Enhanced renal outer medullary uptake of mercury associated with uninephrectomy: Implication of a luminal mechanism

Journal of Toxicology and Environmental Health

Volumn 50, Issue 2, 1997, Pages 173-194

  Zalups, Rudolfs K ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; MANNITOL; MERCURY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BLOOD; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; KIDNEY MEDULLA; KIDNEY TUBULE ABSORPTION; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS; UNINEPHRECTOMY;

ANIMALIA; GLOMERULUS;

EID: 0030938297     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/009841097160564     Document Type: Article

References (21)

1. Berndt, W. O., Baggett, J. M., Blacker, A., and Houser, M. 1985. Renal glutathione and mercury uptake by kidney. Fundam. Appl. Toxicol. 5:832-839.
2. Cafruny, E. J., Cho, K. C., and Gussin, R. Z. 1966. The pharmacology of mercurial diuretics. Ann. NY Acad. Sci. 139:362-374.
3. Clarkson, T. W., and Magos, L. 1970. Effect of 2,4-dinitrophenol and other metabolic inhibitors on the renal diposition and excretion of mercury. Biochem. Pharmacol. 19:3029-3037.
4. Foulkes, E. C. 1974. Excretion and retention of cadmium, zinc, and mercury by rabbit kidney. Am. J. Physiol. 227:1356-1360.
5. Malvin, R. L., and Wilde, W. S. 1973. Stop-flow technique. In Handbook of physiology, Section 8, Renal physiology, eds. J. Orloff and R. W. Berliner, vol. I, pp. 119-128. Washington, DC: American Physiological Society.
6. Roch-Ramel, F., Besseghir, K., and Murer, H. 1992. Renal excretion and tubular transport of organic anions and cations. In Handbook of physiology, Section 8, Renal physiology, ed. E. E. Windhager, vol. II, pp. 2189-2262. New York: Oxford University Press.
7. Scott, R. D., and Curthoys, N. P. 1987. Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism. Am. J. Physiol. 252:F877-F882.
8. Tanaka, T., Naganuma, A., and Imura, N. 1990. Role of y-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology 60:187-198.
9. Zalups, R. K. 1991a. Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride. J. Pharmacol. Methods 26:89-104.
10. Zalups, R. K. 1991b. Autometallographic localization of inorganic mercury in the kidneys of rats: Effect of unilateral nephrectomy and compensatory renal growth. Exp. Mol. Pathol. 54:1021.
11. Zalups, R. K. 1993. Influence of 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimer-captosuccinic acid (DMSA) on the renal disposition of mercury in normal and uninephrec-tomized rats exposed to inorganic mercury. J. Pharmacol. Exp. Ther. 267:791-800.
12. Zalups, R. K. 1995. Organic anion transport and action of y-glutamyltranspeptidase in kidney linked mechanistically to renal tubular uptake of Inorganic mercury. Toxicol. Appl. Pharmacol. 132:289-298.
13. Zalups, R. K., and Barfuss, D. W. 1990. Accumulation of inorganic mercury along the renal proximal tubule of the rabbit. Toxicol. Appl. Pharmacol. 106:245-253.
14. Zalups, R. K., and Barfuss, D. W. 1995. Pretreatment with p-aminohippurate inhibits the renal uptake and accumulation of injected inorganic mercury in the rat. Toxicology 103:23-35.
15. Zalups, R. K., Barfuss, D. W., and Kostyniak, P. J. 1992. Altered intrarenal accumulation of mercury in uninephrectomized rats treated with methylmercury chloride. Toxicol. Appl. Pharmacol. 115:174-182.
16. Zalups, R. K., and Cherian, M. G. 1992a. Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism. Toxicology 71:83-102.
17. Zalups, R. K., and Cherian, M. G. 1992b. Renal metallothionein metabolism after a reduction of renal mass. II. Effect of zinc pretreatment on the renal toxicity and intrarenal accumulation of inorganic mercury. Toxicology 71:103-117.
18. Zalups, R. K., and Lash, L. H. 1990. Advances in understanding the renal transport and toxicity of mercury. J. Pharmacol. Exp. Ther. 254:962-970.
19. Zalups, R. K., and Lash, L. H. 1994. Advances in understanding the renal transport and toxicity of mercury. J. Toxicol. Environ. Health 42:1-44.
20. Zalups, R. K., and Minor, K. H. 1995. Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury. J. Toxicol. Environ. Health 46:73-100.
21. Zalups, R. K., Klotzbach, J. M., and Diamond, G. L. 1987. Enhanced accumulation of inorganic mercury in renal outer medulla after unilateral nephrectomy. Toxicol. Appl. Pharmacol. 89:226-236.