-
1
-
-
0025039417
-
Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease
-
Männistö PT, Kaakkola S. Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol Toxicol 1990;66:317-23.
-
(1990)
Pharmacol Toxicol
, vol.66
, pp. 317-323
-
-
Männistö, P.T.1
Kaakkola, S.2
-
2
-
-
0025232430
-
Parkinson's disease
-
Marsden CD. Parkinson's disease. Lancet 1990;335:948-52.
-
(1990)
Lancet
, vol.335
, pp. 948-952
-
-
Marsden, C.D.1
-
3
-
-
0028471059
-
New and emerging strategies for improving levodopa treatment
-
Tolosa ES, Valldeoriola F, Marti MJ. New and emerging strategies for improving levodopa treatment. Neurology 1994:(suppl 6)44:S35-45.
-
(1994)
Neurology
, vol.44
, Issue.SUPPL. 6
-
-
Tolosa, E.S.1
Valldeoriola, F.2
Marti, M.J.3
-
4
-
-
0022443805
-
Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients
-
Nutt JG, Woodward WR. Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients. Neurology 1986;36:739-44.
-
(1986)
Neurology
, vol.36
, pp. 739-744
-
-
Nutt, J.G.1
Woodward, W.R.2
-
5
-
-
0016829492
-
Catechol-O-methyltransferase: Pharmacological aspects and physiological role
-
Guldberg HC, Marsden CA. Catechol-O-methyltransferase: pharmacological aspects and physiological role. Pharmacol Rev 1975;27:135-94.
-
(1975)
Pharmacol Rev
, vol.27
, pp. 135-194
-
-
Guldberg, H.C.1
Marsden, C.A.2
-
6
-
-
0023809040
-
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase
-
Männistö PT, Kaakkola S, Nissinen E, Linden I-B, Pohto P. Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase. Life Sci 1988;43:1465-71.
-
(1988)
Life Sci
, vol.43
, pp. 1465-1471
-
-
Männistö, P.T.1
Kaakkola, S.2
Nissinen, E.3
Linden, I.-B.4
Pohto, P.5
-
7
-
-
0025619387
-
Effect of the new selective COMT inhibitor CGP 28 014A on the formation of 3-O-methyldopa (3-OMD) in plasma of healthy subjects
-
Bieck PR, Nilsson E, Antonin KH. Effect of the new selective COMT inhibitor CGP 28 014A on the formation of 3-O-methyldopa (3-OMD) in plasma of healthy subjects. J Neural Transm Suppl 1990;32:387-91.
-
(1990)
J Neural Transm Suppl
, vol.32
, pp. 387-391
-
-
Bieck, P.R.1
Nilsson, E.2
Antonin, K.H.3
-
8
-
-
0013675681
-
Human pharmacokinetics of OR-462, a new catechol-O-methyltransferase inhibitor
-
Pentikäinen PJ, Vuorela A, Järvinen M, Wikberg T, Gordin A. Human pharmacokinetics of OR-462, a new catechol-O-methyltransferase inhibitor [Abstract]. Eur J Clin Pharmacol 1989; (suppl)36:A110.
-
(1989)
Eur J Clin Pharmacol
, vol.36
, Issue.SUPPL.
-
-
Pentikäinen, P.J.1
Vuorela, A.2
Järvinen, M.3
Wikberg, T.4
Gordin, A.5
-
9
-
-
0027514196
-
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
-
Keränen T, Gordin A, Harjola VP, et al. The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol 1993;16:145-56.
-
(1993)
Clin Neuropharmacol
, vol.16
, pp. 145-156
-
-
Keränen, T.1
Gordin, A.2
Harjola, V.P.3
-
10
-
-
0029044201
-
Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans
-
Dingemanse J, Jorga KM, Schmitt M, et al. Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans. Clin Pharmacol Ther 1995;57:508-17.
-
(1995)
Clin Pharmacol Ther
, vol.57
, pp. 508-517
-
-
Dingemanse, J.1
Jorga, K.M.2
Schmitt, M.3
-
11
-
-
0025657620
-
Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues
-
Zürcher G, Colzi A, Da Prada M. Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm Suppl 1990;32:375-80.
