Is there such a thing as << intrinsic >> asthma?;L'asthme << intrinseque >> existe-t-il?

Revue des Maladies Respiratoires

Volumn 17, Issue 1 BIS, 2000, Pages 245-254

  Humbert, M ^a  

^a Institut Paris Sud sur les Cytokines   (France)

Author keywords

Allergy; Asthma; Chemokines; Cytokines; Immunoglobulin E

Indexed keywords

ACETYLSALICYLIC ACID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; CHEMOKINE; CYTOKINE;

ALLERGIC ASTHMA; ASTHMA; CYTOKINE RELEASE; HUMAN; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE ACTIVATION; MACROPHAGE; MAST CELL; NOSE POLYP; REVIEW; BIOSYNTHESIS; CLASSIFICATION; IMMUNOLOGY; LUNG; PHYSIOLOGY;

ASTHMA; CHEMOKINES; CYTOKINES; HUMANS; LUNG; RECEPTORS, IGE;

EID: 0034095986     PISSN: 07618425     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. RACKEMAN FM : A working classification of asthma. Am J Med 1947;3:601-6.
2. VERVLOET D, CHARPIN D : Intrinsic asthma. In Holgate ST, Lockhart A, Marsh DG (eds). Genetics of asthma. Blackwell Scientific Publications, Oxford 1994;93-101.
3. BENTLEY AM, MENZ G, STORZ C et al. : Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146:500-6.4.
4. HUMBERT M, GRANT JA, TABORDA-BARATA L et al. : High affinity IgE receptor (FcεRI)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am J Respir Crit Care Med 1996;153:1931-7.
5. GODARD P, BOUSQUET J, MICHEL FB : Extrinsic and intrinsic asthma: still a matter for debate ? Clin Asthma Rev 1997;1:19-22.
6. WÜRTHRICH B, SCHINDLER C, LEUENBERGER P, ACKERMANN-LIEBRICH U : Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Int Arch Allergy Immunol 1995;106:149-56.
7. PIRSON F, CHARPIN D, SANSONETTI M et al. : Is intrinsic asthma a hereditary disease. Allergy 1991;46:367-71.
8. PEPYS J. ATOPY : In : Gill PGH, Coombs RRA, Cochmann PJ (eds). Clinical aspects of immunology, 3rd edn. Blackwell Science, Oxford 1975;877-902.
9. CARTIER A, THOMPSON NC, FRITH PA, ROBERTS R, HARGREAVE FE : Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway calibre. J Allergy Clin Immunol 1982;70:170-7.
10. DORWARD AJ, COLLOF MJ, MACKAY NS, MCSHARRY C, THOMPSON NC : Effect of house dust mite avoidance measures on adult atopic asthma. Thorax 1988;43:95-105.
11. CUSTOVIC A, SIMPSON A, CHAPMAN MD, WOODCOCK A : Allergen avoidance in the treatment of asthma and atopic disorders. Thorax 1998;53:63-72.
12. BOUSQUET J, MICHEL F : Specific immunotherapy in asthma: is it effective? J Allergy Clin Immunol 1994;94:1-11.
13. LASSALLE P, DELNESTE Y, GOSSET P, GRAS-MASSE, WALLAERT B, TONNEL A-B : T and B cell immune response to a 55-kDa endothelial cell-derived antigen in severe asthma. Eur J Immunol 1993;23:796-803.
14. HIDE M, FRANCIS DM, GRATTAN CEH, HAKIMI J, KOCHAN JP, GREAVES MW : Autoantibodies against the high affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 1993;328:1599-604.
15. WELLIVER RC, WONG DT, SUN M, MIDDELTON JR E, VAUGHAN RS, OGRA PL : The development of respiratory syncitial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. N Engl J Med 1981;305:841-6.
16. BOUSQUET J, CHANEZ P, LACOSTE J-Y et al. : Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
17. DJUKANOVIC R, WILSON JW, BRITTEN KM : Mucosal inflammation in asthma. Am Rev Respir Dis 1990;142:434-57.
18. CORRIGAN CJ, KAY AB : T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992;13:501-7.
19. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
20. YING S, DURHAM SR, CORRIGAN C, HAMID Q, KAY AB : Phenotype of cells expressing mRNA for TH2 type (IL-4 and IL-5) and TH1 type (IL-2 and IFN-gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects. Am J Resp Cell Mol Biol 1995;12:477-87.
21. HUMBERT M : Pro-eosinophilic cytokines in asthma. Clin Exp Allergy 1996;26:123-7.
