Effect of aerosolized administration of KF19514, a phosphodiesterase 4 inhibitor, on bronchial hyperresponsiveness and airway inflammation induced by antigen inhalation in guinea-pigs

Clinical and Experimental Allergy

Volumn 30, Issue 5, 2000, Pages 713-718

  Myou, S ^a   Fujimura, M ^a   Kurashima, K ^a   Tachibana, H ^a   Hirose, T ^a   Nakao, S ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway inflammation; Antigen challenge; Bronchial hyperresponsiveness; Eosinophils; Guinea pigs; KF19514; Methacholine; Neutrophils; Olprinone; Phosphodiesterase inhibitor

Indexed keywords

5 PHENYL 3 (3 PYRIDYL)METHYL 3H IMIDAZO[4,5 C][1,8]NAPHTHYRIDIN 4(5H)ONE; ANTIGEN; IMIDAZO[4,5 C]PYRIDINE DERIVATIVE; KF 19514; LOPRINONE; METHACHOLINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; EOSINOPHIL; GUINEA PIG; INFLAMMATION; LUNG LAVAGE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTIGENS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHODILATOR AGENTS; GUINEA PIGS; IMIDAZOLES; MALE; METHACHOLINE CHLORIDE; NAPHTHYRIDINES; OVALBUMIN; PHOSPHODIESTERASE INHIBITORS; PYRIDONES;

EID: 0034084934     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00782.x     Document Type: Article

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