Identification of SycN, YscX, and YscY, three new elements of the Yersinia Yop virulon

Journal of Bacteriology

Volumn 181, Issue 2, 1999, Pages 675-680

  Iriarte, Maite ^a   Cornelis, Guy R ^a,b  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ARTICLE; BACTERIUM IDENTIFICATION; EFFECTOR CELL; GENE LOCUS; GENETIC CODE; HOST CELL; IMMUNE RESPONSE; ISOELECTRIC POINT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN SECRETION; TARGET CELL; YERSINIA;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; YERSINIA;

EID: 0032929404     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.2.675-680.1999     Document Type: Article

References (45)

1. 2+ dependency, is related to ExsB of Pseudomonas aeruginosa. J. Bacteriol. 177:4230-4237.
2. Allaoui, A., R. Schulte, and G. R. Cornelis. 1995. Mutational analysis of the Yersinia enterocolitica virC operon: characterization of yscE, F, G, I, J, K, required for Yop secretion and yscH encoding YopR. Mol. Microbiol. 18: 343-355.
3. Allaoui, A., S. Woestyn, C. Sluiters, and G. R. Cornelis. 1994. YscU, a Yersinia enterocolitica inner membrane protein involved in Yop secretion. J. Bacteriol 176:4534-4542.
4. 2+-dependent functions in Yersinia peslis. J. Bacteriol. 172:4661-4671.
5. Bergman, T., K. Erickson, E. Galyov, C. Persson, and H. Wolf-Watz. 1994. The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium. J. Bacteriol. 176:2619-2626.
6. Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. EMBO J. 16: 2730-2744.
7. Boland, A., and G. R. Cornelis. 1998. Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection. Infect. Immun. 66:1878-1884.
8. Boland, A., M. P. Sory, M. Iriarte, C. Kerbourch, P. Wattiau, and G. R. Cornelis. 1996. Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus. EMBO J. 15:5191-5201.
9. Boyd, A. P., M.-P. Sory, M. Iriarte, and G. R. Cornelis. 1998. Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus. Mol. Microbiol. 27:425-436.
10. Cornelis, G., and E. P. Abraham. 1975. β-Lactamases from Yersinia enterocolitica. J. Gen. Microbiol. 87:273-284.
11. Cornelis, G. R., A. Boland, A. P. Boyd, C. Geuijen, M. Iriarte, C. Neyt, M.-P. Sory, and I. Stainier. 1998. Virulence plasmid of Yeninia, an antihost genome. Microbiol. Mol. Biol. Rev. 62:1315-1352.
12. Cornelis, G. R., M. Iriarte, and M. P. Sory. 1995. Environmental control of virulence functions and signal transduction in Yersinia enterocolitica, p. 95-110. In R. Rappuoli, V. Scarlato, and B. Arico (ed.), Signal transduction and bacterial virulence. R. G. Landes Company, Austin, Tex.
13. Cornelis, G. R., J. C. Vanooteghem, and C. Sluiters. 1987. Transcription of the yop regulon from Y. enterocolitica requires trans-acting pYV and chromosomal genes. Microb. Pathog. 2:367-379.
14. Cornelis, G. R., and H. Wolf-Watz. 1997. The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol. Microbiol. 23:861-867.
15. Eisenberg, D. 1984. Three-dimensional structure of membrane and surface proteins. Annu. Rev. Biochem. 53:595-623.
16. Forsberg, A., A. M. Viitanen, M. Skurnik, and H. Wolf-Watz. 1991. The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. Mol. Microbiol. 5:977-986.
17. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. A. Clayton, R. Lathigra, et al. 1997. Genomic sequence of a Lyme disease spirochete, Borrelia burgdorferi. Nature 390:580-586.
18. Galyov, E. E., S. Håkansson, A. Forsberg, and H. Wolf-Watz. 1993. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant. Nature 361:730-732.
19. Hueck, C. J. 1998. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62:379-433.
20. Iriarte, M., and G. R. Cornelis. 1998. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Mol. Microbiol. 29: 915-929.
