TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effecters

EMBO Journal

Volumn 17, Issue 7, 1998, Pages 1907-1918

  Iriarte, Maite ^a   Sory, Marie Paule ^a   Boland, Anne ^a   Boyd, Aoife P ^a   Mills, Scott D ^b   Lambermont, Isabelle ^a   Cornelis, Guy R ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bacteria host cell communication; Microbial pathogenesis; Signalling; Type III secretion; Yersinin

Indexed keywords

BACTERIAL PROTEIN; CALCIUM ION; OUTER MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; HOST PARASITE INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN TRANSPORT; YERSINIA;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; YERSINIA;

EID: 0032055051     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.7.1907     Document Type: Article

References (58)

1. Allaoui,A., Woestyn,S., Sluiters,C. and Cornelis,G.R. (1994) YscU, a Yersinia enterocolitica inner-membrane protein involved in Yop secretion. J. Bacteriol., 176, 4534-4542.
2. Allaoui,A., Schulte,R. and Cornelis,G.R. (1995) Mutational analysis of the Yersinia enterocoliticia virC operon: characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR. Mol. Microbiol., 18, 343-355.
3. Altschul,S.F., Gish,W., Miller, W., Myers,E.W. and Lipman,D.J. (1990) Basic local alignment search tool. J. Mol. Biol., 215, 403-410.
4. Bergman,T., Erickson,K., Galyov,E., Persson,C. and Wolf-Watz,H. (1994) The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium. J. Bacteriol., 176, 2619-2626.
5. Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. EMBO J., 16, 2730-2744.
6. Bodeus,M., Sory,M.-R. Fang,J.C., Janssens,M., Delferriere,N., Cornelis, G.R., Wauters,G. and Burtonboy,G. (1990) Production of rat hybridomas directed against Yersinia enterocolitica. In Bazin,H. (ed), Rat Hybridoma and Rat Monoclonal Antibodies. CRC Press, Boca Raton, FL, USA, pp. 335-338.
7. Boland,A. and Cornelis,G.R. (1998) Suppression of macrophage TNFγ release during Yersinia infection: role of YopP. Infect. Immun., in press.
8. Boland,A., Sory,M.P., Iriarte,M., Kerbourch,C., Wattiau,P. and Cornelis,G.R. (1996) Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y.enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus. EMBO J., 15, 5191-5201.
9. Boyd,A.P., Sory,M.-P., Iriarte,M. and Cornelis,G.R. (1998) Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus. Mol. Microbiol., 27, 425-436.
10. Cheng,L.W., Anderson,D.M. and Schneewind,O. (1997) Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica. Mol. Microbiol., 24, 757-765.
11. China,B., Michiels,T. and Cornelis,G.R. (1990) The pYV plasmid of Yersinia encodes a lipoprotein, YlpA, related to TraT. Mol. Microbiol., 4, 1585-1593.
12. Cornelis,G. and Abraham,E.P. (1975) β-Lactamases from Yersinia enterocolitica. J. Gen. Microbiol., 87, 273-284.
13. Cornelis,G. and Colson,C. (1975) Restriction of DNA in Yersinia enterocolitica detected by recipient ability for a derepressed R factor from Escherichia coli. J. Gen. Microbiol., 87, 285-291.
14. Cornelis,G.R. and Wolf-Watz,H. (1997) The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol. Microbiol., 23, 861-867.
15. Cornelis,G.R., Vanootegem,J.C. and Sluiters,C. (1987) Transcription of the yop regulon from Y.enterocolitica requires trans-acting pYV and chromosomal genes. Microb. Pathogen., 2, 367-379.
16. 2+ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis. J. Bacteriol., 176, 569-579.
17. Forsberg,A., Viitanen,A.M., Skurnik,M. and Wolf-Watz,H. (1991) The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. Mol. Microbiol., 5, 977-986.
18. Forsberg,A., Rosqvist,R. and Wolf-Watz,H. (1994) Regulation and polarized transfer of the Yersinia outer proteins (Yops) involved in antiphagocytosis. Trends Microbiol., 2, 14-19.
19. Frithz-Lindsten,E., Rosqvist,R., Johansson,L. and Forsberg,A. (1995) The chaperone-like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci. Mol. Microbiol., 16, 635-647.
20. Galyov,E.E., Håkansson,S., Forsberg,Å. and Wolf-Watz,H. (1993) A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant. Nature, 361, 730-732.
21. Gish,W. and States,D.J. (1993) Identification of protein coding regions by database similarity search. Nature Genet., 3, 266-272.
22. Guan,K.L. and Dixon,J.E. (1990) Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science, 249, 553-556.
23. Guan,K.L. and Dixon,J.E. (1991) Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glulathione S-transferase. Anal. Biochem., 192, 262-267.
24. Håkansson,S., Galyov,E.E., Rosqvist,R. and Wolf-Watz,H. (1996) The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol. Microbiol., 20, 593-603.
25. Hensel,M., Shea,J.E., Raupach,B., Monack,D., Falkow,S., Gleeson,C., Kubo,T. and Holden,D.W. (1997) Functional analysis of ssaJ and ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella pathogenicity island 2. Mol. Microbiol., 24, 155-167.
26. Kaniga,K., Delor,I. and Cornelis,G.R. (1991) A wide-host-range suicide vector for improving reverse genetics in Gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene, 109, 137-141.