22. BURROWS B, MARTINEZ FD, HALONEN M, BARBEE RA, CLINE MG : Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271-7.
23. SEARS MR, BURROWS B, FLANNERY EM, HERBISON GP, HEWITT CJ, HOLDAWAY MD : Relation between airway hyperresponsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991;325:1067-71.
24. WALKER C, VIRCHOW JR C, BRUINJZEEL PLB, BLASER K : T cell subsets and their soluble product regulate eosinophilia in allergic and nonallergic asthma. J Immunol 1991;146:1829-35.
25. WALKER C, BODE E, BOER L, HANSEL TT, BLASER K, VIRCHOW JR JC : Allergic and non-allergic asthmatics have distinct patterns of T cell activation and cytokine production in peripheral blood and broncho-alveolar lavage. Am Rev Respir Dis 1992;146:109-15.
26. KROEGEL C, JÄGER L, WALKER C : Is there a place for intrinsic asthma as a distinct immunopathological entity? Eur Respir J 1997;10:513-5.
27. LOPEZ AF, SANDERSON CJ, GAMBLE JR, CAMPBELL HD, YOUNG IG, VADAS MA : Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 1988;167:219-24.
28. WALSH GM, HARTNELL A, WARDLAW AJ, KURIHARA K, SANDERSON CJ, KAY AB : IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 1990;71:258-65.
29. DEL PRETE GF, MAGGI E, PARRONCHI P : IL-4 is an essential co-factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
30. HUMBERT M, DURHAM SR, YING S et al. : IL-4 and IL-5 mRNA and protein in bronchial biopsies from atopic and non-atopic asthmatics: evidence against «intrinsic »asthma being a distinct immunopathological entity. Am J Respir Crit Care Med 1996;154:1497-504.
31. HUMBERT M, YING S, CORRIGAN C et al. : Bronchial mucosal gene expression of the genes encoding CC chemokines RANTES and MCP-3 in symptomatic atopic and non-atopic asthmatics: relationship to the eosinophil-active cytokines IL-5, GM-CSF and IL-3. Am J Respir Cell Mol Biol 1997;16:1-8.
32. + T cells, eosinophils and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics. J Immunol 1997;158:3539-44.
33. YASRUEL Z, HUMBERT M, KOTSIMBOS ATC et al. : Expression of membrane-bound and soluble interleukin-5 alpha receptor mRNA in the bronchial mucosa of atopic and non-atopic asthmatics. Am J Respir Crit Care Med 1997;155:1413-8.
34. HUMBERT M, DURHAM SR, KIMMITT P et al. : Elevated expression of mRNA encoding interleukin-13 in the bronchial mucosa of atopic and non-atopic asthmatics. J Allergy Clin Immunology 1997;99:657-65.
35. KOTSIMBOS ATC, HUMBERT M, MINSHALL E et al. : Upregulation of αGM-CSF-receptor in non-atopic but not in atopic asthma. J Allergy Clin Immunology 1997;99:666-72.
36. KOTSIMBOS TC, GHAFFAR O, MINSHALL EM et al. : Expression of interleukin-4 receptor α-subunit is increased in bronchial biopsies from atopic and non-atopic asthmatics. J Allergy Clin Immunol 1998;sous presse.
37. HUMBERT M, ROBINSON DS, ASSOUFT B, KAY AB, DURHAM SR : Safety of fibreoptic bronchoscopy in asthmatics and control subjects and effect on asthma control over two weeks. Thorax 1996;51:664-9.
38. HUMBERT M, CORRIGAN CJ, DURHAM SR, KIMMITT P, TILL SJ, KAY AB : Relationship between bronchial mucosal interleukin-4 and interleukin-5 mRNA expression and disease severity in atopic asthma. Am J Respir Crit Care Med 1997;156:704-8.
39. POWELL N, HUMBERT M, DURHAM SR, ASSOUFI B, KAY AB, CORRIGAN C : Increased expression of mRNA encoding RANTES and MCP-3 in the bronchial mucosa in atopic asthma. Eur Respir J 1996;9:2454-60.
40. TAVERNIER J, DEVOS R, CORNELIS S et al. : A human high affinity interleukin-5 (IL-5) receptor is composed of an IL-5 specific α chain and a β chain shared with the receptor for GM-CSF. Cell 1991;66:1175-84.
41. TAVERNIER J, TUYPENS T, PLAETINCK G, VERHEE A, FIERS W, DEVOS D : Molecular basis of the mebrane-anchored and two soluble isoforms of the human interleukin 5 receptor a subunit. Proc Natl Acad Sci USA 1992;89:7041-5.