-
(1990)
J Neural Transm Suppl
, vol.32
, pp. 375-380
-
-
Zürcher, G.1
Colzi, A.2
Da Prada, M.3
-
12
-
-
0008757073
-
New therapeutic strategies in Parkinson's disease: Inhibition of MAO-B by Ro 19-6327 and of COMT by Ro 40-7592
-
Da Prada M, Zürcher G, Kettler R, Colzi A. New therapeutic strategies in Parkinson's disease: inhibition of MAO-B by Ro 19-6327 and of COMT by Ro 40-7592. Adv Behav Biol 1991;39:723-32.
-
(1991)
Adv Behav Biol
, vol.39
, pp. 723-732
-
-
Da Prada, M.1
Zürcher, G.2
Kettler, R.3
Colzi, A.4
-
13
-
-
0038036004
-
Determination of the catechol-O-methyltransferase inhibitor Ro 40-7592 in human plasma by high-performance liquid chromatography with coulometric detection
-
Timm U, Erdin R. Determination of the catechol-O-methyltransferase inhibitor Ro 40-7592 in human plasma by high-performance liquid chromatography with coulometric detection. J Chromatogr 1992;308:93-100.
-
(1992)
J Chromatogr
, vol.308
, pp. 93-100
-
-
Timm, U.1
Erdin, R.2
-
15
-
-
0029150356
-
Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa
-
Dingemanse J, Jorga K, Zürcher G, et al. Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. Br J Clin Pharmacol 1995;40:253-62.
-
(1995)
Br J Clin Pharmacol
, vol.40
, pp. 253-262
-
-
Dingemanse, J.1
Jorga, K.2
Zürcher, G.3
-
16
-
-
0025157730
-
Ro 40-7592: A novel, very potent, and orally active inhibitor of catechol-O-methyltransferase. A pharmacological study in rats
-
Zürcher G, Keller HH, Kettler R, et al. Ro 40-7592: a novel, very potent, and orally active inhibitor of catechol-O-methyltransferase. A pharmacological study in rats. Adv Neurol 1990;53:497-503.
-
(1990)
Adv Neurol
, vol.53
, pp. 497-503
-
-
Zürcher, G.1
Keller, H.H.2
Kettler, R.3
-
17
-
-
0023695286
-
Catechol-O-methyltransferase activity in human and rat small intestine
-
Nissinen E, Tuominen R, Perhoniemi V, Kaakkola S. Catechol-O-methyltransferase activity in human and rat small intestine. Life Sci 1988;42:2609-14.
-
(1988)
Life Sci
, vol.42
, pp. 2609-2614
-
-
Nissinen, E.1
Tuominen, R.2
Perhoniemi, V.3
Kaakkola, S.4
-
18
-
-
0028291661
-
Distribution of catechol-O-methyltransferase enzyme in rat tissues
-
Karhunen T, Tilgmann C, Ulmanen I, Julkunen I, Panula P. Distribution of catechol-O-methyltransferase enzyme in rat tissues. J Histochem Cytochem 1994;42:1079-90.
-
(1994)
J Histochem Cytochem
, vol.42
, pp. 1079-1090
-
-
Karhunen, T.1
Tilgmann, C.2
Ulmanen, I.3
Julkunen, I.4
Panula, P.5
-
20
-
-
0014638815
-
Dopamine (3-hydroxytyramine) metabolism in parkinsonism
-
Goodall M, Alton H. Dopamine (3-hydroxytyramine) metabolism in parkinsonism. J Clin Invest 1969;48:2300-8.
-
(1969)
J Clin Invest
, vol.48
, pp. 2300-2308
-
-
Goodall, M.1
Alton, H.2
-
21
-
-
0025046088
-
Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of I-dopa in healthy volunteers
-
Kaakkola S, Gordin A, Järvinen M, et al. Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of I-dopa in healthy volunteers. Clin Neuropharmacol 1990;13:436-47.
-
(1990)
Clin Neuropharmacol
, vol.13
, pp. 436-447
-
-
Kaakkola, S.1
Gordin, A.2
Järvinen, M.3
|