27. Karger,A. and Mettenleiter,T.C. (1993) Glycoproteins gIII and gp50 play dominant roles in the biphasic attachment of pseuodorabies virus. Virology, 194, 654-664.
28. Kunkel,T.A., Roberts,J.D. and Zakour,R.A. (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol., 154, 367-382.
29. Lebrun,M., Mengaud,J., Ohayon,H., Nato,F. and Cossart,P. (1996) Internalin must be on the bacterial surface to mediate entry Listeria monocytogenes into epithelial cells. Mol. Microbiol., 21, 579-592.
30. Lupas,A., Van Dyke,M. and Stock,J. (1991) Predicting coiled coils from protein sequences. Science, 252, 1162-1164.
31. Michiels,T. and Cornelis,G.R. (1988) Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703. Microb. Pathogen., 5, 449-459.
32. Michiels,T., Wattiau,P., Brasseur,R., Ruysschaert,J.-M. and Cornelis,G.R. (1990) Secretion of Yop proteins by Yersiniae. Infect. Immun., 58, 2840-2849.
33. Michiels,T., Vanooteghem,J.C., Lambert de Rouvroit,C., China,B., Gustin,A., Boudry,P. and Cornelis,G.R. (1991) Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica. J. Bacteriol., 173, 4994-5009.
34. Miller,V.L. and Mekalanos,J.J. (1988) A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J. Bacteriol., 170, 2575-2583.
35. Mills,S.D., Boland,A., Sory,M.-P., Van Der Smissen,P., Kerbourch,C., Finlay,B.B. and Cornelis,G.R. (1997) YopP, a novel Yersinia effector protein, is delivered into macrophages to induce apoptosis. Proc. Natl Acad. Sci. USA, 94, 12638-12643.
36. Monack,D.M., Mecsas,J., Ghori,N. and Falkow,S. (1997) Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proc. Natl Acad. Sci. USA, 94, 10385-10390.
37. Pearson,W.R. and Lipman,D.J. (1988) Improved tools for biological sequence comparison. Proc. Natl Acad. Sci. U.S.A, 85, 2444-2448.
38. Persson,C., Nordfelth,R., Holmström,A., Håkansson,S., Rosqvist,R. and Wolf-Watz,H. (1995) Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell. Mol. Microbiol., 18, 135-150.
39. Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. EMBO J., 16, 2307-2318.
40. Plano,G.V., Barve,S.S. and Straley,S.C. (1991) LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. J. Bacteriol., 173, 7293-7303.
41. Rosenshine,I., Ruschkowski,S., Stein,M., Reinscheid,D.J., Mills,S.D. and Finlay,B.B. (1996) A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation. EMBO J., 15, 2613-2624.
42. Rosqvist,R., Forsberg,A. and Wolf-Watz,H. (1991) Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect. Immun., 59, 4562-4569.
43. Rosqvist,R., Magnusson,K.E. and Wolf-Watz,H. (1994) Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J., 13, 964-972.
44. Sarker,M.R., Neyt,C., Stainier,I. and Cornelis,G.R. (1998a) The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD. J. Bacteriol., 180, in press.
45. Sarker,M.R., Sory,M.-P., Boyd,A.P., Iriarte,M. and Cornelis,G.R. (1998b) LcrG controls internalization of Yersinia Yop effector proteins into eukaryotic cells. Infect. Immun., in press.
46. Skrzypek,E. and Straley,S. (1993) LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis. J. Bacteriol., 175, 3520-3528.
47. Smith,D.B. and Johnson,K.S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione 5-transferase. Gene, 67, 31-40.
48. Sory,M.-P. and Cornelis,G.R. (1994) Translocation of a hybrid YopEadenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol. Microbiol., 14, 583-594.
49. Sory,M.-P., Kaniga,K., Goldenberg,S. and Cornelis,G.R. (1992) Expression of the eukaryotic Trypanosoma cruzi CRA gene in Yersinia enterocolitica and induction of an immune response against CRA in mice. Infect. Immun., 60, 3830-3836.
50. Sory,M.-P., Boland,A., Lambermont,I. and Cornelis,G.R. (1995) Identification of YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. Proc. Natl Acad. Sci. USA, 92, 11998-12002.
51. Viitanen,A.M., Toivanen,P. and Skurnik,M. (1990) The lcrE gene is part of an operon in the lcr region of Yersinia enterocolitica O:3. J. Bacteriol., 172, 3152-3162.
52. Wattiau,P. and Cornelis,G.R. (1993) SycE, a chaperone-like protein of Yersinia enterocolitica involved in the secretion of YopE. Mol. Microbiol., 8, 123-131.
53. Wattiau,P., Bernier,B., Deslee,P., Michiels,T. and Cornelis,G.R. (1994) Individual chaperones required for Yop secretion by Yersinia. Proc. Natl Acad. Sci. USA, 91, 10493-10497.
54. Wattiau,P., Woestyn,S. and Cornelis,G.R. (1996) Customized secretion chaperones in pathogenic bacteria. Mol. Microbiol., 20, 255-262.
55. Woestyn,S., Allaoui,A., Wattiau,P. and Cornelis,G.R. (1994) YscN, the putative energizer of the Yersinia Yop secretion machinery. J. Bacteriol., 176, 1561-1569.
56. Woestyn,S., Sory,M.P., Boland,A., Lequenne.O. and Coraelis,G.R. (1996) The cytosolic SycE and SycH chaperones of Yersinia protect the region of YopE and YopH involved in translocation accross eukaryotic cell membranes. Mol. Microbiol., 20, 1261-1271.
57. Yahr,T.L., Mende-Mueller,L.M., Friese,M.B. and Frank,D.W. (1997) Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. J. Bacteriol., 179, 7165-7168.
58. Zsak,L., Sugg,N., Ben-Porat,T., Robbins,A.K., Whealy,M.E. and Enquist,L.W. (1991) The gill glycoprotein of pseudorabies virus is involved in two distinct steps of virus attachment. J. Virol., 65, 4317-4324.