21. Iriarte, M., and G. R. Cornelis. The 70-kb virulence plasmid of Yersinia. In J. B. Kaper and J. Hacker (ed.), Pathogenicity islands, virulence plasmids, and other mobile virulence elements, in press. American Society for Microbiology, Washington, D.C.
22. Iriarte, M., M. P. Sory, A. Boland, A. P. Boyd, S. D. Mills, I. Lambermont, and G. R. Cornelis. 1998. TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors. EMBO J. 17:1907-1918.
23. Jackson, M. W., J. B. Day, and G. V. Plano. 1998. YscB of Yersinia pestis functions as a specific chaperone for YopN. J. Bacteriol. 180:4912-4921.
24. Kaniga, K., I. Delor, and G. R. Cornelis. 1991. A wide-host-range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene 109:137-141.
25. Koster, M., W. Bitter, H. de Cock, A. Allaoui, G. K. Cornelis, and J. Tommassen. 1997. The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring-shaped multimeric complex. Mol. Microbiol. 26:789-798.
26. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
27. Michiels, T., J. C. Vanooteghem, C. L. Lambert de Rouvroit, B. China, A. Gustin, P. Boudry, and G. R. Cornelis. 1991. Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica. J. Bacteriol. 173:4994-5009.
28. Mills, S. D., A. Boland, M. P. Sory, P. Van der Smissen, C. Kerbourch, B. B. Finlay, and G. R. Cornelis. 1997. Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein. Proc. Natl. Acad. Sci. USA 94:12638-12643.
29. Monack, D. M., J. Mecsas, N. Ghori, and S. Falkow. 1997. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proc. Natl. Acad. Sci. USA 94:10385-10390.
30. Neyt, C., and G. R. Cornelis. Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD. Mol. Microbiol., in press.
31. Palmer, L. E., S. Hobbie, J. E. Galan, and J. B. Bliska. 1998. YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNFa production and downregulation of the MAP kinases p38 and JNK. Mol. Microbiol. 27:953-965.
32. 2+-response plasmid pCD1 of Yersinia pestis KIM5. Infect. Immun. 66:4611-4623.
33. Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. EMBO J. 16:2307-2318.
34. Plano, G. V., S. S. Barve, and S. C. Straley. 1991. LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. J. Bacteriol. 173:7293-7303.
35. Plano, G. V., and S. C. Straley. 1993. Multiple effects of lcrD mutations in Yersinia pestis. J. Bacteriol. 175:3536-3545.
36. Rosqvist, R., A. Forsberg, M. Rimpiläinen, T. Bergman, and H. Wolf-Watz. 1990. The cytotoxic protein YopE of Yersinia obstructs the primary host defence. Mol. Microbiol. 4:657-667.
37. Rosqvist, R., A. Forsberg, and H. Wolf-Watz. 1991. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect. Immun. 59:4562-4569.
38. Sarker, M. R., M.-P. Sory, A. P. Boyd, M. Iriarte, and G. R. Cornelis. 1998. LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells Infect. Immun. 66:2976-2979.
39. Skrzypek, E., and S. C. Straley. 1993. LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis. J. Bacteriol. 175:3520-3528.
40. Sory, M. P., A. Boland, I. Lambermont, and G. R. Cornelis. 1995. Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. Proc. Natl. Acad. Sci. USA 92:11998-12002.
41. Stainier, I., M. Iriarte, and G. R. Cornelis. 1997. YscM1 and YscM2, two Yersinia enterocolitica proteins causing down regulation of yop transcription. Mol. Microbiol. 26:833-843.
42. Viitanen, A. M., P. Toivanen, and M. Skurnik. 1990. The lcrE gene is part of an operon in the lcr region of Yersinia enterocolitica O:3. J. Bacteriol. 172: 3152-3162.
43. Wattiau, P., S. Woestyn, and G. R. Cornelis. 1996. Customized secretion chaperones in pathogenic bacteria. Mol. Microbiol. 20:255-262.
44. Woestyn, S., A. Allaoui, P. Wattiau, and G. R. Cornelis. 1994. YscN, the putative energizer of the Yersinia Yop secretion machinery. J. Bacteriol. 176: 1561-1569.
45. Yahr, T. L., L. M. Mende-Mueller, M. B. Friese, and D. W. Frank. 1997. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. J. Bacteriol. 179:7165-7168.