Bertolini, A., Szczawinska, K., Genedani, S., 1996. Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine, in mice. Eur. J. Pharmacol. 298, 51-55.
4. Bespalov, A.Y., 1994. Comparative study on analgesic and reinforcing effects of EAA antagonists, Pavlov Medical University Press, St.Petersburg, p. 216.
5. Bespalov, A.Y., Dumpis, M.A., Piotrovsky, L.B., Zvartau, E.E., 1994. Tolerance to opiate analgesia: complex effect of excitatory amino acid receptors antagonists. Bull. Exp. Biol. Med. 5, 494-496.
6. Bhargava, H.N., 1997. Enhancement of morphine actions in morphine3 naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor. Gen. Pharmacol. 28, 61-64.
7. Bilsky, E.J., Inturrisi, C.E., Sadee, W., Hruby, V.J., Porreca, F., 1996. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice. Pain 68, 229-237.
8. Bobelis, D.J., Balster, R.L., 1993. Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist. J. Pharmacol. Exp. Ther. 264, 845-853.
9. Contreras, E., Tamayo, L., 1985. Effects of ethylenediamine on morphine analgesia and tolerance-dependence in mice. Gen. Pharmacol. 16, 529-531.
10. Contreras, E., Tamayo, L., Amigo, M., 1988. Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance. Eur. J. Pharmacol. 148, 463-466.
11. Elliott, K., Minami, N., Kolesnikov, Y.A., Pasternak, G.W., Inturrisi, C.E., 1994. The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 56, 69-75.
12. Danysz, W., Zajaczkowski, W., Parsons, C.G., 1995. Modulation of learning processes by ionotropic glutamate receptor ligands. Behav. Pharmacol. 6, 455-474.
13. Grass, S., Hoffmann, O., Xu, X.J., Wiesenfeld-Hallin, Z., 1996. N-methyl-D-aspartate receptor antagonists potentiate morphine's antinociceptive effect in the rat. Acta Physiol. Scand. 158, 269-273.
14. Herman, B.H., Vocci, F., Bridge, P., 1995. The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Neuropsychopharmacology 13, 269-293.
15. Kissin, I., Brown, P.T., Robinson, C.A., Bradley Jr., E.L., 1991. Acute tolerance in morphine analgesia: continuous infusion and single injection in rats. Anesthesiology 74, 166-171.
16. Kolesnikov, Y.A., Ferkany, J., Pasternak, G.W., 1993. Blockade of mu and kappa 1 opioid analgesic tolerance by NPC17742, a novel NMDA antagonist. Life Sci. 53, 1489-1494.
17. Kolesnikov, Y.A., Maccechini, M.L., Pasternak, G.W., 1994. 1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance. Life Sci. 55, 1393-1398.
18. Lipa, S.M., Kavaliers, M., 1990. Sex differences in the inhibitory effects of the NMDA antagonist, MK-801, on morphine and stress-induced analgesia. Brain Res. Bull. 24, 627-630.
19. Lowe, D.A., Emre, M., Frey, P., Kelly, P.H., Malanowski, J., McAllister, K.H., Neijt, H.C., Rudeberg, C., Urwyler, S., White, T.G., 1994. The pharmacology of SDZ EAA 494, a competitive NMDA antagonist. Neurochem. Int. 25, 583-600.
20. Lutfy, K., Hurlbut, D.E., Weber, E., 1993. Blockade of morphine-induced analgesia and tolerance in mice by MK-801. Brain Res. 616, 83-88.
21. Marek, P., Ben Eliyahu, S., Gold, M., Liebeskind, J.C., 1991a. Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res. 547, 77-81.
22. Marek, P., Page, G.G., Ben-Eliyahu, S., Liebeskind, J.C., 1991b. N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia: I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice. Brain Res. 551, 293-296.
23. McAllister, K., 1993. Antagonism of non-NMDA receptors inhibits handling-induced, strychnine-potentiated convulsions. Eur. J. Pharmacol. 231, 309-312.
24. Santillan, R., Maestre, J.M., Hurle, M.A., Florez, J., 1994. Enhancement of opiate analgesia by nimodipine in cancer patients treated with morphine: a preliminary report. Pain 58, 129-132.
25. Saucier, D.M., Kavaliers, M., 1994. Antagonistic effects of the selective, competitive N-methyl- D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice. Brain Res. 637, 292-296.
26. Shoaib, M., Benwell, M.E.M., Akbar, M.T., Stolerman, I.P., Balfour, D.J.K., 1994. Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists. Br. J. Pharmacol. 111, 1073-1080.
27. Tebbett, I.R., 1987. Rapid extraction of codeine and morphine in whole blood for HPLC analysis. Chromatographia 23, 377-378.
28. Tiseo, P.J., Inturrisi, C.E., 1993. Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614. J. Pharmacol. Exp. Ther. 264, 1090-1096.
29. Trujillo, K.A., Akil, H., 1991a. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251, 85-87.
30. Trujillo, K.A., Akil, H., 1991b. The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality. Pharmacol. Biochem. Behav. 38, 673-675.
31. Vaccarino, A.L., Marek, P., Sternberg, W., Liebeskind, J.C., 1992. NMDA receptor antagonist MK-801 blocks non-opioid stress-induced analgesia in the formalin test. Pain 50, 119-123.
32. Van Amsterdam, C., Lemaire, M., 1997. Pharmacokinetic profile of SDZ EAA 494 in blood, brain and CSF using microdialysis. Eur. J. Pharm. Sci. 5, 109-116.
33. Verbitskaja, E.V., Kudryashova, M.F., 1997. Ritanserin prolongs the analgesic effect of morphine and delays the development of tolerance. Exp. Clin. Pharmacol. 60, 10-13.
34. Xu, X.J., Wiesenfeld-Hallin, Z., Hughes, J., Horwell, D.C., Hokfelt, T., 1992. CI988, a selective antagonist of cholecystokinin B receptors, prevents morphine tolerance in the rat. Br. J. Pharmacol. 105, 591-596.
35. Xu, X.J., Hoffmann, O., Wiesenfeld-Hallin, Z., 1996. L-740,093, a new antagonist of the CCK-B receptor, potentiates the antinociceptive effect of morphine: electrophysiological and behavioural studies. Neuropeptides 30, 203-206.
36. Zarrindast, M.R., Sajedian, M., Rezayat, M., Ghazi-Khansari, M., 1995. Effects of 5-HT receptor antagonists on morphine-induced tolerance in mice. Eur. J. Pharmacol. 273, 203-207.