42. NAKAGAWA Y, KOSUGI H, MIYAJIMA A, ARAI K, YOKOTA T : Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem 1994;269:10905-12.
43. CALLARD RE, MATTHEWS DJ, HIBBERT L: IL-4 and IL-13 receptors: are they one and the same? Immunol Today 1996; 17:108-10.
44. DURHAM SR, GOULD HJ, THIENES CP et al. : Expression of ε germ-line gene transcripts and mRNA for the ε heavy chain of IgE in nasal B cells and the effects of topical steroids. Eur J Immunol 1997;27:2899-906.
45. DURHAM SR, YING S, MENG Q, HUMBERT M, GOULD HJ, KAY AB : Local expression of ε germ-line gene transcripts (Iε) and mRNA for the ε heavy chain of IgE (Cε) in the bronchial mucosa in atopic and non-atopic asthma. J Allergy Clin Immunol 1998;101:S162 (Abstract 668).
46. SPRINGER TA : Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-14.
47. SPRINGER TA : Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-14.
48. DRAZEN JM, ARM JP, AUSTEN KP : Sorting out the cytokines of asthma. J Exp Med 1996;183:1-5.
49. BAGGIOLINI M, DAHINDEN CA : CC chemokines in allergic inflammation. Immunol Today 1994;15:127-33.
50. SCHALL TJ, BACON KB : Chemokines, leukocyte trafficking, and inflammation. Cur Opin Immunol 1994;6:865-73.
51. MOTOJIMA S, FRIGAS E, LOEGERING DA, GLEICH GJ : Toxicity of eosinophil cationic protein for guinea pig tracheal epithelium. Am Rev Respir Dis 1989;139:801-5.
52. GUNDEL RH, LETTS LG, GLEICH GJ : Human eosinophil major basic protein induces airway constriction and airway responsiveness in primates. J Clin Invest 1991;87:1470-3.
53. YING S, TABORDA-BARATA L, MENG Q, HUMBERT M, KAY AB : The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T-cell, and macrophage recruitment. J Exp Med 1995;181:2153-9.
54. JOSE PJ, GRIFFITHS-JOHNSON DA, COLLINS PD et al. : Eotaxin: a potent eosinophil chemoattractant detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994:179:881-7.
55. GARCIA-ZEPEDA EA, ROTHENBERG ME, OWNBEY RT, CELESTIN J, LEDER P, LUSTER AD : Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Medicine 1996;2:449-56.
56. YING S, ROBINSON DS, MENG Q et al. : Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma: association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 1997;27:3507-16.
57. MINTY A, CHALON P, DEROCQ JM et al. : Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993;362:248-50.
58. PLATTS-MILLS TAE, CHAPMAN MD, POLLART SQUILLACE S, SPORIK RB, CALL RS, HEYMANN PW : The role of allergens. In : Asthma: Physiology, Immunopharmacology, and treatment. Holgate ST, Austen KF, Lichtenstein LM, Kay AB, Ed. San Diego. Academic Press 1993:27-39.
59. CHANG-YEUNG M, MALO J-M : Occupational asthma. N Engl J Med 1995;333:107-12.
60. POULTER LW, JANOSSY G, POWER C, SREENAN S, BURKE C : Immunological/physiological relationships in asthma: potential regulation by lung macrophages. Immunol Today 1994;15:258-61.
61. ALEXANDER AG, BARNES NC, KAY AB : Trial of ciclosporin on corticosteroid-dependent asthma. Lancet 1992;339:324-8.
62. LOCK S, KAY AB, BARNES NC : Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care Med 1996;153:509-14.
63. KON OM, SIHRA BS, COMPTON CH, LEONARD TB, KAY AB, BARNES NC : Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 1998;352:1109-13.
64. MAUSER PJ, PITMAN AM, FERNANDEZ X et al. : Effects of an antibody to interleukin-5 in a monkey model of asthma. Am J Respir Crit Care Med 1995;152:467-72.
65. KUNO TT, STELTS DM, ZURCHER JA et al. : Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti IL-5 antibody. Am J Respir Cell Mol Biol 1995;13:360-5.
66. DEMOLY P, BOUSQUET J : Anti-IgE therapy for asthma. Am J Respir Crit Care Med 1997;155:1825-7.